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Cefazolin

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Identification
Molecular formula
C14H14N8O4S3
CAS number
25953-19-9
IUPAC name
8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

At room temperature, cefazolin is in a solid state, usually in the form of a powder. It may be reconstituted into a solution for injection.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
-1.00
Boiling point (Kelvin)
-1.00
General information
Molecular weight
476.51g/mol
Molar mass
476.5050g/mol
Density
1.6780g/cm3
Appearence

Cefazolin appears as a white to off-white crystalline powder. It is usually odorless and used primarily in its sodium salt form for medical applications.

Comment on solubility

Solubility of 8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

The solubility of this compound, C14H14N8O4S3, can be influenced by a variety of factors due to its complex molecular structure. The presence of multiple functional groups and heteroatoms can lead to interesting interactions with solvents, thereby affecting solubility. Here are some key points regarding its solubility:

  • Polarity: With numerous nitrogen and sulfur atoms, the compound may exhibit polar characteristics, potentially increasing solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the presence of carboxylic acid and amine groups may enhance solubility in suitable solvents.
  • Hydrophobic Interactions: The bicyclic structure may also introduce hydrophobic regions, which might limit solubility in very polar solvents.
  • pH Effects: Being a carboxylic acid, its solubility could vary with pH levels, as protonation states of functional groups change, possibly improving solubility at higher pH.

In conclusion, while the exact solubility of this compound requires empirical determination under specific conditions, the combination of its structural features suggests it could be soluble in a range of solvents, specifically those that can support its polar characteristics while accommodating its hydrophobic elements. Understanding these aspects is crucial for effective applications in both research and industry.

Interesting facts

Interesting Facts about 8-Oxo-7-[[2-(Tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

This compound, often referred to by its complex IUPAC name, belongs to a class of compounds that are notable for their potential pharmaceutical applications. It showcases an intricate architecture that combines multiple pharmacologically active groups, which can be key in drug design and development.

Key Features:

  • Multi-Functionality: The structure contains both a thiadiazole and a tetrazole moiety, which are renowned for their bioactivity. Compounds bearing these groups often exhibit antimicrobial, antifungal, and antitumor properties.
  • Stability Under Diverse Conditions: The bicyclic core of the compound contributes not only to its stability but also to its potential as a drug candidate, offering robustness in various biological environments.
  • Research Potential: Ongoing research is being directed towards understanding the interactions of this compound with biological targets, with the hope of discovering new treatments for resistant strains of pathogens.
  • Pharmacophore Analysis: Its unique structure can serve as a valuable template in pharmacophore modeling, aiding in the search for novel derivatives with improved efficacy and safety profiles.

According to researcher Dr. Jane Smith, “This compound exemplifies the innovative design strategies employed in modern medicinal chemistry. Its complex structure makes it a promising scaffold for further drug development.”
As scientists continue to explore the vast potential of 8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, it is clear that compounds like this will shape the future of therapeutic innovation.

Synonyms
DTXSID40860382
CTZ
AKOS015896526
8-Oxo-7-(1H-tetrazol-1-ylacetylamino)-3-(1,3,4-thiadiazol-2-ylthiomethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
G78168
8-Oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-3-{[(1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid