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Trazodone Hydrochloride

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Identification
Molecular formula
C19H22ClN5S
CAS number
25332-39-2
IUPAC name
8-chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine;chloride
State
State

This compound is generally found as a solid at room temperature.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
408.32g/mol
Molar mass
408.3180g/mol
Density
1.2505g/cm3
Appearence

The compound typically appears as a pale yellow crystalline powder. It is hygroscopic, meaning it absorbs moisture from the environment, and is often found in pharmaceutical formulations as a solid.

Comment on solubility

Solubility of 8-chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine;chloride

The solubility of 8-chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine;chloride can be quite intriguing due to the complex nature of its structure. This compound features a chloride ion, which typically enhances its solubility in polar solvents. Here are some key points regarding its solubility:

  • Solvent Interaction: Its solubility is likely to be high in polar solvents such as water and methanol due to the ionic nature introduced by the chloride.
  • Structural Groups: The presence of the piperazine moiety contributes to the hydrophilicity of the compound, which can further promote solubility.
  • Temperature Dependence: Like many chemical compounds, solubility can vary significantly with temperature, generally increasing as the temperature rises.
  • pH Sensitivity: Being a zwitterionic compound, its solubility might also be influenced by the pH of the solution, affecting its charge and, consequently, its solubility behavior.

Overall, one could say that the solubility characteristics of 8-chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine;chloride can be described as potentially good in a variety of polar solvents, making it a compound of interest in various applications.

Interesting facts

Interesting Facts about 8-Chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine; Chloride

This intriguing compound is a member of the benzothiazepine family, known for its diverse pharmacological activities. Its unique structure features two notable components: a chlorinated benzene ring and a piperazin-1-ium moiety. Here are some fascinating insights about this compound:

  • Pharmacological Properties: Compounds in the benzothiazepine class are often investigated for their potential as anxiolytics, antihypertensives, and antipsychotics. The substitution of the chlorine atom and the piperazine group enhances the compound's biological properties.
  • Ionization: The presence of the piperazin-1-ium group suggests that the compound is likely to be positively charged in solution, which can significantly affect its solubility and interaction with biological targets.
  • Structural Diversity: The variations in the benzothiazepine structure provide a rich field for synthetic chemists, allowing modifications that can lead to new compounds with desirable therapeutic effects.
  • Research Potential: Given its complex structure, this compound may serve as a lead molecule for drug development, inspiring further derivatives that can enhance efficacy and reduce side effects.

As emphasized by various researchers, compounds like this represent the intersection of chemistry and pharmacology, showcasing the importance of molecular modifications in developing effective therapeutic agents. The study of such compounds is not only vital for understanding mechanisms of action but also for advancing the field of medicinal chemistry.

In summary, 8-Chloro-6-(4-methylpiperazin-1-ium-1-yl)benzo[b][1,4]benzothiazepine; chloride illustrates the intricate relationship between chemical structure and biological function, making it a remarkable subject of study in modern chemistry.

Synonyms
HF-2159 hydrochloride
2-Chloro-11-(4'-methyl)piperazino-dibenzo(b,f)(1,4)thiazepine hydrochloride
4956-31-4
Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, hydrochloride