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Ipratropium Bromide

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Identification
Molecular formula
C20H30BrNO3
CAS number
22254-24-6
IUPAC name
(8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate;bromide
State
State

At room temperature, Ipratropium Bromide is typically in a solid state.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
430.38g/mol
Molar mass
430.3750g/mol
Density
1.3040g/cm3
Appearence

Ipratropium Bromide typically appears as a white crystalline powder. It is odorless in nature.

Comment on solubility

Solubility of (8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate; bromide

The compound (8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate; bromide displays intriguing solubility characteristics that can be primarily attributed to its structural features.

Solubility Factors

Understanding the solubility of this compound involves considering various aspects:

  • Polarity: The presence of the bromide ion and the hydroxy group can enhance water solubility due to their polar nature.
  • Hydrophobic Regions: The bulky isopropyl and methyl groups contribute to hydrophobic interactions, which may reduce solubility in polar solvents.
  • Ionization: The azabicyclic structure may facilitate ion formation in solution, further influencing solubility behavior.

General Observations

In general, one can observe that:

  • Solubility in water may be moderate due to the dual nature of substituents.
  • In organic solvents, solubility may increase, particularly in less polar solvents due to hydrophobic interactions.

As with many complex organic compounds, experimental validation is essential to fully understand its solubility profile. Hence, it is advisable to conduct solubility tests under various conditions to capture the nuances of its behavior in different solvents.

Interesting facts

Interesting Facts about (8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate; bromide

This unique compound, commonly referred to in chemical literature, is a member of the bicyclic ammonium compounds. It presents a fascinating structure that combines components from various chemical classrooms:

  • Bicyclo Structure: The bicyclo[3.2.1] framework provides a three-dimensional space that is crucial in various biological systems and synthetic applications.
  • Quaternization: The presence of the azoniabicyclo group indicates that this compound is a quaternary ammonium salt. Quaternary amines are known for their unique properties, such as strong ionic character and hydrophilicity.
  • Biological Relevance: Compounds like these are often used in pharmacology, with potential applications ranging from anticholinergic agents to complex receptor interactions.
  • Synthesis Challenges: The synthesis of such complex structures often involves multi-step reactions that can be challenging yet rewarding from a synthetic chemistry perspective.
  • Applications in Chemistry: Beyond pharmaceuticals, compounds of this nature are useful in catalysis and can serve as ligands in coordination chemistry.

As a student of chemistry, one might consider the following:

  1. What are the implications of the bicyclic structure on the compound's reactivity?
  2. How does the azoniabicyclo influence its solubility in biological systems?
  3. Can this compound be modified to enhance its pharmacological properties?

In conclusion, the compound can be seen as a key player in both theoretical discussions and practical applications within chemistry, representing a rich area for exploration and discovery. As one researcher eloquently stated, "The beauty of chemical compounds lies not just in their structure, but in the myriad of possibilities they hold."

Synonyms
ipratropium bromide
58073-59-9
Ipratropii bromidum
8-anti-Ipratropium Bromide
(8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;bromide
Aerovent
Apovent
(endo,anti)-(+/-)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide
CHEMBL1237108
MFCD00792907
C20H30BrNO3
SCHEMBL3853
MLS006009993
Ipratropium Bromide Impurity 33
LHLMOSXCXGLMMN-UHFFFAOYSA-M
HMS1569D12
HMS3266J19
HMS3371M05
HMS3411B05
HMS3651O15
HMS3675B05
HMS3884K06
HMS5079D12
Ipratropium EP Impurity B Bromide
BCP25720
BCP33467
s1683
AKOS015994717
AKOS025147299
CCG-268790
KS-5051
NCGC00094701-01
NCGC00094701-02
(endo,syn)-(+/-)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide
2784-21-6
SMR004701068
I0907
SW196584-2
SR-01000597818
SR-05000001657
(1s,3s,5r)-3-tropyloxy-8-isopropyltropaniumbromide
SR-01000597818-1
SR-05000001657-1
(8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate;bromide
(endo,anti)-( inverted exclamation markA)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide