Skip to main content

Docetaxel

ADVERTISEMENT
Identification
Molecular formula
C43H53NO14
CAS number
114977-28-5
IUPAC name
[(8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State
Docetaxel is in a solid state at room temperature. It is usually formulated for medical use in an injectable form, often combined with a solvent to ensure proper delivery through intravenous administration.
Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
650.00
Boiling point (Kelvin)
923.15
General information
Molecular weight
807.88g/mol
Molar mass
807.8790g/mol
Density
1.4800g/cm3
Appearence
Docetaxel is a white to almost-white crystalline powder that is practically insoluble in water, but freely soluble in polar organic solvents such as ethanol and methanol. The compound has a distinct crystalline structure which is typical for many pharmaceutical active ingredients.
Comment on solubility

Solubility of [(8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of complex organic compounds such as [(8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate is often influenced by various factors:

  • Polarity: The presence of functional groups such as amino (-NH2) and methoxy (-OCH3) significantly affects solubility in polar and nonpolar solvents.
  • Hydrogen bonding: Compounds capable of forming hydrogen bonds tend to have increased solubility in water.
  • Molecular weight: Higher molecular weight can hinder solubility due to reduced mobility.
  • Temperature: Generally, solubility increases with temperature for solids.

Due to these factors, it is important to note that the solubility of this compound may be limited in aqueous solutions, as is common with many complex organic molecules. The intricate structure of this compound, characterized by multiple ring systems and functional groups, might lead to poor solubility in water while showing more favorable solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol.

In conclusion, the solubility of [(8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate requires careful consideration of its chemical structure and the environment in which it is placed.

Interesting facts

Exploring the Intricacies of [(8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The compound known as (8S)-11-amino-5-benzoyl-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-ylmethyl carbamate is a fascinating example of chemical complexity and potential applications in medicinal chemistry. Here are some compelling facts about this innovative compound:

  • Structural Diversity: This compound features a unique tetracyclic structure, showcasing the versatility of nitrogen-rich compounds in pharmaceutical design.
  • Functional Groups: The presence of multiple functional groups, such as the amino, benzoyl, and methoxy groups, indicates significant potential for biochemical interactions, highlighting its possible role as a bioactive molecule.
  • Potential Therapeutic Uses: Compounds with similar structural characteristics are often evaluated for their efficacy in treating various diseases, including cancer and infections.
  • Stereochemistry: The stereochemistry denoted by the (8S) configuration could influence the compound’s biological activity, making thorough exploration of its stereoisomers essential for understanding its behavior in biological systems.

This compound exemplifies the intricate relationship between structure and function in chemistry. As research continues, compounds like this may lead to innovative therapies and deepen our understanding of biochemical pathways. The explorations in this domain not only contribute to scientific knowledge but also underline the importance of complex molecules in the development of new treatments and drug discoveries.