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Testosterone propionate

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Identification
Molecular formula
C22H32O3
CAS number
57-85-2
IUPAC name
[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] propanoate
State
State

At room temperature, testosterone propionate is a solid, typically in the form of a crystalline powder. It is not volatile and has a high melting point.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
457.10
Boiling point (Kelvin)
730.25
General information
Molecular weight
344.50g/mol
Molar mass
344.5010g/mol
Density
1.1205g/cm3
Appearence

Testosterone propionate is a white or off-white crystalline powder. It is practically insoluble in water, but soluble in organic solvents such as alcohol, chloroform, and dioxane.

Comment on solubility

Solubility Characteristics of the Compound

The solubility of the compound (8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl propanoate can be influenced by several key factors:

  • Polarity: Given that this compound contains a hydroxyl (–OH) group, it tends to exhibit polar characteristics. This may enhance its solubility in polar solvents, such as water.
  • Hydrophobic Regions: The presence of extensive hydrocarbon chains in its structure suggests that it also has considerable hydrophobic character, which can reduce its solubility in aqueous environments, favoring solubility in organic solvents.
  • Temperature: Solubility can vary with temperature. Generally, increasing temperature can enhance the solubility of many solid compounds in their respective solvents.
  • Concentration of Solvents: This compound may have better solubility in dilute solutions of organic solvents compared to concentrated solutions.

In conclusion, while the compound showcases both polar and nonpolar characteristics, leading to a complex solubility profile, the nature of the solvent plays a critical role in determining the extent to which it can dissolve. As such, it's important to consider both the solvent environment and the structural elements of the compound when predicting its solubility.

Interesting facts

Interesting Facts About 3-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl Propanoate

This compound, more commonly known as a derivative of the steroid family, exhibits unique structural features that contribute to its biological activity. Its complex stereochemistry is defined by multiple chiral centers, specifically at the 8R, 9S, 13S, 14S, and 17S positions, making it an intriguing subject for researchers studying chirality in pharmaceuticals.

Biological Significance

Compounds like this one are often investigated for their potential physiological effects. Here are some interesting aspects:

  • Hormonal Activity: Many compounds in this class can interact with hormone receptors, influencing various biological processes.
  • Anti-inflammatory Properties: Some derivatives are noted for their ability to modulate inflammation, making them potential candidates in therapeutic applications.
  • Metabolic Pathways: The compound may participate in or influence steroid metabolic pathways, contributing to its relevance in endocrinology.

Synthesis and Applications

The synthesis of such complex molecules involves intricate chemical reactions, requiring precise control over the reaction conditions to ensure stereoselectivity. Notably:

  • It may involve multi-step syntheses, utilizing various reactions such as hydroxylation, alkylation, and functional group transformations.
  • The final product can have important applications in drug design, particularly in developing therapies for hormone-related conditions.

As a compound with multiple implications in chemistry and medicine, the understanding of 3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl propanoate requires a multidisciplinary approach, bridging organic chemistry, biochemistry, and pharmacology. Its study continues to inspire new research aimed at uncovering its full potential in health sciences.

In summary, this compound stands as a testament to the complexities of organic synthesis and the profound impacts such molecules can have on human health.

Synonyms
3758-34-7
ESTRADIOL 17-PROPIONATE
estradiol propionate
beta-Estradiol 17-propionate
Estradiol17-Propionate
[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] propanoate
DTXSID4048985
K31PC34297
Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 17-propanoate
UNII-K31PC34297
NCGC00183033-01
(17beta)-Estra-1,3,5(10)-triene-3,17-diol 17-Propanoate; Estradiol 17-Propionate 17beta-Estradiol 17-Propionate; Akrofollin; Estradiol Propionate; Oestra-1,3,5(10)-trien-3,17beta-diol 17-Propionate;
EINECS 223-164-7
SCHEMBL480992
CHEMBL2356687
DTXCID4028911
Estra-1,3,5(10)-triene-3,17beta-diol 17-propionate
PQCRZWCSVWBYSC-AGRFSFNASA-N
(1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
Tox21_113447
FE22825
CAS-3758-34-7
NS00030219
Q27281883
1,3,5(10)-ESTRATRIENE-3,17.BETA.-DIOL 17-PROPIONATE
(17?)-Estra-1,3,5(10)-triene-3,17-diol 17-propanoate;Estradiol 17-propionate 17?-estradiol 17-propionate;Akrofollin