Interesting facts
Interesting Facts about 8-Chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine
This intriguing compound, known as 8-Chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine, has garnered attention in the field of medicinal chemistry due to its potential therapeutic applications. Here are some key points that highlight its significance:
- Structure & Functionality: This compound exhibits a complex, fused ring system, which is characteristic of benzodiazepine derivatives. Such structures often contribute to their biological activity, making them suitable for various pharmacological purposes.
- Neuropsychopharmacology: The presence of the piperazine moiety is of particular interest, as it is associated with anxiolytic (anti-anxiety) and antidepressant effects in many pharmaceutical compounds.
- Chloro Substitution: The incorporation of chlorine in the structure enhances lipophilicity, which can improve the compound's ability to cross biological membranes, potentially leading to increased efficacy in therapeutic applications.
- Psychoactive Properties: Compounds related to benzoxazepine have been explored for their action on neurotransmitter systems, particularly regarding their influence on serotonin and dopamine receptors, which are crucial in mood regulation and cognition.
Due to its intricate structure and the potential it holds for medicinal use, the exploration of 8-Chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine continues to be a fascinating area of research. Scientists aim to uncover the full range of its biological effects and assess its viability as a novel therapeutic agent.
As I often say: "The beauty of chemistry lies in its ability to provide solutions to the most pressing health challenges." Each compound, no matter how complex, carries the potential to change lives.
Synonyms
amoxapine
14028-44-5
Asendin
Demolox
Moxadil
Amoxan
Desmethylloxapin
Amoxapina
Amoxapinum
Amoxepine
Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
CL 67772
CL-67772
2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
Amoxapinum [INN-Latin]
Amoxapina [INN-Spanish]
8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
amoxipine
MFCD00069210
CL-67,772
EINECS 237-867-1
UNII-R63VQ857OT
NSC-759559
BRN 0832057
CHEBI:2675
R63VQ857OT
DTXSID7022598
Desmethylloxapine
CL 67,772
DIBENZ(b,f)(1,4)OXAZEPINE, 2-CHLORO-11-(1-PIPERAZINYL)-
2-Chlor-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepin
Asendis
CHEMBL1113
2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
MLS000069371
DTXCID102598
Amoxapine [USAN:USP:INN:BAN:JAN]
NSC 759559
2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine
2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
NCGC00015004-09
Ascendin
SMR000058416
Amoxapinum (INN-Latin)
CAS-14028-44-5
Amoxapina (INN-Spanish)
AMOXAPINE (MART.)
AMOXAPINE [MART.]
AMOXAPINE (USP-RS)
AMOXAPINE [USP-RS]
AMOXAPINE (USP IMPURITY)
AMOXAPINE [USP IMPURITY]
AMOXAPINE (USP MONOGRAPH)
AMOXAPINE [USP MONOGRAPH]
(E)-2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
Amoxapine (USAN:USP:INN:BAN:JAN)
Asendin (TN)
SR-01000003001
2-Chloro-11-(piperazin-1-yl)dibenzo(b,f)(1,4)oxazepine
Amoxapin
Prestwick_503
Amoxapine (Standard)
KS-1197
Opera_ID_33
LOXAPINE_met006
Spectrum_000446
CPD000058416
AMOXAPINE [INN]
AMOXAPINE [JAN]
AMOXAPINE [MI]
Lopac-A-129
AMOXAPINE [USAN]
Prestwick0_000102
Prestwick1_000102
Prestwick2_000102
Prestwick3_000102
Spectrum2_001245
Spectrum3_001067
Spectrum4_001218
Spectrum5_001284
AMOXAPINE [VANDF]
A-129
AMOXAPINE [WHO-DD]
Lopac0_000116
REGID_for_CID_2170
SCHEMBL33950
BSPBio_000084
BSPBio_002654
GTPL201
KBioGR_001656
KBioSS_000926
DivK1c_000236
SPECTRUM2300161
Amoxapine - Bio-X trade mark
SPBio_001150
SPBio_002023
Amoxapine (JP17/USP/INN)
Amoxapine, 1mg/ml in Methanol
BPBio1_000094
AMOXAPINE [ORANGE BOOK]
2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine
8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine
BDBM22870
HMS500L18
HY-B0991R
KBio1_000236
KBio2_000926
KBio2_003494
KBio2_006062
KBio3_001874
N06AA17
NINDS_000236
HMS1568E06
HMS2089G10
HMS2093N08
HMS2095E06
HMS2231E13
HMS3259G08
HMS3260G14
HMS3370P03
HMS3712E06
Pharmakon1600-02300161
HY-B0991
Tox21_110064
Tox21_302352
Tox21_500116
CCG-39135
NSC759559
PDSP1_001609
PDSP2_001593
s4218
AKOS015895092
Tox21_110064_1
AC-5495
CS-4485
DB00543
FA17884
LP00116
NC00546
SDCCGSBI-0050104.P004
IDI1_000236
NCGC00015004-01
NCGC00015004-02
NCGC00015004-03
NCGC00015004-04
NCGC00015004-05
NCGC00015004-06
NCGC00015004-07
NCGC00015004-08
NCGC00015004-10
NCGC00015004-11
NCGC00015004-13
NCGC00015004-16
NCGC00015004-22
NCGC00023887-03
NCGC00023887-04
NCGC00023887-05
NCGC00023887-06
NCGC00255124-01
NCGC00260801-01
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
BA164170
SY052450
SBI-0050104.P003
A2499
EU-0100116
NS00010454
D00228
EN300-123014
Q58356
T70258
AB00052421-13
AB00052421_14
AB00052421_15
L001293
SR-01000003001-2
SR-01000003001-4
SR-01000003001-6
8-chloro-6-piperazin-1-ylbenzo[b][1,5]benzoxazepine
BRD-K02265150-001-05-9
BRD-K02265150-001-15-8
BRD-K02265150-001-25-7
BRD-K02265150-001-26-5
BRD-K02265150-001-27-3
2-Chloro-11-(1-piperazinyl)dibenz[b,f]-1,4-oxazepine
2-Chloro-11-(1-piperazinyl)dibenzo[b,f]-1,4-oxazepine
2-Chloro-11-piperazin-1-yl-dibenzo[b,f][1,4]oxazepine
2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine #
Amoxapine, 1.0 mg/mL in methanol, certified reference material
Amoxapine, United States Pharmacopeia (USP) Reference Standard
Dibenzo[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
LOXAPINE SUCCINATE IMPURITY, AMOXAPINE- [USP IMPURITY]
LOXAPINE SUCCINATE IMPURITY, AMOXAPINE-(USP IMPURITY)
2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine;CL-67772;Asendin
2-Chloro-11-(1-piperazinyl)dibenz[b.f][1,4]oxazepine;CL-67772;Asendin
Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene
237-867-1
Solubility of 8-Chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine (C21H19ClN2O)
The solubility of 8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine in various solvents exhibits noteworthy characteristics:
In summary, while 8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine is not highly soluble in water, its improved solubility in polar organic solvents points to its potential applications in pharmaceutical formulations where solubility plays a critical role. Understanding these solubility properties is essential for optimizing the compound's bioavailability and therapeutic effectiveness.