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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

Estrone is typically a solid at room temperature.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone appears as a white or creamy white, odorless crystalline powder.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of the compound with the chemical formula C18H22O2, commonly known as a steroidal compound, can be discussed from various perspectives:

  • Polarity: The presence of hydroxyl (-OH) groups contributes to the compound's polarity, making it more soluble in polar solvents compared to non-polar solvents.
  • Solvent Effects: This compound is likely to show good solubility in organic solvents such as ethanol or methanol due to its hydrophobic characteristics.
  • Temperature Influence: Generally, solubility can increase with temperature. Thus, higher temperatures may aid in dissolving this compound in suitable solvents.
  • pH Variations: The solubility can also be affected by the pH of the solution, especially since the hydroxyl group can engage in ionization under certain conditions.

In summary, while this compound is expected to demonstrate reasonable solubility in organic solvents, its exact solubility behavior will depend on a variety of factors including the solvent type and environmental conditions. Understanding these parameters is crucial for practical applications.

Interesting facts

Exploring the Compound: (8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This compound is a fascinating member of the steroid family, notable for its complex and stereospecific structure that contributes significantly to its biological activity. As you delve into the study of this compound, here are some intriguing aspects to consider:

  • Stereochemistry: This compound features multiple stereocenters, indicated by its detailed stereochemical descriptors (8R, 9S, 10R, etc.). Understanding the spatial arrangement of these atoms is crucial, as it often dictates the compound's behavior in biological systems.
  • Natural Occurrence: Compounds with similar structures can be found in various biological systems, where they may serve as hormones or signaling molecules, exemplifying the profound connection between chemistry and life.
  • Applications: The unique properties of this compound suggest potential applications in pharmaceuticals, particularly in areas involving hormonal regulation or therapeutic targets in treating specific diseases.
  • Mechanism of Action: Studying how such compounds interact with biological receptors can unravel mechanisms that are critical in medicinal chemistry, potentially leading to the development of new drugs.

As you continue your exploration of this compound, remember that every detail contributes to the bigger picture of how chemistry influences not only materials but also the very fabric of life itself. The intricate interplay between structure and function is what makes the study of compounds like this one both challenging and rewarding.

Synonyms
methyltestosterone
17-Methyltestosterone
58-18-4
Metandren
Android
Testred
Androsan
Androsten
Mesterone
Virilon
Dumogran
Masenone
Metestone
Malogen
Syndren
17alpha-Methyltestosterone
Oreton Methyl
Glosso-sterandryl
Neo-Hombreol-M
Malestrone
Mastestona
Synandrets
Synandrotabs
Andrometh
Anertan
Homandren
Hormale
Metrone
Nabolin
Oraviron
Steronyl
Testora
Orchisterone-M
Testovis Depot
Metiltestosterona
Oreton-M
M.T.Mucorettes
Nu-man
Android 5
NSC-9701
Homandren, tablets
Android 10
Android 25
Estratest
Methitest
Methyltestosteronum
Testovis (tablet)
17beta-Hydroxy-17-methylandrost-4-en-3-one
Oretron
Metiltestosterone
CDB 110
RU 24400
17-Methyltestosteron
Methyltestosterone ciii
17-Hydroxy-17-methyl-3-keto-androstene-4
CCRIS 3723
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
4-Androstene-17alpha-methyl-17beta-ol-3-one
17-beta-Hydroxy-17-methylandrost-4-en-3-one
HSDB 3365
UNII-V9EFU16ZIF
Anertan, tablets
V9EFU16ZIF
L 589.372
EINECS 200-366-3
17.alpha.-Methyltestosterone
U 2842
NSC 139965
NSC-139965
17alpha-Methyl-delta-androsten-17beta-ol-3-one
BRN 2057425
DTXSID1033664
Methyltestosteronum [INN-Latin]
Metiltestosterona [INN-Spanish]
CHEBI:27436
CDB-110
17|A-Methyltestosterone
METHYL TESTOSTERONE
Androst-4-en-3-one, 17beta-hydroxy-17-methyl-
(17-beta)-17-Hydroxy-17-methylandrost-4-en-3-one
RU-24400
17(alpha)-Methyl-delta4-androsten-17(beta)-ol-3-one
DTXCID9013664
Oreton M
Androsan, tablets
NSC9701
U-2842
component of Estan
17-MT
4-08-00-01010 (Beilstein Handbook Reference)
(17beta)-17-hydroxy-17-methylandrost-4-en-3-one
L-589372
Neo-Hombreol [M]
L-589.372
Neo-Homobreol (M)
Neo-Homobreol [M]
component of Gynetone
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Methyltestosterone [USP:INN:BAN:JAN]
NCGC00091009-03
Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17.beta.)-
component of Tylosterone
17a-methyl testosterone
Glosso sterandryl
Testosterone, 17-methyl-
17alpha-methyl-Delta4-androsten-17beta-ol-3-one
Anertan (tablets)
Homandren (VAN)
17.alpha.-Methyl-3-oxo-4-androsten-17.beta.-ol
Androsan (tablets)
Androsan (VAN)
Testoviron (VAN)
Anertan (VAN)
17alpha-methyl-Delta(4)-androsten-17beta-ol-3-one
4-Androstene-17.alpha.-methyl-17.beta.-ol-3-one
Androst-4-en-3-one, 17.beta.-hydroxy-17-methyl-
Testoviron (tablet)
Methyltestosteronum (INN-Latin)
Metiltestosterona (INN-Spanish)
17(alpha)-methyl-Delta(4)-androsten-17(beta)-ol-3-one
METHYLTESTOSTERONE (MART.)
METHYLTESTOSTERONE [MART.]
METHYLTESTOSTERONE (USP-RS)
METHYLTESTOSTERONE [USP-RS]
17beta-Methyltestosterone
Estan (Salt/Mix)
Metiltestosterone [DCIT]
17 beta-Methyltestosterone
CAS-58-18-4
Methyltestosterone (USP:INN:BAN:JAN)
Estratest (Salt/Mix)
METHYLTESTOSTERONE (EP MONOGRAPH)
METHYLTESTOSTERONE [EP MONOGRAPH]
METHYLTESTOSTERONE (USP MONOGRAPH)
METHYLTESTOSTERONE [USP MONOGRAPH]
SMR000058528
Android (TN)
17 Epimethyltestosterone
17?-Methyl Testosterone (1.0 mg/mL in Methanol)
17beta Methyltestosterone
WLN: L E5 B666 OV MUTJ A E FQ F -B&AEF
17 beta Methyltestosterone
17-alpha-Methyltestosterone
component of Gynetone (Salt/Mix)
Testomet
Testovis
Eldec
Neohombreol M
Premarin with methyltestosterone
Testotonic B
17beta-Hydroxy-17-methyl-4-androsten-3-one
Ero Test
17 beta-Hydroxy-17-methyl-4-androsten-3-one
4-Androstene-17-alpha-methyl-17-beta-ol-3-one
NCGC00091009-04
NCGC00091009-05
Testred (TN)
Premarin with Methyltestosterone (Salt/Mix)
TESTHORMONA
17-Hydroxy-17-methylandrost-4-en-3-one #
Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17b)-
MT MUCORETTES
17a-methyltestosterone
17-.beta.-Hydroxy-17-methylandrost-4-en-3-one
Androst-4-en-3-on-17.beta.-ol, 17.alpha.-methyl
Methyltestosterone solution
Androst-4-ene-17.alpha.-methyl-17.beta.-ol-3-one
17beta Hydroxy 17 methyl 4 androsten 3 one
17 beta Hydroxy 17 methyl 4 androsten 3 one
17.beta.-Hydroxy-17.alpha.-methylandrost-4-en-3-one
17.alpha.-methyl-.DELTA.4-androsten-17.beta.-ol-3-one
CHEMBL1395
SCHEMBL18657
Androst-4-en-3-one, 17-beta-hydroxy-17-methyl-
MLS000759474
MLS001424040
MLS002174282
GTPL6945
METHYLTESTOSTERONE [INN]
METHYLTESTOSTERONE [JAN]
METHYLTESTOSTERONE [HSDB]
.ALPHA.-METHYLTESTOSTERONE
G03BA02
G03EK01
METHYLTESTOSTERONE [VANDF]
HMS2051A14
HMS2272A06
METHYLTESTOSTERONE [WHO-DD]
METHYLTESTOSTERONE [WHO-IP]
(1S,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
17-METHYLTESTOSTERONE [MI]
HY-A0121
Tox21_113161
Tox21_113162
Tox21_400058
BDBM50410531
LMST02020029
Methyltestosterone (JP17/USP/INN)
MSK2221-100A
NSC139965
AKOS015917317
Tox21_113162_1
CCG-100871
CS-5099
DB06710
GS-6594
NC00121
METHYLTESTOSTERONE [ORANGE BOOK]
NCGC00091009-01
NCGC00091009-06
NCGC00091009-07
Oxandrolone impurity, methyltestosterone-
FM112033
METHYLTESTOSTERONUM [WHO-IP LATIN]
SMR001261452
M0435
NS00010270
17alpha-Methyltestosterone, >=97.0% (HPLC)
17Alpha-Methyltestosterone, 1mg/ml in Methanol
C07198
D00408
Methyltestosterone (17alpha-Methyltestosterone)
AB00443683-06
AB00443683-09
17alpha-Methyltestosterone, solid (photosensitive)
17beta-Hydroxy-17alpha-methylandrost-4-en-3-one
Q421768
17 Alpha-methyl-delta4-androsten-17beta-ol-4-one
BRD-K84036904-001-08-8
Methyltestosterone Solution in Acetonitrile, 100ug/mL
17BETA-17-HYDROXY-17-METHYLANDROST-4-EN-3-ONE
17-alpha-Methyltestosterone 100 microg/mL in Acetonitrile
17alpha-Methyltestosterone, VETRANAL(TM), analytical standard
OXANDROLONE IMPURITY, METHYLTESTOSTERONE- [USP IMPURITY]
OXANDROLONE IMPURITY, METHYLTESTOSTERONE-(USP IMPURITY)
Methyltestosterone, European Pharmacopoeia (EP) Reference Standard
Methyltestosterone (17alpha-Methyltestosterone) 1.0 mg/ml in Acetonitrile
Methyltestosterone, United States Pharmacopeia (USP) Reference Standard
Methyltestosterone for system suitability, European Pharmacopoeia (EP) Reference Standard
(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
(8R,10R,13S,17S)-17-Hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
200-366-3