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Testosterone

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Identification
Molecular formula
C19H28O2
CAS number
58-22-0
IUPAC name
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

Testosterone at room temperature is a solid substance. It is stable under normal conditions but can degrade when exposed to extended heat or direct light.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
412.00
Boiling point (Kelvin)
685.15
General information
Molecular weight
288.42g/mol
Molar mass
288.4240g/mol
Density
1.0708g/cm3
Appearence

Testosterone is typically a white or slightly creamy white crystalline powder. Its purity and form affect the exact appearance, but it is generally consistent in its solid state. It is also odorless.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of complex organic compounds like (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one can be influenced by various factors. Understanding its solubility characteristics is crucial for its application in pharmaceuticals and other fields. Here are some key points:

  • Polarity: The presence of hydroxyl (-OH) and acetyl (-COCH3) functional groups can impart some degree of polarity to the molecule, potentially enhancing its solubility in polar solvents like water or alcohols.
  • Hydrophobic Regions: The bulky hydrophobic hydrocarbon segments may hinder solubility in water but can promote solubility in organic solvents such as ethanol or dichloromethane.
  • Hydrogen Bonding: The ability of the compound to engage in hydrogen bonding can also enhance its solubility in suitable solvents, particularly those capable of forming such interactions.
  • Temperature Effects: Solubility often increases with temperature; thus, the compound may show different solubility behavior under various thermal conditions.

It is essential to conduct empirical experiments to establish precise solubility data, as theoretical predictions may not always align perfectly with reality. Therefore, a thorough understanding of the compound's solubility profile is vital for its effective use and formulation.

Interesting facts

Interesting Facts About (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one

This compound, a steroid-derived substance, presents a fascinating combination of structure and potential applications in various fields including pharmacology and biochemistry. Here are some intriguing aspects:

  • Steroidal Framework: The compound belongs to a class of molecules that are structurally related to steroids, which are vital in biochemical processes including hormonal function.
  • Natural Occurrence: Steroid compounds like this one can be found in various plants and animals, playing crucial roles in metabolism and regulatory functions.
  • Biological Activity: The functional groups (acetyl and hydroxy) suggest potential biological activity, making it a subject of interest for drug development and therapeutic applications.
  • Stereochemistry: With multiple stereocenters, this compound exhibits chirality, which can affect its biological interactions. The specific stereochemical configuration may lead to diverse biological effects.

As stated by prominent chemists, “The shape of a molecule determines its function.” Thus, the intricate structure of this octahydro-cyclopenta compound may influence its binding affinity to biological targets.

Researchers continue to investigate similar compounds for their potential in treating diseases, especially in the realms of cancer and hormonal therapies, reflecting the ongoing importance of natural products in developing innovative pharmaceutical solutions.

Synonyms
megestrol
3562-63-8
Megestrolo
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
Chronopil
Megestrolum
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
Megestrolum [INN-Latin]
HSDB 3233
UNII-EA6LD1M70M
EINECS 222-628-6
EA6LD1M70M
CHEBI:6722
DTXSID001009330
Megestrolum (INN-Latin)
Compound 5071
G03AC05
G03DB02
L02AB01
DTXCID001436159
222-628-6
Megestrol (INN)
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
MEGESTROL [INN]
Megestrol [INN:BAN]
Megestrol (Acetate)
Chronopil (TN)
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione; Megestrol; 6-Methyl-17-hydroxypregna-4,6-diene-3,20-dione
Megestrol (Standard)
MEGESTROL [HSDB]
MEGESTROL [VANDF]
MEGESTROL [WHO-DD]
SCHEMBL8942
GTPL9128
CHEMBL4071215
HY-B1834R
VXIMPSPISRVBPZ-NWUMPJBXSA-N
HY-B1834
s5738
FH39644
AC-32473
MS-25250
CS-0013903
NS00014345
C07120
D08167
MEGESTROL ACETATE IMPURITY B [EP IMPURITY]
Q410513