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Progesterone

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Identification
Molecular formula
C21H30O2
CAS number
57-83-0
IUPAC name
(8R,9R,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-17-(2-methylallyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, progesterone is a solid compound, existing as a crystalline powder.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
457.00
Boiling point (Kelvin)
730.15
General information
Molecular weight
314.47g/mol
Molar mass
314.4690g/mol
Density
1.0630g/cm3
Appearence

Progesterone is a white or creamy white, crystalline powder. It is practically insoluble in water, but can dissolve in alcohol, acetone, and other organic solvents.

Comment on solubility

Solubility of (8R,9R,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-17-(2-methylallyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of this complex organic compound is influenced by various factors such as its molecular structure and functional groups. Typically, it exhibits a low aqueous solubility due to the presence of large hydrophobic ring structures, which hinder interactions with water molecules. However, here are some key points to consider:

  • Hydrophilic vs. Hydrophobic: The compound contains both hydrophilic hydroxyl groups and predominantly hydrophobic portions, leading to limited solubility in water.
  • Solvent Compatibility: While it may have restricted solubility in polar solvents such as water, it tends to dissolve better in non-polar solvents like hexane or chloroform.
  • Temperature Effects: The solubility generally increases with temperature; thus, warm solvents can enhance its dissolution.
  • Concentration Considerations: At higher concentrations, aggregation may occur, impacting overall solubility behavior.

Understanding these aspects is crucial for the applications of this compound in various fields, including pharmaceuticals and organic chemistry. As a general statement, one can say that, "The solubility profile is a delicate balance of structural features and environmental conditions."

Interesting facts

Interesting Facts About (8R,9R,10S,13S,14S,17R)-17-Hydroxy-10,13-Dimethyl-17-(2-Methylallyl)-2,6,7,8,9,11,12,14,15,16-Decahydro-1H-Cyclopenta[a]phenanthren-3-One

This complex organic compound is a fascinating representative of the steroid hormone family. Here are some intriguing details:

  • Natural Origins: This compound is closely related to hormones produced in the human body, playing vital roles in various biological processes such as metabolism and immune response.
  • Structural Complexity: Its elaborate structure features multiple chiral centers, contributing to its stereochemistry and biological activity. This complexity challenges chemists in synthesis and characterization.
  • Pharmacological Potential: Due to its steroid-like structure, this compound may exhibit pharmacological properties that can be explored for therapeutic uses, including anti-inflammatory and anabolic effects.
  • Research Interest: The unique arrangement of functional groups on the cyclopenta[a]phenanthrene backbone makes it of particular interest in medicinal chemistry, as small alterations in structure can lead to significant changes in activity and efficacy.
  • Biochemical Importance: Compounds of this type are essential for understanding mechanisms of action in both human health and disease, as they can help elucidate signaling pathways within cells.
  • Cultural Relevance: Steroids have been historically significant both in traditional medicine and contemporary sports, where they can be misused for performance enhancement, sparking debates on ethics and health.

The exploration of such compounds not only broadens our understanding of chemical and biological interactions but also inspires continued research in synthetic methods and potential applications. As we delve deeper into these molecular wonders, we uncover the secrets that nature has woven into its chemistry.

Synonyms
SCHEMBL3365605