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Ethynyl estradiol

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Identification
Molecular formula
C20H24O2
CAS number
57-63-6
IUPAC name
(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
State
State

At room temperature, ethynyl estradiol exists as a solid. It is typically handled as a fine powder.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
618.00
Boiling point (Kelvin)
891.15
General information
Molecular weight
296.40g/mol
Molar mass
296.4040g/mol
Density
1.2273g/cm3
Appearence

Ethynyl estradiol is a white to creamy white crystalline powder.

Comment on solubility

Solubility of (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

The solubility of (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol is an important characteristic that influences its behavior in various chemical environments. It is generally classified as a lipophilic compound due to its complex hydrocarbon structure, which may lead to limited solubility in water. Here are some key points to consider regarding its solubility:

  • Water Solubility: This compound is expected to have low solubility in aqueous solutions due to its hydrophobic nature.
  • Organic Solvents: It is likely to be more soluble in organic solvents (such as ethanol, acetone, or chloroform) due to similar non-polar characteristics.
  • Effect of Temperature: Solubility may increase with temperature in organic solvents, leading to improved dissolution rates.
  • Interaction with Other Compounds: The solubility may also be affected by the presence of other solutes, which could either increase or decrease solubilization through various interactions.

In summary, the solubility of this compound is primarily influenced by its molecular structure and the polarity of the solvent used. As always, performing solubility tests under specific conditions will yield the most accurate and relevant information for practical applications.

Interesting facts

Interesting Facts about (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol

This compound, a complex steroid-like substance, stands out due to its intricate structure and its relevance in biochemical research. Here are some fascinating aspects:

  • Stereochemistry: This compound exhibits distinctive stereochemical configurations, denoted by its multiple stereocenters. The presence of stereocenters not only influences its physical properties but also its biological activity.
  • Applications: Due to its structural similarity to natural hormones, this compound is often studied for its potential applications in pharmacology, particularly in hormonal therapies and treatments concerning reproductive health.
  • Natural Occurrence: Compounds of this nature and structural complexity can often be analogs of endogenous steroids found in many species, making them significant for comparative biological studies.
  • Mechanism of Action: Research indicates that the compound may interact with hormone receptors, which can lead to modulation of gene expression and influence various physiological processes.
  • Research Interest: The scientific community is increasingly interested in the pharmacodynamics of this compound, making it a valuable subject for ongoing research concerning synthetic pathways and biological interactions.

As you delve deeper into the world of this compound, remember the words of the famous chemist Linus Pauling: "The best way to have a good idea is to have lots of ideas." Studying compounds like this one can inspire new ideas and innovations in the field of chemistry and medicine.


Overall, the complexity and potential applications of (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol make it an intriguing compound worthy of exploration.

Synonyms
TIGESTOL
896-71-9
Tigestol [USAN:INN]
UNII-1WAE0P123G
1WAE0P123G
19-Nor-17alpha-pregn-5(10)-en-20-yn-17-ol
19-Norpregn-5(10)-en-20-yn-17-ol, (17alpha)-
TIGESTOL [USAN]
Tigestol (USAN/INN)
TIGESTOL [INN]
SCHEMBL282405
CHEMBL2105440
19-Norpregn-5(10)-en-20-yn-17-ol, (17.alpha.)-
DTXSID501024751
(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
NS00120996
D06145
Q24897620