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Lofexidine

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Identification
Molecular formula
C11H12ClN3O
CAS number
57808-66-9
IUPAC name
8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
State
State

At room temperature, Lofexidine is typically in a solid state.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
563.15
Boiling point (Kelvin)
836.15
General information
Molecular weight
293.80g/mol
Molar mass
293.8000g/mol
Density
1.3120g/cm3
Appearence

Lofexidine typically appears as a white to off-white crystalline powder. It is important to note that appearance can vary depending on the specific conditions and formulation of the compound.

Comment on solubility

Solubility of 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol

The compound 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol, with the chemical formula C11H12ClN3O, exhibits characteristics that can influence its solubility in various solvents. Here are some key aspects to consider:

  • Polarity: The presence of a hydroxyl group (-OH) in the structure significantly increases *hydrophilicity*, suggesting potential solubility in polar solvents such as water.
  • Chlorine Atom: The chlorine atom may also influence solubility, often enhancing interactions with water molecules while still retaining some extent of lipophilicity.
  • Amine Functional Group: The amine functional group (indicated by the nitrogen atoms) can participate in hydrogen bonding, which further promotes solubility in polar solvents.
  • Solvent Effects: This compound might display variable solubility depending on the solvent used. Common solvents such as ethanol or acetone may aid in dissolution due to similar polar characteristics.

Overall, while specific solubility data may not be readily available, the outlined factors suggest that 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol could be soluble to a certain extent in polar solvents, making it an interesting compound for further solubility investigations.

Interesting facts

Interesting Facts about 8-Chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol

The compound 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is a fascinating example of a complex organic molecule that belongs to a class of compounds known as benzazepines. These compounds possess unique structural characteristics and have garnered interest in various fields, including medicinal chemistry and pharmacology. Here are some engaging facts about this compound:

  • Pharmacological Implications: The benzazepine scaffold is often associated with various biological activities, including potential applications as antipsychotic agents and in the treatment of neurological disorders.
  • Chirality: This compound contains chiral centers, allowing for the possibility of different stereoisomers. The specific stereochemistry can significantly influence the biological activity and pharmacokinetic properties of the compound.
  • Substituent Effects: The presence of the chlorine atom and the methyl and phenyl groups can greatly affect the compound's electronic properties and reactivity, making it an interesting subject for synthetic chemists.
  • Research Interest: As part of ongoing research, compounds like this benzazepine derivative are explored for their potential therapeutic applications, particularly in treatments that address mood disorders and cognitive dysfunction.
  • Structural Diversity: The tetrahydro and aromatic components provide a rich structural diversity that can lead to the development of novel compounds with tailored properties for specific applications.

Overall, the study of 8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol exemplifies the intricate relationship between chemical structure and biological function. Its exploration continues to inspire scientists to examine how such compounds can be optimized for advancements in medicinal chemistry.

Synonyms
7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
[3H]-SCH23390
8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol
CHEBI:73297
95191-55-2
8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
SCH23390
Sch 23388
R-(+)-SCH-23390
[3H]SCH-23390
GTPL943
GTPL946
CHEMBL13668
SCHEMBL5722114
BDBM86180
DTXSID60873373
GOTMKOSCLKVOGG-UHFFFAOYSA-N
NSC_5018
PDSP1_001507
PDSP2_001491
CAS_87075-17-0
AG-205/08399048
L000549
Q7389148
8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-o