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Olmutinib

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Identification
Molecular formula
C29H24N4O3
CAS number
1353550-13-6
IUPAC name
8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one
State
State

Olmutinib is typically in a solid state at room temperature. The solid form is suited for pharmaceutical formulation and storage purposes.

Melting point (Celsius)
238.50
Melting point (Kelvin)
511.65
Boiling point (Celsius)
683.30
Boiling point (Kelvin)
956.45
General information
Molecular weight
486.54g/mol
Molar mass
486.5570g/mol
Density
1.4000g/cm3
Appearence

Olmutinib appears as a fine, crystalline powder that is off-white to pale yellow in color. It may exhibit different shades, depending on its form and purity level.

Comment on solubility

Solubility of 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one (C29H24N4O3)

The solubility of 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one can be quite nuanced, given its complex molecular structure. This compound, with its rich aromatic and hydrophilic components, presents several interesting solubility characteristics:

  • Polar and Nonpolar Interactions: Due to the presence of hydroxyl (-OH) groups, this compound is likely to exhibit a degree of solubility in polar solvents such as water, while its extensive aromatic system can also allow for solubility in organic solvents such as ethanol or chloroform.
  • Temperature and Solvent Dependency: Solubility may vary significantly with temperature. Generally, higher temperatures increase solubility for solid compounds. It is essential to test in various solvents to determine the optimal conditions.
  • pH Influence: The solubility is also expected to be affected by the pH of the solution due to the ionizable hydroxyl groups. Under acidic conditions, the solubility might be enhanced.
  • Aggregation Behavior: There may be self-aggregation in solution due to stacking interactions among the aromatic rings, potentially leading to decreased solubility under certain conditions.

In conclusion, while assessing the solubility of this compound, it is crucial to consider multiple factors including solvent polarity, temperature, pH, and molecular interaction dynamics. The complexity of such compounds often leads to intriguing behavior in solution.

Interesting facts

Exploring 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one

This fascinating compound is an exemplar of the intricate world of organic chemistry, particularly within the realm of heterocyclic compounds. Here are some intriguing aspects about this compound:

  • Structural Complexity: The structure is characterized by a fused imidazo[1,2-a]pyrazine ring, showcasing the fascinating versatility in heterocyclic chemistry, aiming to deliver unique electronic and optical properties.
  • Potential Biological Activity: Many compounds featuring similar structural motifs are investigated for their medicinal properties, particularly targeting cancer and inflammatory diseases. This compound could be part of ongoing studies looking for new therapeutics.
  • Hydroxyl Functional Groups: The presence of multiple hydroxyphenyl groups suggests potential for strong hydrogen bonding and interactions with biological targets, which can enhance its bioactivity.
  • Synthetic Routes: The synthesis of imidazo[1,2-a]pyrazines often requires innovative synthetic methods. Understanding the synthesis of this compound could also contribute to advancements in medicinal chemistry.

As we delve deeper into the universe of organic compounds, the complexity and diversity often drive the synthesis towards exploring new applications and understanding various biological mechanisms. The journey of 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one may lead to the discovery of groundbreaking innovations in pharmacology.

In conclusion, compounds like this not only challenge our understanding of chemical interactions but also fuel scientific curiosity, pushing the boundaries of what is possible in the field of medicinal chemistry and beyond.