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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole
State
State

At room temperature, Clozapine is in a solid state, specifically in the form of crystalline powder. This is common for many alkaloids and pharmaceutical compounds, lending itself well to formulation in tablets or capsules.

Melting point (Celsius)
183.40
Melting point (Kelvin)
456.55
Boiling point (Celsius)
397.30
Boiling point (Kelvin)
670.45
General information
Molecular weight
326.82g/mol
Molar mass
326.8170g/mol
Density
1.2790g/cm3
Appearence

Clozapine is typically a pale yellow crystalline solid. This appearance can vary slightly based on the purity and the form in which it is isolated (e.g., anhydrous, hydrated).

Comment on solubility

Solubility of 8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole

The solubility of 8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole in various solvents is an intriguing aspect of its chemical behavior. Understanding its solubility can provide insights into its potential applications and interactions.

  • Polar solvents: This compound may exhibit limited solubility in polar solvents, such as water, due to its bulky hydrophobic structure and the presence of chlorine atoms affecting its ability to interact favorably with water molecules.
  • Non-polar solvents: Conversely, it is likely to be more soluble in non-polar solvents like hexane or chloroform. This enhanced solubility can be attributed to the hydrophobic interactions that dominate in these environments.

Furthermore, the solubility of compounds in solution can be influenced by factors such as:

  1. Temperature: Increasing temperature often enhances solubility, particularly in solid compounds.
  2. pH: The ionization state of the compound may vary with pH, thereby affecting its solubility in aqueous solutions.
  3. Presence of co-solvents: Utilizing a mixture of solvents can sometimes improve solubility, making it a common practice in laboratory settings.

In conclusion, understanding the solubility characteristics of 8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole is essential for any application.

Interesting facts

Exploring 8-Chloro-2-Methyl-1,3,4,5-Tetrahydropyrido[4,3-b]indole

8-Chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole is a fascinating compound that belongs to a class of chemicals known as indoles, which are well-known for their roles in various biological activities. Here are some key points to understand this intriguing compound:

  • Chemical Structure: The unique structure of this compound features a polycyclic framework that consists of both pyridine and indole components. This combination is significant as it can influence the compound's biological properties and reactivity.
  • Biological Importance: Compounds related to indoles and pyridines often exhibit a variety of biological activities. They can act as antioxidants, antimicrobial agents, and even antidepressants in some cases, making this specific compound a subject of interest in medicinal chemistry.
  • Chlorine Substitution: The presence of a chlorine atom in the structure can enhance the compound’s lipophilicity and biological activity. Chlorinated compounds often serve as crucial intermediates in the synthesis of pharmaceuticals.
  • Synthetic Versatility: The synthetic pathways leading to the formation of such indoles can involve various advanced organic reactions, allowing for the potential development of derivatives with enhanced properties.
  • Research Applications: Researchers are continually investigating the pharmacological mechanisms of compounds like 8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole. They may hold the key to understanding new therapeutic agents.

In conclusion, the study of 8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole encompasses not only its intriguing structural features but also its potential implications in the field of medicinal chemistry. As research continues, this compound may lead to exciting developments in drug discovery and therapeutic applications.

Synonyms
17223-45-9
8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole
8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indole
871-033-3
8-Chloro-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
8-chloro-2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole
8-Chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole
MFCD03005789
1H-Pyrido[4,3-b]indole, 8-chloro-2,3,4,5-tetrahydro-2-methyl-
PY3SDQ9L6L
6-Chloro-3-methyl-1,2,3,4-tetrahydrocarboline
SCHEMBL167328
CHEMBL160173
HMS1621A02
SAA22345
STL513494
AKOS004119530
SS-3475
NCGC00167414-01
CS-0062521
D73209
EN300-224032
SR-01000150201
SR-01000150201-1
Z1130219749
6-Chloro-3-methyl-1,2,3,4-tetrahydro-.gamma.-carboline
2,3,4,5-Tetrahydro-2-methyl-8-chloro-1H-pyrido[4,3-b]indole
8-Chloro 2-methyl-2,3,4,5-tetrahydro-1H-pyrido (4,3-b) indole
8-Chloro-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole #