Interesting facts
Interesting Facts about (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
This complex organic compound is a fascinating example of a bicyclic structure with significant biological implications. It is often studied for its potential pharmacological properties, particularly in the realm of hormone regulation and anti-cancer activities. Here are a few noteworthy points that shed light on its significance:
- Steroidal Backbone: This compound's structure is intricately linked to the steroid family, which plays crucial roles in biological processes. Steroids are vital for various functions, including metabolism, immune response, and reproductive regulation.
- Chirality: The existence of multiple chiral centers (8R, 9S, 10R, 13S, 14S) in this compound highlights its stereochemical complexity. Chirality can greatly influence the biological activity of compounds, making specific stereoisomers more effective than others.
- Hydroxyl Group Influence: The presence of a hydroxyl group at position 4 is significant as it may enhance solubility and bioactivity, affecting how the compound interacts with biological systems.
- Research Applications: Due to its steroid-like structure and the hydroxyl substitution, this compound is a subject of interest in medicinal chemistry, particularly for exploring new treatments for diseases such as cancer or hormonal disorders.
- Natural Sources: Compounds with similar structures often occur in nature, suggesting they could be derived from various natural sources, which makes them interesting targets for synthesis and study.
Overall, (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione is not just any chemical compound; it represents the intricate design of nature's chemistry and provides hope for advancements in pharmacological research.
Synonyms
formestane
566-48-3
4-Hydroxyandrost-4-ene-3,17-dione
4-Hydroxyandrostenedione
Lentaron
CGP-32349
Lentaron(R)
NSC 282175
4-OH-A
CGP 32349
ANDROST-4-ENE-3,17-DIONE, 4-HYDROXY-
B, Aromatase inhibitor
4-Hydroxy-4-androstene-3,17-dione
formestano
4-OHAD
NSC-282175
4-oh-androstene-3,17-dione
MLS000028826
MLS002153359
PUB9T8T355
(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
DTXSID3034113
CHEBI:75172
4-hydroxy-Delta(4)-androstenedione
Formestane (INN)
SMR000058722
FORMESTANE [INN]
17-dione
4-OHA
Formestane [INN:BAN]
(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione
CAS-566-48-3
CCRIS 7483
4-Hydroxy-delta(sub 4)-androstenedione
BRN 1889793
formestanum
UNII-PUB9T8T355
SaveCream
Lentaron Depot
Formestane, solid
NCGC00015070-04
NCGC00164380-02
Lentaron (TN)
Lentaron(R)17-dione
FORMESTANE [MI]
Opera_ID_865
FORMESTANE [MART.]
FORMESTANE [WHO-DD]
SCHEMBL25717
MLS001148070
Androst-4-ene-3, 4-hydroxy-
4-hydroxy-Delta4-androstenedione
BDBM225704
CS333
HMS2090I22
HMS2234J06
HMS3715G16
BCP03066
HY-B0697
Tox21_112111
Tox21_113509
Tox21_302286
MFCD00057814
NSC282175
s2208
4-hydroxy-androst-4-ene-3,17-dione
AKOS015895451
Tox21_112111_1
CCG-221077
DB08905
FF23546
NCGC00164380-01
NCGC00255321-01
NCGC00344560-01
AS-75658
NCI60_002316
NS00009015
D07260
AB00572625-07
A831133
SR-01000721948
Q3077501
SR-01000721948-2
4-Hydroxyandrost-4-ene-3,17-dione, 4-OHA, CGP-32349, lentaron;NSC 282175
(10R,13S)-4,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
(8R,9S,10R,13S,14S)-10,13-dimethyl-4-oxidanyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone
Solubility of (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
The solubility of (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione is influenced by its complex structure and functional groups. This compound exhibits a variety of solubility characteristics based on its molecular interactions.
Key factors affecting its solubility include:
To summarize, the solubility of this compound is likely to be low to moderate in water, while it may exhibit higher solubility in organic solvents with suitable polarity. This dual behavior indicates that while some functional groups allow for interaction with polar solvents, its overall hydrophobic characteristics may limit its solubility.
Understanding solubility is crucial for applications ranging from drug formulation to chemical synthesis.