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Clozapine

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Identification
Molecular formula
C7H5ClN4
CAS number
5786-21-0
IUPAC name
8-[2-[(2-chlorophenyl)methylene]hydrazino]-1,3,7-trimethyl-purine-2,6-dione
State
State

At room temperature, Clozapine is in a solid state. It is usually handled as a powder for pharmacological applications.

Melting point (Celsius)
100.50
Melting point (Kelvin)
373.65
Boiling point (Celsius)
354.50
Boiling point (Kelvin)
627.65
General information
Molecular weight
270.74g/mol
Molar mass
270.7430g/mol
Density
1.2719g/cm3
Appearence

The compound typically appears as a yellow, crystalline powder. It is known for its light-sensitive nature, which is common among compounds with multiple aromatic rings.

Comment on solubility

Solubility of 8-[2-[(2-chlorophenyl)methylene]hydrazino]-1,3,7-trimethyl-purine-2,6-dione

The solubility of 8-[2-[(2-chlorophenyl)methylene]hydrazino]-1,3,7-trimethyl-purine-2,6-dione is an intriguing topic, as it incorporates various structural features that can influence its interaction with solvents.

Factors Influencing Solubility

Several factors can impact the solubility of this compound:

  • Polarity: The presence of polar functional groups, such as hydrazine moieties, suggests a potential for increased solubility in polar solvents.
  • Hydrophobic Regions: The trimethyl group and the chlorophenyl component may hinder solubility in highly polar environments, leading to better solubility in organic solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding, particularly with hydrophilic solvents, could also enhance solubility.

Solvent Compatibility

This compound is likely to demonstrate variable solubility depending on the solvent used:

  • Water: Limited solubility due to hydrophobic characteristics.
  • Organic Solvents: Increased solubility in organic solvents such as methanol or dimethyl sulfoxide (DMSO).
  • Aqueous Solutions: May require the use of surfactants or co-solvents to improve solubility in water.

Understanding the solubility of this compound not only helps in practical applications but also aids in predicting its behavior in biological systems, drug formulation, and chemical reactivity. Thus, when considering this intriguing molecule, it is important to conduct specific solubility tests to ascertain its behavior in various environments.

Interesting facts

Interesting Facts about 8-[2-[(2-chlorophenyl)methylene]hydrazino]-1,3,7-trimethyl-purine-2,6-dione

This compound is a fascinating member of the purine family, exhibiting diverse biological activities that make it a subject of interest in pharmaceutical research. Known for its possible applications in medicinal chemistry, it showcases potential as an antitumor agent. Here are some intriguing aspects of this compound:

  • Structural Innovation: The unique combination of a hydrazino group and a chlorophenyl moiety attached to the purine ring demonstrates innovative structural characteristics that may enhance its biological properties.
  • Biological Relevance: Studies suggest that derivatives of this compound might interact with key biological targets, including those involved in regulatory pathways of cell proliferation and survival.
  • Potential Therapeutic Uses: The molecular architecture of this compound hints at possibilities in the treatment of various cancers, with ongoing research aimed at evaluating its efficacy and safety in clinical contexts.
  • Mechanistic Insights: Understanding the pharmacodynamics and pharmacokinetics of compounds like this one can provide valuable insights into the design of new therapies that can selectively target malignant cells.
  • Continued Research: The ongoing investigation into the interactions of this compound with biomolecules is critical in unveiling its full potential and expanding the scope of purine derivatives in drug discovery.

As we delve deeper into the realm of synthetic organic chemistry, compounds like 8-[2-[(2-chlorophenyl)methylene]hydrazino]-1,3,7-trimethyl-purine-2,6-dione illustrate the incredible complexity and potential utility of modified purines in therapeutic applications. With its promising structure and mechanistic pathways, it stands at the frontier of modern pharmacological research.