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Pipamperone

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Identification
Molecular formula
C17H19N3S
CAS number
1893-33-0
IUPAC name
8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
State
State

State at Room Temperature: Pipamperone is a solid at room temperature. It is typically used in its hydrochloride salt form for ease of use in pharmaceutical formulations.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
700.00
Boiling point (Kelvin)
973.15
General information
Molecular weight
353.47g/mol
Molar mass
353.4660g/mol
Density
1.3200g/cm3
Appearence

Pipamperone typically appears as a crystalline solid, which is white or off-white in color. The compound is odorless and is usually supplied in powder form for pharmaceutical uses.

Comment on solubility

Solubility of 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine

The solubility of 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine can be quite intriguing due to its complex structure. This compound, like many others in the same chemical class, exhibits variable solubility depending on the solvent used. Here are some key points to consider:

  • Polarity: The presence of polar groups, such as the methylpiperazine moiety, can enhance solubility in polar solvents like water.
  • Solvent Compatibility: It is more soluble in organic solvents, such as methanol or ethanol, owing to its hydrophobic aromatic regions.
  • Temperature Effects: Increased temperature typically improves the solubility of most compounds; thus, this compound may dissolve better at higher temperatures.
  • pH Sensitivity: Adjusting the pH of the solution can also impact solubility, particularly for compounds containing basic or acidic functional groups.

As stated, "The solubility characteristics of a compound are essential for its application in pharmaceuticals." Understanding these traits not only aids in drug formulation but also influences the bioavailability of the compound in biological systems. Therefore, conducting detailed solubility studies across different conditions will yield a comprehensive understanding of how to effectively utilize this unique chemical structure in various applications.

Interesting facts

Interesting Facts about 8-Methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine

This compound belongs to a class of organic molecules known as benzothiazepines, which are noted for their diverse pharmacological properties. Here are some intriguing aspects of this particular compound:

  • Pharmacological Significance: Benzothiazepines, including this specific derivative, are often explored for their potential use in treating various ailments, particularly in the realms of psychiatry and neurology. They have been identified for their effects as anxiolytics and antidepressants.
  • Cyclic Structure: The presence of both a benzene ring and a thiazepine ring contributes to the compound's unique structural characteristics. The cyclic arrangement not only impacts its physical properties but also its reactivity and biological activity.
  • Substituent Influence: The addition of the methyl group and the piperazine moiety might enhance the lipophilicity of this compound, influencing its ability to cross biological membranes and bind to various receptors in the brain.
  • Research Interest: As part of ongoing research, compounds like this one are often evaluated in drug design studies aimed at developing more effective treatment options for conditions such as anxiety disorders, schizophrenia, and even certain types of pain management.
  • Versatile Chemistry: The chemistry of benzothiazepines is rich and varied, allowing chemists to synthesize numerous analogs that may exhibit distinct biological activities, which is a prime consideration in medicinal chemistry.

In summary, 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine exemplifies the fascinating interplay between structure and function in medicinal compounds. The ongoing studies into its pharmacological applications could lead to significant advancements in therapeutic modalities, making it a compound of considerable interest in the field of pharmaceutical sciences.

Synonyms
Metiapine
5800-19-1
Metiapina
8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
775D6D91J8
2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine
DIBENZO(b,f)(1,4)THIAZEPINE, 2-METHYL-11-(4-METHYL-1-PIPERAZINYL)-
Metiapina [INN-Spanish]
Metiapinum
Metiapine [USAN:INN]
Metiapinum [INN-Latin]
2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine
BRN 0833849
UNII-775D6D91J8
METIAPINE [INN]
Metiapine (USAN/INN)
METIAPINE [USAN]
SCHEMBL121263
CHEMBL2106892
DTXSID7020891
2-methyl-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine
NS00122288
D02672
Q27266552