Interesting facts
Interesting Facts about (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-tetrahydrofuran]-2',3-dione
This intriguing compound belongs to a class of natural products known for their complex structures and potent biological activities. It showcases a unique fusion of multiple cyclic frameworks, making it a subject of great interest in both synthetic and medicinal chemistry. Below are some fascinating aspects of this compound:
- Unique Structural Features: The compound exhibits a distinctive spiro-architecture, which contributes to its potential as a lead compound in drug discovery. Such structural complexity often correlates with a wide range of biological activities.
- Biological Relevance: Compounds with similar structures have been studied for their possible roles in anti-cancer, anti-inflammatory, and neuroprotective properties. This compound's functionalities may warrant investigation in pharmacological studies.
- Synthesis Challenges: The multi-cyclic configuration coupled with several stereocenters presents a significant challenge in synthetic organic chemistry. Researchers often modify established synthetic routes to navigate these complexities, showcasing ingenuity in chemical synthesis.
- Potential Applications: Beyond medicinal uses, such complex molecules are also crucial in materials science. The interactions governed by their three-dimensional structures open avenues in designing novel materials with unique properties.
- Research Interest: Due to its remarkable structural attributes, this compound can serve as a template in the development of analogs that might target specific biological pathways more effectively.
In summary, the exploration of this compound is not just about its chemical properties, but it also encapsulates the vast potential that complex organic molecules hold for innovation in various scientific fields. As noted by chemists, "The road to discovery is paved with the understanding of complex structures." Each chemical inquiry enriches our comprehension of nature's sophisticated designs.
Synonyms
CANRENONE
976-71-6
Aldadiene
Phanurane
Canrenona
Luvion
Aldadiene (VAN)
Canrenonum
Canrenone [USAN:INN]
Canrenonum [INN-Latin]
Canrenona [INN-Spanish]
SC-9376
EINECS 213-554-5
Spironolactone metabolite m1
Canrenone (USAN)
NSC 261713
UNII-78O20X9J0U
BRN 0046602
DTXSID3045930
11614 R.P
78O20X9J0U
CANRENONE [INN]
CANRENONE [MI]
CANRENONE [USAN]
CANRENONE [MART.]
NSC-261713
CANRENONE [WHO-DD]
17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
DTXCID1025930
11614 R. P.
EC 213-554-5
17alpha-(2-Carboxyethyl)-17beta-hydroxyandrosta-4,6-dien-3-one lactone
5-17-11-00476 (Beilstein Handbook Reference)
20-Spiroxa-4,6-diene-3,21-dione
(1'S,2R,2'R,10'R,11'S,15'S)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-6',8'-diene-5,5'-dione
Canrenonum (INN-Latin)
Canrenona (INN-Spanish)
CANRENONE (MART.)
17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone
SPIRONOLACTONE IMPURITY F [EP IMPURITY]
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-
Canrenon
17b-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid
17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid g-lactone
17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid lactone
17a-(2-Carboxyethyl)-17b-hydroxyandrosta-4,6-dien-3-one lactone
3-(17b-Hydroxy-3-oxoandrosta-4,6-dien-17a-yl)propionic acid lactone
2R)-3,4-DIHYDRO-5H-SPIRO(ANDROST-4,6-DIENE-17,2-FURAN)-3,5-DIONE
3'-(3-Oxo-17b-hydroxyandrosta-4,6-dien-17a-yl)-propionic acid lactone
3-(17b-Hydroxy-3-oxoandrosta-4,6-dien-17a-yl)propionic acid g-lactone
3-(3-Oxo-17b-hydroxy-4,6-androstadien-17a-yl)propionic acid g-lactone
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone (17.alpha.)-
11614 R.P.
SPIRONOLACTONE IMPURITY F (EP IMPURITY)
17.alpha.-(2-Carboxyethyl)-17.beta.-hydroxyandrosta-4,6-dien-3-one lactone
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone, (17.alpha.)-
(1'S,2R,2'R,10'R,11'S,15'S)-2',15'-dimethylspiro(oxolane-2,14'-tetracyclo(8.7.0.0^(2,7).0^(11,15))heptadecane)-6',8'-diene-5,5'-dione
SC-9376Canrenone
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone, (17alpha)-
17-Hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid lactone
Spiro(17H-cyclopenta(a)phenanthrene-17,2'(5'H)-furan), pregna-4,6-diene-21-carboxylic acid deriv.
Spiro[17H-cyclopenta[a]phenanthrene-17,2'(5'H)-furan], pregna-4,6-diene-21-carboxylic acid deriv.
17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid lactone
17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (8CI)
213-554-5
ujvlddzctmkxjk-uhfffaoysa-n
MFCD00071735
(8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, g-lactone,(17a)-
(10R,13S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
CAS-976-71-6
SMR000539206
Aldadiene;SC9376;SC14266
NCGC00095148-01
(8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
Canrenone (Standard)
Canrenone - 95%
SCHEMBL19560
MLS001163777
MLS001304014
MLS001304154
Canrenone - Bio-X trade mark
Canrenone, >=97% (HPLC)
CHEMBL1463345
HY-B1438R
CHEBI:135445
HMS2090K21
HMS2870D16
HMS3715A05
BCP10925
HY-B1438
Tox21_111451
(17a)-17-Hydroxy-3-oxopregna-4
BBL010921
s5273
STK801874
AKOS005622473
Tox21_111451_1
6-diene-21-carboxylic acid ?-lactone
AC-1323
CCG-220962
DB12221
FC19670
NCGC00263479-01
NCGC00263479-02
NCGC00263479-06
AS-13160
BC300044
FC166171
CS-0013142
NS00010904
D03363
D95826
EN300-123063
AB00825212-04
AB00825212-06
SR-01000813823
Q5033475
SR-01000813823-2
Z1546624239
Canrenone, European Pharmacopoeia (EP) Reference Standard
3',4'-Dihydrospiro[androst-4,6-diene-17,2'(5'H)-furan]-3,5'-dione (Canrenone)
(1R,3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-2,3,3a,3b,7,8,9,9a,9b,10,11,11a-dodecahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione
(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic acid gamma-lactone;17a-2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one lacton e;Phanurane
(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic acid gamma-lactone;17a-2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one lactone
Solubility of (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-tetrahydrofuran]-2',3-dione
The solubility of (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-tetrahydrofuran]-2',3-dione can be characterized as follows:
In conclusion, understanding the solubility of this compound is essential for its application in various fields, including medicinal chemistry and material science. Future studies and assays could aid in identifying optimal solvents for this compound's integration into various formulations.