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Rapamycin

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Identification
Molecular formula
C51H79NO13
CAS number
53123-88-9
IUPAC name
8-[4-hydroxy-6-methyl-5-(methylamino)tetrahydropyran-2-yl]oxy-7,11,13,19-tetramethyl-1-azacycloicosa-3,5,10,13,15-pentaen-2-one
State
State

At room temperature, rapamycin is typically found as a solid. It is stable under normal temperatures and pressures, although it should be stored in a cool and dry place to prevent degradation.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
914.17g/mol
Molar mass
914.1720g/mol
Density
0.9587g/cm3
Appearence

Rapamycin appears as a white to off-white crystalline powder. It is known for its poor solubility in water. The crystals may vary in size depending on the method of synthesis and purification.

Comment on solubility

Solubility of 8-[4-Hydroxy-6-methyl-5-(methylamino)tetrahydropyran-2-yl]oxy-7,11,13,19-tetramethyl-1-azacycloicosa-3,5,10,13,15-pentaen-2-one

The compound 8-[4-hydroxy-6-methyl-5-(methylamino)tetrahydropyran-2-yl]oxy-7,11,13,19-tetramethyl-1-azacycloicosa-3,5,10,13,15-pentaen-2-one (C51H79NO13) exhibits interesting solubility characteristics that stem from its complex molecular structure.

Regarding its solubility:

  • Polar and Nonpolar Solvents: Given its extensive hydrocarbon chain with multiple functional groups, the solubility of this compound may vary significantly between polar and nonpolar solvents.
  • Hydrogen Bonding: The presence of hydroxyl groups suggests that it may form hydrogen bonds with water, potentially leading to moderate solubility in polar solvents.
  • Effects of Molecular Weight: With a substantial molecular weight (overall large number of atoms), its solubility may be limited compared to smaller organic compounds.
  • Concentration-Dependent Behavior: The solubility could alter at different concentrations, indicating potential applications in pharmaceutical formulations.

In summary, while this compound may exhibit some degree of solubility in polar solvents due to its functional groups, its overall solubility profile will be influenced by factors such as molecular weight and solvent type. The complex nature of its structure necessitates empirical testing for precise solubility data.

Interesting facts

Interesting Facts about 8-[4-hydroxy-6-methyl-5-(methylamino)tetrahydropyran-2-yl]oxy-7,11,13,19-tetramethyl-1-azacycloicosa-3,5,10,13,15-pentaen-2-one

This compound is a fascinating example of complex organic chemistry, characterized by its intricate structure and unique functional groups. Scientists have become increasingly interested in it due to its potential biological activity, which opens the door for numerous applications in pharmaceuticals and medicine.

Key Features

  • Diversity of Functional Groups: The compound contains a variety of functional groups, including hydroxyls, methylamino groups, and a tetrahydropyran unit, making it a chameleon of sorts, capable of engaging in a range of chemical reactions.
  • Structural Complexity: The azacyclo compound features a large cyclic structure (icosa-), which adds to its intriguing properties and behavior in chemical reactions.
  • Potential Therapeutic Uses: Due to its intricate design and novel functional groups, this compound may exhibit important biological activities, including anti-cancer properties and effects on neurotransmitter pathways, although extensive research is required.

Research Opportunities

Researchers are excited about exploring this compound for various reasons:

  • Medicinal Chemistry: The potential to develop new drugs targeting specific health issues.
  • Organic Synthesis: It serves as an excellent platform for synthetic chemists to design new derivatives and study their properties.
  • Biological Studies: Investigating the interactions of this compound within biological systems could unveil new mechanisms of action.

In the words of a leading chemist, "Understanding the intricacies of such compounds may lead us to breakthroughs that can change the landscape of medicine." As research continues, this compound stands as a testament to the beauty and complexity found within organic chemistry.

Synonyms
NSC641691
Neuro_000316
7,11,13,19-Tetramethyl-2-oxoazacycloicosa-3,5,10,13,15-pentaen-8-yl 2,4,6-trideoxy-4-(methylamino)hexopyranoside
NCI60_014096