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Clopidogrel hydrobromide

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Identification
Molecular formula
C16H17ClNO2·HCl
CAS number
120202-66-6
IUPAC name
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenyl)prop-2-enoate;hydrochloride
State
State
At room temperature, clopidogrel hydrobromide is in a solid state. It should be stored in a well-sealed container due to its hygroscopic nature.
Melting point (Celsius)
184.00
Melting point (Kelvin)
457.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
420.90g/mol
Molar mass
420.9000g/mol
Density
1.3379g/cm3
Appearence

Clopidogrel hydrobromide appears as a white to off-white crystalline powder. It is highly hygroscopic, meaning it readily absorbs moisture from the atmosphere.

Comment on solubility

Solubility of (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenyl)prop-2-enoate; hydrochloride

The solubility of this compound is significantly influenced by its chemical structure, particularly the presence of the hydrochloride salt. In general, salts tend to have higher solubility in water compared to their parent bases. Key characteristics of this compound's solubility include:

  • Polar Functional Groups: The hydrochloride form likely increases polarity, promoting solubility in polar solvents, particularly water.
  • Hydrochloride Influence: The presence of the HCl moiety can lead to enhanced solubility due to the formation of hydrogen bonds with water molecules.
  • Alkyl and Aryl Groups: The substitution of the 4-chlorophenyl group may affect the solubility, where aromatic groups can generally decrease solubility due to their hydrophobic nature.

In summary, while the compound can be expected to demonstrate good solubility owing to the hydrochloride form, the presence of hydrophobic substituents may create challenges in achieving maximum solubility in aqueous environments. It can be quoted that “the balance between hydrophilic and hydrophobic characteristics is crucial in determining overall solubility.”

Interesting facts

Interesting Facts about (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenyl)prop-2-enoate; hydrochloride

As a member of the bicyclic compound family, (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenyl)prop-2-enoate; hydrochloride showcases the fascinating intersection of organic chemistry and pharmacology. Here’s why this compound is captivating:

  • Unique Structure: The bicyclic structure of this compound makes it a subject of interest in the study of stereochemistry.
  • Pharmacological Potential: Compounds like this one are often explored for their potential therapeutic uses, especially in neurology and psychiatry. They may exhibit properties beneficial for treating various cognitive disorders.
  • Chirality: The presence of chiral centers in its structure allows for the potential of isomeric variations, which can significantly alter biological activity.
  • Substituent Effects: The 4-chlorophenyl group introduces interesting electronic and steric effects, which can influence the compound's reactivity and interaction with biological targets.

In the realm of drug design, the exploration of such compounds often leads researchers to draw insights into:

  1. The interplay between chemical structure and biological activity.
  2. The development of targeted therapies that minimize side effects.
  3. How modifications in the molecular structure can enhance pharmacokinetic properties.

As one dives deeper into the world of chemical compounds, the study of derivatives like 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(4-chlorophenyl)prop-2-enoate; hydrochloride can reveal profound implications in drug discovery, offering a glimpse into the complex mechanisms of life itself.

Synonyms
3-Tropanyl 2-(p-chlorophenyl)acrylate hydrochloride
SKF 21000
6746-91-4
SK&F 21000
3-Tropanyl 4'-chloroatropate hydrochloride
4'-Chloroatropic acid, 3-tropanyl ester, hydrochloride
1-alpha,5-alpha-Tropan-3-ol, p-chloroatropate (ester), hydrochloride
3-Tropanyl-2-(p-chlorophenyl)acrylate hydrochloride
Atropic acid, p-chloro-, 1-alpha-H,5-alpha-H-tropan-3-alpha-yl ester, hydrochloride
SK&F-21000
ATROPIC ACID, 4'-CHLORO-, 3-TROPANYL ESTER, HYDROCHLORIDE
3-tropanyl-2-(p-chlorophenyl)acrylate.HCl
Atropic acid, p-chloro-, 1-alpha-H,5-alpha-H-tropan-3-alpha-yl ester, hydrochloride (8CI)
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenyl)prop-2-enoate;hydrochloride
DTXSID50986729
Atropic acid, p-chloro-, tropyl ester, hydrochloride
8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(4-chlorophenyl)prop-2-enoate--hydrogen chloride (1/1)