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Benztropine

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Identification
Molecular formula
C21H25NO1
CAS number
86-13-5
IUPAC name
(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-acetate
State
State

Benztropine is typically found in a solid state at room temperature. It is stable under normal conditions and used primarily in medicinal applications.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.00
Boiling point (Celsius)
429.40
Boiling point (Kelvin)
702.60
General information
Molecular weight
307.41g/mol
Molar mass
307.4050g/mol
Density
1.1529g/cm3
Appearence

Benztropine typically appears as a white crystalline powder. It is often odorless and has a crystalline structure that is characteristic of many organic compounds used in medicinal preparations.

Comment on solubility

Solubility of (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-acetate

The solubility of the compound (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-acetate can be quite intriguing due to its complex structure. In general, the solubility of a compound depends on several factors:

  • Polarity: The presence of polar functional groups, such as the hydroxyl group in this compound, suggests a degree of solubility in polar solvents like water.
  • Electrostatic Interactions: The azoniabicyclo structure can impart ionic characteristics, potentially enhancing solubility in polar solvents.
  • Molecular Size: Larger molecules tend to have lower solubility in solutions due to steric hindrance affecting interactions with solvents.
  • Hydrophobicity: The phenacyl and phenyl groups may contribute to hydrophobic characteristics, which can reduce solubility in water.

In organic solvents, such as ethanol or acetone, this compound may show greater solubility due to reduced intermolecular interactions compared to those experienced in water. Therefore, we can summarize that:

  • Likely soluble: in polar solvents due to polarity and ionic characteristics.
  • Likely less soluble: in non-polar solvents because of hydrophobic regions.

Understanding these solubility dynamics provides valuable insight into the practical applications of this compound in various chemical processes.

Interesting facts

Interesting Facts about (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-acetate

This compound is a remarkable example of the intricate connections between organic chemistry and pharmacology. Its structure features a bicyclic framework that contributes significantly to its behavior and reactivity. Here are some notable aspects:

  • Complexity in Structure: The bicyclo[3.2.1]octane core creates a unique spatial arrangement that influences the compound's chemical interactions.
  • Azonium Group Impact: The presence of the azoniabicyclo moiety introduces positive charge, which can enhance solubility in polar solvents and affect the reactivity of the compound.
  • Pharmacological Potential: Compounds with similar frameworks are often explored for their therapeutic properties, including their potential as ion channels or neurotransmitter analogs.
  • Substitutive Chemistry: The substituents, such as the 2-hydroxy-2-phenyl-acetate group, offer prospects for further functionalization, which can lead to the discovery of new derivatives with varied biological activities.
  • Observations from Synthesis: The synthesis of such complex molecules can often reveal more about reaction mechanisms, selectivity, and the influence of sterics and electronics in organic reactions.

As a multidisciplinary compound, this fascinating molecule reminds chemists that studying its properties can lead not only to fundamental advancements in chemistry but also to practical applications in medicine and materials science.

Synonyms
SCHEMBL8916468
DTXSID20863275
3-{[Hydroxy(phenyl)acetyl]oxy}-8-methyl-8-(2-oxo-2-phenylethyl)-8-azabicyclo[3.2.1]octan-8-ium