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Progesterone

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Identification
Molecular formula
C21H30O2
CAS number
57-83-0
IUPAC name
(8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
State
State

At room temperature, Progesterone is a solid. It is typically presented in powder form for pharmaceutical and research purposes.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.20
Boiling point (Celsius)
403.00
Boiling point (Kelvin)
676.20
General information
Molecular weight
314.47g/mol
Molar mass
314.4690g/mol
Density
1.1700g/cm3
Appearence

Progesterone is a white crystalline powder. Its appearance is characterized by its fine texture and the fact that it is generally odorless. In some cases, it may appear as small, white to off-white crystals.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

This compound exhibits intriguing solubility characteristics that may influence its applications in various fields. Primarily, the solubility of organic compounds, such as this one, can be affected by several factors:

  • Polarity: Due to the presence of multiple hydrocarbon chains and keto groups, the polarity of the molecule plays a crucial role in its solubility. Typically, increased polarity might enhance solubility in polar solvents.
  • Solvent type: Solubility can vary significantly depending on whether the solvent is polar (like water) or non-polar (like hexane). This compound is likely more soluble in organic solvents than in water due to its predominantly hydrophobic nature.
  • Structural configuration: The bulky structure and spatial arrangement of substituents influence how well this compound interacts with solvent molecules, potentially affecting its solubility profile.

As a rule of thumb in chemistry, "like dissolves like." Thus, when considering its practical applications:

  1. In organic solvents: This compound is expected to have relatively good solubility.
  2. In polar solvents: Its solubility is anticipated to be limited.

Understanding the solubility of this compound is essential for optimizing its use in pharmaceutical formulations, chemical reactions, and material sciences. Further experimental studies would provide more precise solubility data to fully define its characteristics.

Interesting facts

Interesting Facts about (8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

This remarkable compound is a member of the class of molecules known as steroids, which play crucial roles in various biological processes. Steroids are characterized by their unique structure, and this compound exemplifies the complexity and diversity found within this class.

Biological Significance

Often referred to as a steroidal compound, it holds potential relevance in:

  • Hormonal Activity: Many steroid compounds, including derivatives of this structure, interact with specific receptors in cells, influencing metabolic processes and acting as hormones.
  • Medical Applications: Research indicates that similar compounds may have therapeutic effects, making them candidates for drug development and treatment protocols.

Synthesis and Modifications

This compound's intricate structure, featuring multiple chiral centers, showcases the challenge and art of organic synthesis. Highlights include:

  • The ability to achieve specific stereochemical configurations, which is vital for biological activity.
  • Modification of side chains and functional groups, leading to derivatives with varying properties.

Chemical Properties and Interactions

In chemical terms, the reactivity of this compound could provide insight into its behavior in different environments. Here are some aspects worth noting:

  • Functional Groups: The presence of diones in its structure makes it a target for various reactions, further expanding its utility in synthetic chemistry.
  • Environmental Impact: Understanding how compounds like this one interact with biological systems and their potential environmental persistence is critical for developing eco-friendly practices in chemical synthesis.

Overall, the intricate and nuanced nature of (8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione exemplifies the complexity of organic chemistry. Its exploration opens the door to numerous scientific avenues, enhancing our understanding of both fundamental chemistry and its practical applications in health and medicine.

Synonyms
androsta-1,4-diene-3,17-dione
Boldione
1,4-Androstadiene-3,17-dione
897-06-3
Androstadienedione
1-Dehydroandrostenedione
ANDROSTA-1,4-DIEN-3,17-DIONE
NSC 49080
EINECS 212-977-2
CHEBI:40799
Androstane-1,4-diene-3,17-dione
(+)-Androsta-1,4-diene-3,17-dione
.DELTA.1,4-Androstadiene-3,17-dione
2166Q8568W
DTXSID00862463
EC 212-977-2
NSC-49080
J38.935H
TESTOSTERONE IMPURITY G [EP IMPURITY]
(1S,2R,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,14-dione
TESTOSTERONE IMPURITY G (EP IMPURITY)
androst-1,4-diene-3,17-dione
(1S,2R,10R,11S,15S)-2,15-dimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-3,6-diene-5,14-dione
DTXCID001773032
delta1,4-Androstadiene-3,17-dione
212-977-2
Androstra-1,4-diene-3,17-dione
(8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
Boldione (1.0mg/ml in Acetonitrile)
ANB
ANDROSTENEDONE
Androsta-1,4-diene-3,17-dione (Androstadienedione)
Androstadiendione
UNII-2166Q8568W
MLS002207247
SCHEMBL134061
1,4-Androstadien-3,17-dione
CHEMBL1078534
BDBM91718
1h62
BCP28281
Androsta-1,4-diene-3, 17-dione
BBL033692
MFCD00003614
STK801872
Androst-1,4-dien-3,17-dione, 7
Androstane-1,4-diene-3, 17-dione
AKOS005622723
DB07373
FB18999
SMR000112159
VS-12222
EXEMESTANE IMPURITY D [EP IMPURITY]
A0856
C20144
(8alpha,14beta)-androsta-1,4-diene-3,17-dione
A843288
Q4939115
Androsta-1,4-diene-3,17-dione;1-Dehydroandrostenedione;1,4-Androstadiene-3,17-dione
(3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,7-dione
(8R,10R,13S)-10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione