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clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
8-chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
State
State

At room temperature, clozapine is in a solid state. It is typically encountered as a dry powder, especially in pharmaceutical formulations where it is pressed into tablet form for clinical use.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
574.15
Boiling point (Kelvin)
847.30
General information
Molecular weight
326.83g/mol
Molar mass
326.8250g/mol
Density
1.4150g/cm3
Appearence

Clozapine is typically found as a pale yellow, crystalline powder. It is sensitive to light and may degrade upon exposure, so it is often stored in opaque containers to preserve its integrity. The compound has a slight odor and is known for its use in the medical field, presenting as a bulk powder in pharmaceutical applications.

Comment on solubility

Solubility of 8-chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole

The solubility of 8-chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole is an intriguing subject for study due to its complex structure. While specific solubility data may not always be readily available, we can consider the following factors that influence its solubility:

  • Polarity: The presence of the chlorinated and pyridine moieties introduces polar character to the molecule, potentially enhancing solubility in polar solvents.
  • Hydrophobic Interactions: The indole structure and alkyl substituents may contribute to hydrophobic interactions which could limit solubility in water.
  • Functional Groups: The presence of the nitrogen atoms in the pyridine and indole rings can facilitate hydrogen bonding, affecting solubility in different solvents.

Based on the above points, it is plausible to conclude that:

  1. The compound may exhibit good solubility in organic solvents like dimethyl sulfoxide (DMSO) or ethyl acetate.
  2. However, it is likely to be less soluble in polar protic solvents such as water.

Thus, understanding the solubility profile of this compound can be essential for its application in pharmaceutical formulations and chemical reactions. As always, experimental verification is crucial to confirm these theoretical insights.

Interesting facts

Interesting Facts about 8-Chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole

8-Chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole is a fascinating compound renowned for its unique structure and potential applications in various fields. Here are some interesting insights about this compound:

  • Pharmacological Potential: This compound shows promise in medicinal chemistry due to its structural resemblance to biologically active molecules. Its derivatives may exhibit various pharmacological activities, making it of interest for drug development.
  • Structural Complexity: The intricate arrangement of its pyrido rings and halogen substitutions exemplifies the diversity of organic structures. Such complexity is often associated with the modulation of biological activity, leading to enhanced potency in therapeutic applications.
  • Mechanism Exploration: Researchers are keen on uncovering the mechanism of action of this compound. Due to its multifaceted structure, it might interact with multiple biological targets, potentially leading to novel therapeutic strategies.
  • Structure-Activity Relationship (SAR): The specific substitution patterns of this compound can significantly affect its biological activity. Understanding the SAR can aid chemists in designing more effective analogs tailored for specific applications.
  • Interdisciplinary Research: This compound is an example of how chemistry intersects with pharmacology and biochemistry. Collaborative efforts in these fields can lead to groundbreaking discoveries in the treatment of various conditions.

In conclusion, the study of 8-chloro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole not only highlights the beauty of chemical diversity but also underscores the potential for innovation in drug discovery. As researchers continue to explore its properties, we may find exciting new applications that can transform our understanding of treatment options.

Synonyms
Dorastine
21228-13-7
Dorastine [INN]
NSC-306726
DTXSID9057682
3087NKH40A
UNII-3087NKH40A
DTXCID0031471
NSC 306726
1H-PYRIDO(4,3-B)INDOLE, 8-CHLORO-2,3,4,5-TETRAHYDRO-2-METHYL-5-(2-(6-METHYL-3-PYRIDINYL)ETHYL-
8-CHLORO-2,3,4,5-TETRAHYDRO-2-METHYL-5-(2-(6-METHYL-3-PYRIDIYL)ETHYL)-1H-PYRIDO(4,3-B)INDOLE
RefChem:135661
8-chloro-2-methyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
Dorastina
SCHEMBL3116611
CHEMBL2110839
SCHEMBL29387736
WCTGYFWVYBPRGF-UHFFFAOYSA-N
Tox21_113845
NSC306726
NCGC00253726-01
CAS-21228-13-7
NS00126246
Q27255929
1H-Pyrido[4, 8-chloro-2,3,4,5-tetrahydro-2-methyl-5-[2-(6-methyl-3-pyridyl)ethyl]-
8-chloro-2,3,4,5-tetrahydro-2-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indole