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Estrone sulfate

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Identification
Molecular formula
C18H22O5S
CAS number
2956-04-1
IUPAC name
[(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
State
State

At room temperature, estrone sulfate is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
572.00
Boiling point (Kelvin)
845.15
General information
Molecular weight
350.47g/mol
Molar mass
350.4730g/mol
Density
1.3400g/cm3
Appearence

Estrone sulfate is typically a white to off-white crystalline powder. It may appear slightly yellow if impurities are present.

Comment on solubility

Solubility of [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate

The solubility of a compound is a crucial property that influences its behavior in various environments and applications. In the case of [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate, we can delve deeper into the factors affecting its solubility:

  • Polarity: The presence of the hydrogen sulfate group (–OSO3H) indicates that this compound has polar characteristics, which typically enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group (–OH) contributes to the ability of the molecule to form hydrogen bonds with water molecules, further increasing solubility.
  • Temperature Dependency: Generally, solubility can be temperature-dependent. Higher temperatures may enhance solubility due to increased molecular movement and disruption of solute-solvent interactions.
  • pH Sensitivity: The solubility of and reactivity of the hydrogen sulfate group can also vary with pH, affecting its overall solubility in different environments.

In conclusion, the solubility of [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate is likely to be considerable in polar solvents. However, specific experimental data would be necessary to quantify this solubility precisely, as various factors can alter it significantly. As the renowned chemist Linus Pauling once said, “The best way to have a good idea is to have a lot of ideas,” indicating the importance of extensive research and exploration in understanding solubility characteristics.

Interesting facts

Interesting Facts about [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate

As a complex organic compound, [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate presents a fascinating area of study within the field of organic chemistry. This compound belongs to an intriguing class of steroidal structures characterized by their multi-ring systems and specific stereochemistry. Here are some interesting aspects:

  • Steroidal Framework: Its structure is reminiscent of steroids, with unique cyclic components that contribute to its biological activity.
  • Hydroxyl Group: The presence of a hydroxyl group (-OH) significantly contributes to the compound's reactivity and may influence its interaction with biological systems.
  • Hydrogen Sulfate Component: The incorporation of the hydrogen sulfate moiety highlights its potential role as a sulfate ester, suggesting possible applications in biochemical syntheses or as an intermediate in various reactions.
  • Stereochemistry: The specified stereocenters (8R, 9S, 13S) are crucial, as they can greatly affect the compound's pharmacological properties and biological interactions, which bear implications in medicinal chemistry.
  • Biological Significance: Compounds with similar structures are often investigated for their performance in drug design, particularly in the field of hormone replacement therapy and cancer research.

In summary, the complexity and multifaceted nature of [(8R,9S,13S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate make it an intriguing subject for chemists and biologists alike. Its unique properties not only spark curiosity about its synthesis and reactivity but also shed light on its potential applications in pharmaceuticals and other fields.