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cortisol

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
(8R,9S,10R,13S,14S,16R,17S)-17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State
At room temperature, cortisol is a solid crystalline substance.
Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
580.00
Boiling point (Kelvin)
853.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.3100g/cm3
Appearence
Cortisol appears as a white to off-white crystalline powder.
Comment on solubility

Solubility of (8R,9S,10R,13S,14S,16R,17S)-17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of this complex organic compound is an intricate topic due to its unique molecular structure. **Understanding its solubility is central** for applications in pharmaceuticals and organic chemistry.

Key Factors Influencing Solubility:

  • Molecular Polarity: The presence of hydroxyl groups (–OH) increases polarity, which typically enhances solubility in polar solvents such as water.
  • Hydrophobic Regions: The cyclic structure and hydrophobic carbon chains can reduce solubility in water, promoting solubility in organic solvents like ethanol or acetone.
  • Temperature Effects: Increased temperature generally increases solubility due to enhanced molecular movement.
  • pH Levels: The solubility may also fluctuate with pH; for instance, at acidic or basic conditions, the compound could become ionized, influencing its interactions with solvents.

In conclusion, while aspects of its structure suggest a possibility for **moderate solubility in organic solvents**, it may exhibit limited solubility in aqueous solutions due to both hydrophobic characteristics and steric hindrance. This leads to a **intriguing balance** between polar and non-polar groups influencing its overall solubility profile.

Interesting facts

Exploring the Unique Compound: 17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This remarkable chemical compound embodies a complex structure that piques the interest of chemists and biochemists alike. Here are some fascinating aspects of this compound:

  • Stereochemistry: The compound's stereochemistry is intricate, indicated by its specific configurations (8R, 9S, 10R, 13S, 14S, 16R, 17S). Such configurations often play a critical role in how the compound interacts with biological systems, making it essential for understanding its potential applications.
  • Biological Relevance: Compounds similar to this one can exhibit significant biological activity. Many are found in nature and are vital to various biochemical pathways, including hormone regulation and signaling.
  • Potential Applications: Given its complex structure, this compound may have intriguing applications in pharmacology. The modification of its functional groups could lead to the development of new therapeutic agents targeted at specific diseases.
  • Research Opportunities: The synthesis and characterization of this compound may provide insights into advanced organic synthesis techniques. Chemists are often fascinated by the methodologies required to assemble such intricate molecules, making it a prime subject for research and study.
  • Natural Products Chemistry: This compound bears resemblance to natural products found in various plants and fungi, which have historically been sources of inspiration for drug development. Studying analogs can aid in discovering new drug candidates with improved properties.

In summary, the compound 17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one provides a fascinating window into the complexity of organic molecules and their vast potential in scientific research.

Synonyms
ALGESTONE
Alphasone
595-77-7
16alpha,17-Dihydroxypregn-4-ene-3,20-dione
Algestone [INN]
Algestona
Algestonum
Algestonum [INN-Latin]
Algestona [INN-Spanish]
CHEBI:763
UNII-3JEB53B3WT
EINECS 209-869-2
3JEB53B3WT
16alpha,17-Dihydroxy-4-pregnen-3,20-dion
ALGESTONE [MI]
ALGESTONE [WHO-DD]
DTXSID40208200
Pregn-4-ene-3,20-dione, 16,17-dihydroxy-, (16alpha)-
Algestonum (INN-Latin)
16.ALPHA.,17-DIHYDROXYPROGESTERONE
Algestona (INN-Spanish)
16.ALPHA.,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE
4-PREGNENE-16.ALPHA.,17.ALPHA.-DIOL-3,20-DIONE
(16.ALPHA.)-16,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE
(16alpha)-16,17-dihydroxypregn-4-ene-3,20-dione
DTXCID20130691
16 alpha,17 alpha-dihydroxyprogesterone
16ALPHA,17-DIHYDROXYPROGESTERONE
16 alpha,17-Dihydroxypregn-4-ene-3,20-dione
4-PREGNENE-16ALPHA,17ALPHA-DIOL-3,20-DIONE
209-869-2
dihydroxyprogesterone
CHEMBL2311120
Alfasone; Alphasone
SCHEMBL26178
(8R,9S,10R,13S,14S,16R,17S)-17-acetyl-16,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CXDWHYOBSJTRJU-SRWWVFQWSA-N
BDBM50474602
LMST02030171
16alpha,17alpha-dihydroxyprogesterone
AKOS025401436
AC-1645
FA17278
NS00010322
C06391
Q4724191
(16a)-16,17-Dihydroxy-pregn-4-ene-3,20-dione;16a,17-Dihydroxyprogesterone;4-Pregnen-16a,17a-diol-3,20-dione