Skip to main content

Dantrolene

ADVERTISEMENT
Identification
Molecular formula
C14H10N4O5
CAS number
7261-97-4
IUPAC name
8-[hydroxy-phenyl-(2-pyridyl)methyl]-10-[phenyl(2-pyridyl)methylene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
State
State

At room temperature, Dantrolene is a solid. It exists as a crystalline powder, and given its appearance and physical properties, it requires careful handling, especially for uses in pharmaceuticals where purity and stability are essential considerations.

Melting point (Celsius)
288.50
Melting point (Kelvin)
561.65
Boiling point (Celsius)
437.00
Boiling point (Kelvin)
710.15
General information
Molecular weight
314.25g/mol
Molar mass
314.2270g/mol
Density
1.2906g/cm3
Appearence

Dantrolene is typically found as a yellow to orange crystalline powder. It is almost insoluble in water and sparingly soluble in alcohol. Dantrolene's appearance as a powder means it can be sensitive to light, requiring storage in a dark, dry place to maintain its stability.

Comment on solubility

Solubility Characteristics of 8-[hydroxy-phenyl-(2-pyridyl)methyl]-10-[phenyl(2-pyridyl)methylene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

The solubility of complex organic compounds, like 8-[hydroxy-phenyl-(2-pyridyl)methyl]-10-[phenyl(2-pyridyl)methylene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, can be quite variable and is influenced by several factors. Here are some key points to consider:

  • Polarity: The presence of hyroxy (-OH) groups tends to enhance solubility in polar solvents like water, while the aromatic components may favor solubility in non-polar organic solvents.
  • Hydrogen Bonding: This compound is likely capable of engaging in hydrogen bonding due to its hydroxy group, which could increase its solubility in polar solvents.
  • Structural Complexity: The intricate structure may lead to varied interactions with solvents, affecting overall solubility.
  • pH Sensitivity: The solubility might also vary with changes in pH, particularly if the compound can form charged species that are more soluble at certain pH levels.

As a general note, “the solubility of a compound is a hallmark that dictates its suitability for applications across various domains, from pharmaceutical formulations to analytical chemistry”. This specific compound may exhibit preferential solubility in certain organic solvents over others, and determining the precise solubility would require empirical measurements and detailed analysis.

Interesting facts

Discovering 8-[Hydroxy-phenyl-(2-pyridyl)methyl]-10-[phenyl(2-pyridyl)methylene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

This fascinating compound features a complex structure that integrates multiple functional groups, making it a subject of significant interest within the field of organic chemistry. Here are some engaging insights about this compound:

  • Structural Diversity: The unique arrangement of phenyl and pyridyl groups contributes to the compound's intriguing properties, enhancing its potential for various applications in medicinal chemistry.
  • Biological Significance: Compounds with similar structures have been studied for their potential biological activities, including anti-cancer and anti-inflammatory effects. This makes them valuable candidates for drug development.
  • Research Applications: Scientists are increasingly interested in synthesizing and characterizing compounds like this one for their use as building blocks in the design of novel materials and as ligands in coordination chemistry.
  • Chirality and Regioselectivity: The presence of multiple aromatic rings may introduce fascinating aspects of chirality, influencing the compound's behavior in biological systems and its interactions with other molecules.

In conclusion, the depth of investigation into compounds such as 8-[hydroxy-phenyl-(2-pyridyl)methyl]-10-[phenyl(2-pyridyl)methylene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione reflects the vibrant nature of modern chemistry research.

Synonyms
NORBORMIDE
Raticate
Shoxin
Mcneil 1025
991-42-4
Compound S-6,999
MCN 1025
ENT 51,762
NORBORMIDE [MI]
NORBORMIDE [ISO]
NORBORMIDE [HSDB]
S 6999
S-6,999
K4085589CZ
DTXSID8042216
NSC-101316
4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-5-(hydroxyphenyl-2-pyridinylmethyl)-8-(phenyl-2-pyridinylmethylene)-
5-Norbornene-2,3-dicarboximide, 5-(alpha-hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)-
Compound S 6999
5-((.ALPHA.-HYDROXY-.ALPHA.-2-PYRIDYL)BENZYL)-7-(.ALPHA.-(2-PYRIDYL)BENZYL)-5-NORBORNENE-2,3-DICARBOXIMIDE
5-(.alpha.-Hydroxy-.alpha.-2-pyridylbenzyl)-7-(.alpha.-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide
Raticide
Compound S6,999
DTXCID00809772
EHT 51762
5-Norbornene-2,3-dicarboximide, 5-(.alpha.-hydroxy-.alpha.-2-pyridylbenzyl)-7-(.alpha.-2-pyridylbenzylidene)-
C 6999
S6,999
5Norbornene2,3dicarboximide, 5(alphahydroxyalpha2pyridylbenzyl)7(alpha2pyridylbenzylidene)
213-589-6
4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-5-(hydroxyphenyl-2-pyridinylmethyl)-8-(phenyl-2-pyridinylmethylene)-(9CI)
4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE,3A,4,7,7A-TETRAHYDRO-5-(HYDROXYPHENYL-2-PYRIDINYLMETHYL)-8-(PHENYL-2-PYRIDINYLMETHYLENE)-
4,7Methano1Hisoindole1,3(2H)dione, 3a,4,7,7atetrahydro5(hydroxyphenyl2pyridinylmethyl)8(phenyl2pyridinylmethylene)
5-((ALPHA-HYDROXY-ALPHA-2-PYRIDYL)BENZYL)-7-(ALPHA-(2-PYRIDYL)BENZYL)-5-NORBORNENE-2,3-DICARBOXIMIDE
5-(alpha-Hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide
Nobormide
Caswell No. 606
Nobormide [ISO-French]
Norbormide [ANSI:ISO]
8-(hydroxy-phenyl-pyridin-2-ylmethyl)-10-[phenyl(pyridin-2-yl)methylidene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
HSDB 1743
EINECS 213-589-6
EPA Pesticide Chemical Code 086201
NSC 101316
AI3-51762
MFCD01632784
UNII-K4085589CZ
5-Norbornene-2,3-dicarboximide, 5-(alpha-hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)
CHEMBL388119
SCHEMBL15273055
CHEBI:82259
DNTHHIVFNQZZRD-UHFFFAOYSA-N
DB-057760
HY-122331
CS-0083940
C19139
4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, 3A,4,7,7A- TETRAHYDRO-5-(HYDROXYPHENYL-2-PYRIDINYLMETHYL)-8-(PHENYL-2- PYRIDINYLMETHYLENE)-
5-NORBORNENE-2,3-DICARBOXIMIDE, 5-(.ALPHA.-HYDROXY-.ALPHA.-2- PYRIDYLBENZYL)-7-(.ALPHA.-2-PYRIDYLBENZYLIDENE)-