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Coumestrol

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Identification
Molecular formula
C15H10O4
CAS number
479-13-0
IUPAC name
8-[(dimethylamino)methyl]-4-hydroxy-3-methyl-2-phenyl-chromen-7-one
State
State

At room temperature, coumestrol typically exists as a solid. Its crystalline nature can be readily observed under suitable laboratory conditions, contributing to its utility in various analytical applications.

Melting point (Celsius)
314.00
Melting point (Kelvin)
587.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
268.30g/mol
Molar mass
268.2990g/mol
Density
1.3400g/cm3
Appearence

Coumestrol is a yellow crystalline solid. It often appears as pale yellow or yellow powder when prepared for laboratory or medicinal use. Its coloration can facilitate its identification and differentiation from other similar compounds.

Comment on solubility

Solubility of 8-[(dimethylamino)methyl]-4-hydroxy-3-methyl-2-phenyl-chromen-7-one

The solubility of 8-[(dimethylamino)methyl]-4-hydroxy-3-methyl-2-phenyl-chromen-7-one exhibits intriguing characteristics influenced by its chemical structure and functional groups. Understanding the solubility of this compound involves examining several key factors:

  • Polar vs. Non-Polar Characteristics: The presence of both polar and non-polar groups in the structure suggests varying solubility in solvents. The hydroxyl group (–OH) typically enhances solubility in polar solvents, while the phenyl and dimethylamino moieties can impart non-polar characteristics.
  • Hydrogen Bonding: The –OH group may allow the compound to engage in hydrogen bonding with water, contributing to its solubility in aqueous solutions. Compounds that can form hydrogen bonds are often more soluble.
  • Effects of pH: Solubility can vary with pH due to ionization of the dimethylamino group. Under certain conditions, this group can become protonated, affecting overall solubility in different pH environments.
  • Temperature Dependence: Like many organic compounds, temperature changes can impact solubility; increasing temperature usually results in increased solubility in many cases.

In summary, while this compound may display *limited solubility in water*, it is anticipated to be more soluble in *organic solvents* due to its overall structure. This unique blend of characteristics speaks to the *intricacies of solubility*, highlighting the crucial role that molecular structure plays in determining the behavior of chemical compounds in various solvents.

Interesting facts

Interesting Facts about 8-[(Dimethylamino)methyl]-4-hydroxy-3-methyl-2-phenyl-chromen-7-one

This intriguing compound is part of the flavonoid family, specifically a subclass known for their diverse biological activities. Here are some fascinating aspects of this compound:

  • Biological Significance: Flavonoids are well-known for their antioxidant properties. They play a crucial role in protecting cells from oxidative stress, which can lead to various diseases.
  • Medicinal Applications: The structural features of this compound suggest potential therapeutic applications, particularly in fields such as anti-inflammatory and anticancer research.
  • Solubility: Compounds like this can often exhibit variable solubility in different solvents, which highlights their utility in various chemical applications and drug formulations.
  • Structure-Activity Relationship: The presence of the dimethylamino group may enhance its pharmacological properties, making it a point of interest for medicinal chemists exploring structure-activity relationships.

Many researchers emphasize the importance of flavonoids in diet as they have been linked to improved health, potentially reducing the risk of chronic diseases. According to a study, “Flavonoids have a profound effect on physiological processes, including antihypertensive and cholesterol-lowering effects.” Such insights portray the relevance of this compound not just in laboratories but also in our daily lives.

Continued exploration of compounds like this brings forward exciting possibilities in natural products chemistry and opens pathways for developing new medicinal compounds that can help combat various health challenges. The journey through the world of flavonoids is indeed a blend of chemistry and biology that fascinates scientists globally.