Interesting facts
Interesting Facts about 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, often abbreviated as a complex name, is a fascinating compound in the realm of medicinal chemistry and pharmacology. Below are some engaging insights into this compound:
- Pharmacological Relevance: This compound belongs to the benzodiazepine family, which is renowned for its sedative, anxiolytic, and muscle relaxant properties. Its structure suggests potential for significant therapeutic effects.
- Chlorine's Role: The presence of chlorine in the structure often enhances biological activity. It can alter lipophilicity and influence how the drug interacts with biological membranes and targets in the body.
- Fluorine Substitution: The incorporation of fluorine into organic compounds typically modifies reactivity and pharmacokinetics. This specific substitution can enhance the binding affinity of the compound to certain receptors, potentially increasing its efficacy.
- Imidazole Integration: The imidazo ring system in this compound is integral to its activity. Imidazole derivatives are of great interest due to their role in various biological processes, often acting as signaling molecules in the body.
- Research Potential: Scientists are interested in compounds like this one for their ability to modulate neurotransmitter systems, particularly in the context of disorders such as anxiety and depression. The ongoing research could lead to the development of novel therapeutic agents.
To summarize, the unique structural features and potential applications of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine make it a compound of significant interest. Its ongoing study could unveil new pathways in drug development, inspiring a new generation of treatments.
Synonyms
midazolam
Dormicum
59467-70-8
Buccolam
Midazolamum
Versed
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
mezolam
Midazolamum [INN-Latin]
Midazolam Base
Nayzilam
Midazolam civ
USL261
Ro 21-3981
DEA No. 2884
UNII-R60L0SM5BC
EINECS 261-774-5
R60L0SM5BC
BRN 0625572
CHEBI:6931
USL-261
CHEMBL655
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
DTXSID5023320
HSDB 6751
Midazolam [USP:INN:BAN:JAN]
USL261 (nasal spray formulation)
4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
Midazolamum (INN-Latin)
MIDAZOLAM (MART.)
MIDAZOLAM [MART.]
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
MIDAZOLAM CIV (USP-RS)
MIDAZOLAM CIV [USP-RS]
MIDAZOLAM (EP MONOGRAPH)
MIDAZOLAM [EP MONOGRAPH]
MIDAZOLAM (USP MONOGRAPH)
Midazolam (USP:INN:BAN:JAN)
MIDAZOLAM [USP MONOGRAPH]
Midazolam (1.0 mg/mL in methanol)
8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(1,5-a)(1,4)benzodiazepine
4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE, 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL
Dormicum (TN)
12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
NCGC00168254-01
Medazolam
Buccolam (TN)
Nayzilam (TN)
08J
Midazolamum (Latin)
Versed (Salt/Mix)
Dormonid (Salt/Mix)
Hypnovel (Salt/Mix)
Flormidal (Salt/Mix)
MIDAZOLAM [INN]
MIDAZOLAM [JAN]
MIDAZOLAM [MI]
MIDAZOLAM [VANDF]
MIDAZOLAM [WHO-DD]
Midazolam (JAN/USP/INN)
Midazolam Injection, 10 mg
SCHEMBL35061
BIDD:GT0647
Midazolam hydrochloride, solid
Midazolam, 1mg/ml in Methanol
DTXCID503320
GTPL3342
MIDAZOLAM [ORANGE BOOK]
BDBM21363
N05CD08
Midazolam 0.1 mg/ml in Methanol
Midazolam 1.0 mg/ml in Methanol
BCP21296
HY-B0676
59467-70-8 (free)
AKOS015842580
DB00683
FM25999
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
MIDAZOLAM IN 0.8% SODIUM CHLORIDE
MIDAZOLAM IN 0.9% SODIUM CHLORIDE
DB-015270
NS00000476
C07524
D00550
A832332
Q423071
Midazolam hydrochloride, United States Pharmacopeia (USP) Reference Standard
12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,8,10,12-hexaene
261-774-5
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Dazolam;Dormicum
Solubility of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
The solubility of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (C18H13ClFN3) can be influenced by a variety of factors, including its chemical structure and the nature of solvents used. Here are some key considerations regarding its solubility:
In many cases, compounds like this may exhibit limited solubility in water, which is a common characteristic of benzodiazepine derivatives due to their complex aromatic structures. For practical applications, understanding the solubility profile is essential, as it determines the compound's bioavailability, efficacy, and formulation characteristics in pharmaceutical contexts.
In summary, the solubility of C18H13ClFN3 can be summarized with the following points:
Emphasizing these aspects aids in understanding the behavior of this compound in various environments.