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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(8R,9S,13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
State
State
At room temperature, estradiol is typically in a solid state. It is often handled as its crystalline form or as a fine powder, which makes it suitable for incorporation into pharmaceutical formulations.
Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
458.50
Boiling point (Kelvin)
731.65
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1730g/cm3
Appearence

Estradiol is a white or colorless crystalline solid. It may also appear as a white or almost white crystalline powder. The compound is odorless or has a slight characteristic odor. It is known for its structural stability and purity when isolated as a pharmaceutical compound.

Comment on solubility

Solubility of (8R,9S,13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of organic compounds like (8R,9S,13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol can vary greatly based on several factors. Here are some key points to consider:

  • Polarity: This compound features multiple hydroxyl (–OH) groups, which can significantly influence its solubility in polar solvents such as water. Generally, the presence of these functional groups enhances the solubility of organic compounds in aqueous environments.
  • Hydrophobic Regions: The compound consists of a complex hydrocarbon structure that may contribute to hydrophobic interactions, potentially leading to reduced solubility in strongly polar solvents.
  • Solvent Choice: For practical solubility, this compound may perform better in organic solvents like alcohols or ethers due to its molecular structure, which supports solvent interactions outside of polar conditions.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature, so understanding the temperature-dependent behavior of this compound may be important for its applications.

In summary, while the hydroxyl groups suggest a potential for good solubility in polar solvents, the bulky hydrocarbon framework might limit solubility under certain conditions. Therefore, the overall solubility profile of this compound is multifaceted, influenced by environmental and structural factors.

Interesting facts

Interesting Facts About (8R,9S,13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

This compound, a complex polycyclic structure, has garnered attention in various fields, particularly in biochemistry and pharmacology. Its intricate configuration and stereochemistry contribute to some fascinating properties and potential applications.

Key Features

  • Steroidal Backbone: The compound's structure alludes to its relation to steroid frameworks, which is significant as steroids are crucial in many biological processes.
  • Biological Activity: Compounds like this one often exhibit bioactivity, potentially influencing hormonal pathways or serving therapeutic roles.
  • Stereochemistry Importance: The specific stereochemical configuration (8R, 9S, 13S, 17S) can dramatically impact the compound's interactions with biological receptors, determining its efficacy and safety in pharmaceutical applications.

Applications

The unique properties of this compound make it a candidate for research in areas such as:

  • Drug Discovery: With ongoing studies surrounding its pharmacological effects, the compound could lead to the development of new treatments.
  • Hormone Regulation: Insights into its interaction mechanism may help in designing agents that can modulate hormonal activities.
  • Biological Research: This compound serves as a useful tool for elucidating biological processes due to its complex structure reminiscent of natural hormones.

Conclusion

In summary, (8R,9S,13S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol exemplifies the rich intersection of chemistry and biology. As researchers continue to uncover its potential, we gleam insights into how such compounds can shape our understanding of biochemical pathways and opportunities for therapeutic interventions. The study of such compounds emphasizes the importance of molecular structure in defining the biological functions and interactions of materials.

Synonyms
SCHEMBL10039280