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Norethisterone acetate

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Identification
Molecular formula
C22H28O3
CAS number
51-98-9
IUPAC name
[(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
State
State

At room temperature, norethisterone acetate is in solid form.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
381.93
Boiling point (Kelvin)
655.08
General information
Molecular weight
340.47g/mol
Molar mass
340.4680g/mol
Density
1.1200g/cm3
Appearence

Norethisterone acetate is a white to off-white crystalline powder. It may appear as fine crystals or a solid mass.

Comment on solubility

Solubility of [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate

The solubility of the compound with the formula C22H28O3 can be explored through various criteria. Here are some insights regarding its solubility characteristics:

  • Polarity: The presence of carbonyl (C=O) and ether (–O–) functional groups often enhances solubility in polar solvents.
  • Hydrophobicity: With a relatively large hydrocarbon backbone, this compound may exhibit hydrophobic properties, leading to limited solubility in water.
  • Common Solvents: It is likely to be more soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO), which are compatible due to similar polarity characteristics.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, potentially enabling further dissolution in suitable solvents at elevated temperatures.

When testing for solubility, consider solubility parameters such as temperature, pressure, and solvent choice as they can greatly influence the behavior of the compound in various environments.

Understanding the solubility characteristics of this compound can aid researchers in determining the best conditions for its use in chemical applications.

Interesting facts

Interesting Facts about [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate

This compound, often referred to in the realm of synthetic organic chemistry, showcases the intricate beauty of molecular architecture. With its unique arrangement of atoms and stereochemical configurations, it serves multiple purposes in both research and application.

Key Highlights:

  • Stereochemistry: The specific stereochemistry (8R, 9S, etc.) indicates the compound's potential bioactivity. Stereochemical configuration is crucial in medicinal chemistry, as it can dramatically influence the biological activity of the compound.
  • Applications: Compounds like this one are often explored in the development of pharmaceuticals, particularly in the fields of hormones and steroids, highlighting their significance in medical applications.
  • Synthetic Pathways: The synthesis of such complex molecules often involves multiple steps and advanced techniques, making it a subject of interest for organic chemists.
  • Natural Analogues: Similar structural compounds are often found in nature; studying them can lend insight into biological processes and lead to new drug discoveries.

In the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” This compound exemplifies that sentiment as researchers continually seek to understand and harness its properties for innovation.

Overall, [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate is a testament to the complexity and potential of organic chemistry, inviting further exploration and possibilities.

Synonyms
Norethindrone acetate
Norethisterone acetate
19-Norethindrone acetate
51-98-9
Norlutin acetate
Orlutate
Norethisteron acetate
ENTA
Aygestin
Norlutate
Primolut-Nor
19-Norethisterone acetate
Gestakadin
Milligynon
Miniphase
Progylut
Milli-Anovlar
Norethysterone acetate
Norlutin A
Norlutine acetate
Norethindrone 17-acetate
19-Norethynyltestosterone acetate
Norethynyltestosterone acetate
Norethynyltestosterone
17alpha-Ethynyl-19-nortestosterone acetate
CCRIS 485
SH 420
(17-alpha)-Norethindrone acetate
UNII-9S44LIC7OJ
EINECS 200-132-0
9S44LIC7OJ
Norethindrone acetate [USP]
NSC 22844
NSC-22844
Norethisteroni acetas
17-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
BRN 2064104
CHEBI:7628
DTXSID4023381
17-alpha-Ethinyl-19-nortestosterone acetate
17-alpha-Ethynyl-19-nortestosterone acetate
17alpha-Ethynyl-17beta-acetoxy-19-norandrost-4-en-3-one
17beta-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
SH-420
Norethisterone 17-acetate
17beta-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
17alpha-Ethinyl-19-nortestosterone 17beta-acetate
17alpha-Ethinyl-19-nortestosterone-17beta-acetate
17alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate
Norethindrone acetate (USP)
17-alpha-Ethinyl-19-nortestosterone-17-beta-acetate
17-alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate
17-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
17-Acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
DTXCID601071
[(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
17-Hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one acetate
17-Acetyloxy(17-alpha)-19-norpregn-4-estren-17-beta-ol-acetate-3-one
Monogest
FEMHRT COMPONENT NORETHINDRONE ACETATE
17.alpha.-Ethynyl-19-nortestosterone acetate
ORIAHNN COMPONENT NORETHINDRONE ACETATE
ACTIVELLA COMPONENT NORETHINDRONE ACETATE
COMBIPATCH COMPONENT NORETHINDRONE ACETATE
MYFEMBREE COMPONENT NORETHINDRONE ACETATE
ESTROSTEP FE COMPONENT NORETHINDRONE ACETATE
Norethisterone acetate (JAN)
LO LOESTRIN FE COMPONENT NORETHINDRONE ACETATE
TRI-LEGEST FE COMPONENT NORETHINDRONE ACETATE
(17beta)-17-ethynyl-3-oxoestr-4-en-17-yl acetate
Norlutin-A
NORETHISTERONE ACETATE [JAN]
NORETHINDRONE ACETATE (USP-RS)
NORETHINDRONE ACETATE [USP-RS]
NORETHISTERONE ACETATE (MART.)
NORETHISTERONE ACETATE [MART.]
Ethinyl-nortestosterone acetate
NORETHINDRONE ACETATE (USP MONOGRAPH)
NORETHINDRONE ACETATE [USP MONOGRAPH]
NORETHISTERONE ACETATE (EP MONOGRAPH)
NORETHISTERONE ACETATE [EP MONOGRAPH]
SH-420C
Ortho Micronor
19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17.alpha.)-
NCGC00183366-01
Aygestin (TN)
norethindrone-acetate
17.alpha.-Ethinyl-19-nortestosterone acetate
19-nor-17alpha-Pregn-4-en-20-yn-3-one, 17-acetoxy-
Estr-4-en-3-one, 17alpha-ethynyl-17-hydroxy-, acetate
(17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one
17-alpha-Ethynyl-17-beta-acetoxy-19-norandrost-4-en-3-one
19-Nor-17alpha-ethynyltestosterone Acetate
Norethisterone acetate (Norethindrone acetate)
17-Acetoxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one
17.alpha.-Ethinyl-19-nortestosterone 17.beta.-acetate
19-nor-17.alpha.-Pregn-4-en-20-yn-3-one, 17-acetoxy-
SCHEMBL37530
17-Hydroxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one acetate
17.beta.-Acetoxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one
17-Acetyloxy(17.alpha.)-19-norpregn-4-estren-17.beta.-ol-acetate-3-one
17.beta.-Hydroxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one acetate
CHEMBL1201146
Norethindrone acetate (Standard)
HY-B1710R
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-acetoxy-
HMS3259A16
NORETHINDRONE ACETATE [MI]
19-Nor-17alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-, acetate
19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17alpha)
BCP11908
HY-B1710
NSC22844
Tox21_113371
NORETHINDRONE ACETATE [VANDF]
s5785
AKOS016010517
CS-7730
FN26444
NC00575
NORETHISTERONE ACETATE [WHO-DD]
NORETHISTERONE ACETATE [WHO-IP]
CAS-51-98-9
NCGC00159500-02
NCGC00183366-07
(1S,11S,15S,2R,10R,14R)-14-ethynyl-15-methyl-5-oxotetracyclo[8.7.0.0<2,7>.0<11 ,15>]heptadec-6-en-14-yl acetate
AS-13383
CPD001906776
NORETHINDRONE ACETATE [ORANGE BOOK]
17a-Ethynyl-19-nortestosterone 17b-acetate
FEMLYV COMPONENT NORETHINDRONE ACETATE
N0450
NORETHISTERONI ACETAS [WHO-IP LATIN]
C08152
D00953
T72561
NORETHINDRONE ACETATE COMPONENT OF FEMHRT
NORETHINDRONE ACETATE COMPONENT OF ORIAHNN
NORETHINDRONE ACETATE COMPONENT OF ACTIVELLA
NORETHINDRONE ACETATE COMPONENT OF MYFEMBREE
NORETHINDRONE ACETATE COMPONENT OF COMBIPATCH
17.alpha.-Ethynyl-17-hydroxyestr-4-en-3-one acetate
19-Nor-17.alpha.-pregn-4-en-20-yn-3-one, acetate
BRD-K96037667-001-01-4
NORETHINDRONE ACETATE COMPONENT OF ESTROSTEP FE
Q47495694
17.alpha.-Ethinyl-19-nortestosterone-17.beta.-acetate
NORETHINDRONE ACETATE COMPONENT OF LO LOESTRIN FE
NORETHINDRONE ACETATE COMPONENT OF TRI-LEGEST FE
WLN: L E5 B666 OV MUTJ E FOV1 F1UU1 -B&EF
(17alpha)-3-oxo-19-norpregn-4-en-20-yn-17-yl acetate
17.alpha.-Ethynyl-17.beta.-acetoxy-19-norandrost-4-en-3-one
19-Norethindrone acetate, VETRANAL(TM), analytical standard
Norethindrone acetate, United States Pharmacopeia (USP) Reference Standard
Norethisterone acetate, European Pharmacopoeia (EP) Reference Standard
Norethisterone acetate for system suitability, European Pharmacopoeia (EP) Reference Standard
(17?)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one;17?-Ethynyl-19-nortestosterone acetate
200-132-0