Skip to main content

Estradiol

ADVERTISEMENT
Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
State
State

Estradiol is typically a solid at room temperature, appearing as a white crystalline powder. It is a form of estrogen, a sex hormone, found in both men and women, and is one of the primary female sex hormones.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.00
Boiling point (Celsius)
458.40
Boiling point (Kelvin)
731.60
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.1650g/cm3
Appearence

Estradiol is a white, crystalline compound or appears as a white to almost white powder. It is practically insoluble in water and soluble in organic solvents such as alcohol, chloroform, and dioxane.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

The solubility of (8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol is a topic of interest due to the compound's unique structural characteristics. Understanding its solubility can provide insight into its potential applications and interactions with other substances.

Factors Influencing Solubility:

  • Polarity: Being a complex organic compound, its solubility may depend on its polarity. Compounds that possess functional groups capable of hydrogen bonding generally exhibit higher solubility in polar solvents.
  • Hydrophobicity: The presence of long hydrocarbon chains can lead to a hydrophobic character, potentially decreasing solubility in water but increasing it in non-polar organic solvents.
  • Temperature: Solubility can also vary with temperature changes; often, an increase in temperature results in enhanced solubility for solid compounds.

In general, it is often stated that "like dissolves like." Thus, the structural makeup of this compound likely leads to:

  • Limited solubility in polar solvents such as water.
  • Higher solubility in organic solvents, particularly non-polar ones.

Therefore, while the solubility profile of this compound can be complex, it can typically be expected to favor non-polar environments, reflecting its hydrophobic nature. Further experimental data would be necessary to determine exact solubility limits and to explore its behavior in various solvent systems.

Interesting facts

Interesting Facts about (8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

This complex organic molecule belongs to a class of compounds known for their intricate structures and biological significance. Here are some engaging points about this fascinating compound:

  • Stereochemistry: The unique stereochemistry indicated by its configuration shows the presence of multiple chiral centers, which plays a crucial role in determining the biological activity and properties of this compound.
  • Natural Occurrence: Compounds similar to this one are often found in natural sources, particularly in certain plant species, where they may play a role in hormonal functions or defense mechanisms.
  • Pharmaceutical Potential: Given its structural characteristics, researchers explore its potential therapeutic properties, particularly in areas such as anti-inflammatory and anticancer research.
  • Synthetic Pathways: The synthesis of such complex molecules presents exciting challenges in organic chemistry. Various synthetic methods, including total synthesis and semi-synthesis, can lead to exploring new reaction mechanisms and techniques.

As noted by renowned chemist Robert J. H. Grubbs, "The beauty of organic synthesis lies in the complexity of molecules that we can create and their potential applications in health and technology." This compound exemplifies that idea, showcasing the intersection of structure and function that is a hallmark of chemical research.

Overall, the study of (8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol not only underscores the complexity inherent in organic molecules but also highlights the exciting possibilities for discovery in future scientific endeavors.

Synonyms
ethylestrenol
Orabolin
Duraboral
Durabolin-O
Ethyloestrenol
965-90-2
Etilestrenol
Neodurabolin
Maxibalin
Orgabolin
Orgaboral
Ethylestrenolum
Ethyloestrenolum
Etilestrenolo
19-Nor-17alpha-pregn-4-en-17beta-ol
17alpha-Ethylestr-4-en-17beta-ol
HSDB 3327
17alpha-Ethyl-17beta-hydroxy-4-estrene
19-Norpregn-4-en-17-ol, (17alpha)-
UNII-ADC79EK5Q8
EINECS 213-523-6
Etilestrenol [INN-Spanish]
ADC79EK5Q8
Estr-4-en-17beta-ol, 17-ethyl-
NSC 37726
Ethylestrenolum [INN-Latin]
(17-alpha)-19-Norpregn-4-en-17-ol
17beta-Hydroxy-17alpha-ethyl-19-nor-4-androstene
DTXSID6023024
CHEBI:31578
NSC-37726
19-Nor-17alpha-pregn-4-en-17-ol
(17alpha)-19-norpregn-4-en-17-ol
19-Nor-17-alpha-pregn-4-en-17-ol
DTXCID503024
ORG-483
19-Norpregn-4-en-17-ol, (17-alpha)-
Etilestrenol (INN-Spanish)
Ethylestrenolum (INN-Latin)
ETHYLESTRENOL (MART.)
ETHYLESTRENOL [MART.]
A14AB02
19-NORPREGN-4-EN-17-OL, (17alpha)
213-523-6
Maxibolin
Ethylnandrol
Ethylnandrol (JAN)
(8R,9S,10R,13S,14S,17S)-17-ethyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
NCGC00167514-01
ETHYLNANDROL [JAN]
Etilestrenolo [DCIT]
(17beta)-17-ethylestr-4-en-17-ol
CAS-965-90-2
SMR000238204
Ethylestrenol (1.0mg/ml in Acetonitrile)
Ethylestrenol [USAN:INN:BAN]
Orabolin (TN)
ETHYLESTRENOL [MI]
ETHYLESTRENOL [INN]
Ethylestrenol (USAN/INN)
ETHYLESTRENOL [HSDB]
ETHYLESTRENOL [USAN]
ETHYLESTRENOL [VANDF]
MLS000759411
MLS001424123
SCHEMBL147908
ETHYLESTRENOL [WHO-DD]
GTPL6948
CHEMBL1200623
AOXRBFRFYPMWLR-XGXHKTLJSA-N
HMS2051P08
ETHYLESTRENOL [ORANGE BOOK]
Tox21_112512
Tox21_112512_1
CCG-101014
DB01493
NC00264
NCGC00167514-02
NS00040493
D01414
17alpha-Ethylestr-4-en-17beta-ol; Ethylnandrol
Q764283
19-NORPREGN-4-EN-17-OL, (17.ALPHA.)
W-100138