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Hydrocortisone

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
(7S,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

Hydrocortisone is in a solid state at room temperature.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
531.50
Boiling point (Kelvin)
804.65
General information
Molecular weight
362.47g/mol
Molar mass
362.4660g/mol
Density
1.3000g/cm3
Appearence

Hydrocortisone appears as a white to practically white crystalline powder. It is odorless and has a bitter taste. As a steroid hormone, it is generally water-insoluble but soluble in alcohol and most organic solvents.

Comment on solubility

Solubility of (7S,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of this complex organic compound can be influenced by various factors such as its molecular structure, polarity, and the solvent used. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of hydroxyl groups typically increases a compound's polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic Characteristics: Given the extensive hydrocarbon framework and multiple methyl groups, this compound may exhibit significant hydrophobic behavior, leading to higher solubility in non-polar solvents such as hexane or chloroform.
  • Temperature Dependency: Solubility often varies with temperature. Increased temperature generally enhances solubility for most compounds.
  • Diverse Solvent Compatibility: When exploring solubility, it is crucial to test various solvents, including alcohols and oils, to observe how this compound behaves in different environments.

In quotations, some researchers have noted that "the intricate balance between hydrophobic and hydrophilic interactions plays a pivotal role in determining the solubility of steroid-like compounds." Thus, experimental data would provide essential insights into the solubility of this compound.

Overall, while the exact solubility profile may require empirical measurement, understanding the molecular interactions at play is key to predicting its behavior in various solvent systems.

Interesting facts

Interesting Facts about 17-Hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This complex and fascinating compound is a member of the steroid family and is notable for its structural intricacies and biological significance. Here are some engaging details:

  • Steroid Backbone: The compound features a steroid backbone, crucial for numerous biological activities. Steroids often influence hormonal functions, cell signaling, and various metabolic processes.
  • Biological Relevance: Compounds like this one play vital roles in the human body. They can function as precursors to hormones and other biologically active molecules.
  • Chirality: This molecule contains multiple chiral centers, leading to different stereoisomers. The specific arrangement of atoms is critical for the compound's activity, emphasizing the importance of stereochemistry in drug design.
  • Variability in Applications: Due to its structural characteristics, this compound can be investigated for various applications, including therapeutic uses in medicine or as potential supplements in sports science.
  • Research Potential: The ongoing study of steroids can shed light on treatments for hormone-related disorders and the development of anabolic agents. Researchers are continually exploring mechanisms and effects, making this a lively field of investigation.

In summary, (7S,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one is not just a chemical entity but a significant player in the biological landscape. Its effects and applications continue to be a subject of extensive research, illustrating the balance between chemistry and biology

Synonyms
CALUSTERONE
Methosarb
17021-26-0
Calusterona
Calusteronum
7-beta,17-Dimethyltestosterone
7beta,17alpha-Dimethyltestosterone
7beta,17-Dimethyltestosterone
NSC-88536
7-beta,17-alpha-Dimethyl testosterone
17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one
U-22,550
17beta-Hydroxy-7beta,17-dimethylandrost-4-en-3-one
17beta-Hydroxy-7beta,17alpha-dimethylandrost-4-ene-3-one
U-22550
0678G6Q58A
Androst-4-en-3-one, 17beta-hydroxy-7beta,17-dimethyl-
DTXSID0022723
Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7beta,17beta)-
NSC88536
7-beta-17-alpha-dimethyltestosterone
(1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-5-one
(1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
DTXCID402723
7beta, 17alpha-Dimethyltestosterone
7 beta,17 alpha-dimethyltestosterone
7 Beta, 17 Alpha-dimethyltestosterone
17-Beta-hydroxy-7-beta, 17-dimethylandrost-4-ene-3-one
17 Beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one
Androst-4-en-3-one, 7beta, 17alpha-dimethyl-17beta-hydroxy-
Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7beta, 17beta)-
Dimethyltestosterone
(7S,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
U 22550
Calusteron
17-beta-hydroxy-7-beta-17-dimethyl androst-4-en-3-one
7.beta.,17.alpha.-Dimethyltestosterone
CLS
Calusteronum [INN-Latin]
Calusterona [INN-Spanish]
Calusterone [USAN:INN]
Calusterone (1.0mg/ml in Acetonitrile)
HSDB 3210
7.beta.,17-Dimethyltestosterone
BRN 3212336
Androst-4-en-3-one,17-dimethyl-
UNII-0678G6Q58A
17-Hydroxy-7,17-dimethylandrost-4-en-3-one
Androst-4-en-3-one, 17-beta-hydroxy-7-beta,17-dimethyl-
Androst-4-en-3-one, 7beta,17alpha-dimethyl-17beta-hydroxy-
CALUSTERONE [MI]
7beta-Dimethyltestosterone
CALUSTERONE [INN]
Calusterone (USAN/INN)
CALUSTERONE [HSDB]
CALUSTERONE [USAN]
SCHEMBL4509
17.beta.-Hydroxy-7.beta.,17-dimethylandrost-4-en-3-one
CALUSTERONE [MART.]
17beta-Dimethyl testosterone
CALUSTERONE [WHO-DD]
4-08-00-01029 (Beilstein Handbook Reference)
17.beta.-Hydroxy-7.beta.,17.alpha.-dimethylandrost-4-ene-3-one
CHEMBL455706
7beta,17beta-Dimethyltestosterone
CHEBI:135356
7-.beta.-17-dimethyltestosterone
Androst-4-en-3-one, 7-beta,17-alpha-dimethyl-17-beta-hydroxy-
Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7-beta,17-beta)-
DB01564
7.beta.,17.alpha.-Dimethyl testosterone
7-.beta.-17-.alpha.-dimethyltestosterone
NS00067932
D03338
17b-Hydroxy-7b,17-dimethylandrost-4-en-3-one
17b-hydroxy-7b,17-dimethyl-Androst-4-en-3-one
17-dimethyl-17beta-hydroxy-7beta-Androst-4-en-3-one
17beta-Hydroxy-7beta-17-dimethylandrost-4-en-3-one
4-Androsten-7beta,17alpha-dimethyl-17beta-ol-3-one
Q14201166
WLN: L E5 B666 OV MUTJ A1 E1 FQ F1 K1
7beta,17alpha-Dimethyl-17betahydroxyandrost-4-en-3-one
(7b,17b)-17-hydroxy-7,17-dimethyl-Androst-4-en-3-one
17beta-Hydroxy-7beta-17alpha-dimethylandrost-4-ene-3-one
Androst-4-en-3-one,17-dimethyl-, (7.beta.,17.beta.)-
Androst-4-en-3-one,17.alpha.-dimethyl-17.beta.-hydroxy-
17-.beta.-hydroxy-7-.beta.-17-dimethyl androst-4-en-3-one
(7beta,8xi,17beta)-17-hydroxy-7,17-dimethylandrost-4-en-3-one
7.BETA.,17.ALPHA.-DIMETHYL-17.BETA.-HYDROXYANDROST-4-EN-3-ONE