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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, estrone is in a solid state. It is typically found as a powder or crystals and is stable under standard conditions of storage and handling.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.00
Boiling point (Celsius)
444.40
Boiling point (Kelvin)
717.60
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone is often found as a colorless to white crystalline powder when isolated in its pure form. It can appear as crystals or crystalline solid depending on the method of purification and storage.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

The solubility of (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one can be considered under various conditions:

  • Solvent Dependency: The solubility of this compound is highly dependent on the solvent used. Generally, organic solvents such as ethanol, methanol, and DMSO are more effective at dissolving such complex organic compounds.
  • Temperature Influence: Like many organic compounds, an increase in temperature often enhances solubility. Elevated temperatures can help break intermolecular interactions, allowing for greater dissolution.
  • Polarity Considerations: As a largely hydrophobic molecule, it shows low solubility in polar solvents like water. This characteristic is common among steroid-like structures due to their lipophilic natures.

Furthermore, to illustrate:

"The degree of solubility is not only critical for practical applications in pharmaceuticals and chemical synthesis, but also influences the bioavailability and pharmacokinetics of the compound."

In conclusion, understanding the solubility of (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one is essential for its effective use in various fields, particularly in medicinal chemistry where it can impact drug formulation and delivery strategies.

Interesting facts

Interesting Facts About 17-Hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

This fascinating compound is a member of the steroid family and showcases the complex nature of organic chemistry. Here are some engaging facts about this particular compound:

  • Stereochemistry: The stereochemical configuration of this molecule is particularly interesting, featuring multiple chiral centers. This gives rise to various stereoisomers, which can have distinct biological activities and properties.
  • Biological Relevance: Compounds similar to this one are often studied for their potential hormonal activities, making them relevant in pharmacology and medicinal chemistry.
  • Structure Complexity: The intricate arrangement of carbon rings within the structure presents unique challenges and opportunities for synthetic chemists, as they strive to replicate or modify the compound for better efficacy.
  • Natural Occurrence: Compounds with similar frameworks can be found in certain plants and animals, leading researchers to explore their natural sources for pharmaceutical applications.
  • Medicinal Applications: Investigations into this class of compounds reveal their potential in treating various conditions, including hormonal disorders and certain cancers.
  • Research Frontiers: Ongoing research is focused on understanding the mechanisms of action and efficacy of this compound in biological systems, which could pave the way for novel therapeutic agents.

As a scientist or chemistry student, engaging with such complex compounds not only enhances our knowledge of organic chemistry but also illuminates the profound connection between molecular structure and physiological function. The study of this compound exemplifies how deepening our understanding of chemistry can lead to **innovative solutions** in healthcare and biotechnology.

Synonyms
6-Dehydrotestosterone
2484-30-2
6,7-Dehydrotestosterone
6,7-didehydrotestosterone
delta(sup 6)-Testosterone
17beta-hydroxyandrosta-4,6-dien-3-one
NSC 75560
EINECS 219-623-6
Delta6-Testosterone
(17beta)-17-Hydroxyandrosta-4,6-dien-3-one
Androsta-4,6-dien-17-beta-ol-3-one
4P45K0O2LX
17-beta-Hydroxyandrosta-4,6-dien-3-one
Delta(6)-testosterone
NSC-75560
(17-beta)-17-Hydroxyandrosta-4,6-dien-3-one
UNII-4P45K0O2LX
.DELTA.6-TESTOSTERONE
CHEBI:29117
ANDROSTA-4,6-DIEN-3-ONE, 17-beta-HYDROXY-
17-hydroxy-4,6-androstadiene-3-one
Androsta-4,6-dien-3-one, 17-hydroxy-, (17-beta)-
Androsta-4,6-dien-3-one, 17-hydroxy-, (17beta)-
Androsta-4,6-dien-3-one, 17-hydroxy-, (17.beta.)-
TESTOSTERONE IMPURITY I [EP IMPURITY]
TESTOSTERONE IMPURITY I (EP IMPURITY)
17 beta-hydroxy-4,6-androstadien-3-one
17 beta-hydroxyandrosta-4,6-dien-3-one
(17 beta)-17-hydroxyandrosta-4,6-dien-3-one
Androsta-4,6-dien-3-one, 17-hydroxy-, (17beta)-(9CI)
Androsta-4,6-dien-3-one, 17-hydroxy-, (17-beta)-(9CI)
219-623-6
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
6-Dehydrotestosterone Acetate
2352-19-4
4,6-Androstadien-17.beta.-ol-3-one
SCHEMBL3364701
UMDCOKNNLDEKJB-DYKIIFRCSA-N
DTXSID801043247
NSC75560
LMST02020082
4,6-Androstadiene-17beta-ol-3-one
17b-hydroxy-4,6-androstadiene-3-one
FT28049
17-Hydroxyandrosta-4,6-dien-3-one #
17beta-Hydroxyandrost-4,6-dien-3-one
Androsta-4, 17-hydroxy-, (17.beta.)-
NS00046283
Q27109951
17?-Hydroxyandrosta-4,6-dien-3-one (?6-Testosterone)
17beta-Hydroxyandrosta-4,6-dien-3-one (?6-Testosterone)
(17b)-17-Hydroxy-Androsta-4,6-dien-3-one;Androst-4,6-dien-17?-ol-3-one;?6-Testosterone
(1S,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one