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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one
State
State
At room temperature, estrone is a crystalline solid. Due to its solid-state, it does not emit vapors at normal circumstances, making it relatively stable in ambient conditions.
Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone is typically a white to off-white crystalline powder. It may appear slightly yellowish when impure or exposed to light over time. The compound's crystalline structure and aesthetic can vary slightly depending on its purity and form.

Comment on solubility

Solubility of (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of organic compounds like (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one often depends on several factors. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar Solvents: This compound possesses multiple hydroxyl (–OH) groups, which generally enhances its solubility in polar solvents such as water and alcohols.
  • Molecular Size: Its relatively large molecular structure might decrease solubility in extremely polar solvents, but could still remain soluble in less polar organic solvents.
  • Hydrogen Bonding: The presence of hydroxyl groups facilitates hydrogen bonding, likely increasing solubility in certain conditions.
  • Temperature Impact: As with many compounds, solubility may increase with temperature. Therefore, heating the solvent could lead to greater dissolving capacity.
  • pH Dependence: Changes in pH can alter the ionization state of the hydroxyl groups, potentially influencing solubility in aqueous environments.

In summary, the solubility of this compound can be characterized as being potentially soluble in polar solvents due to its functional groups, although its larger molecular structure might pose some limitations in very polar environments. Understanding these aspects of solubility is crucial for practical applications in chemical processes.

Interesting facts

Interesting Facts About (8S,13S,14S,17S)-17-Hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one

This compound belongs to a fascinating class of organic compounds known as steroids. Its unique structure, featuring multiple fused rings, is characteristic of steroids, which play vital roles in numerous biological systems. Here are some engaging points about this compound:

  • Biological Relevance: Steroid hormones derived from compounds like this are crucial for various physiological processes, including metabolism, immune response, and development.
  • Structural Complexity: The intricate arrangement of chiral centers in this compound contributes to its specific biological activity. As a result, enantiomers can exhibit significantly different behaviors in biological systems.
  • Potential Therapeutic Uses: Compounds structurally related to this one are often investigated for their potential applications in medicine, particularly in areas such as hormone replacement therapy and anabolic steroids.
  • Synthesis Challenges: The synthesis of such complex organic molecules is a challenging task that often involves multiple steps and can require sophisticated techniques in organic chemistry.
  • Research Significance: Chemists are continually exploring the analogs of this compound to discover new ways of modifying the structure for enhanced potency or reduced side effects in pharmacological applications.

In summary, the structural and functional properties of (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one showcase the beauty and complexity of organic chemistry. Its study not only helps in advancing scientific understanding but also holds potential for groundbreaking medical advancements.

Synonyms
Trenbolone
10161-33-8
Trienbolone
(+)-Trenbolone
17-beta-Trenbolone
Trenbolonum
Finajet
Trembolona
beta-Trenbolone
17-beta-Hydroxyestra-4,9,11-trien-3-one
CCRIS 1654
RU 2341
Trenbolonum [INN-Latin]
Trembolona [INN-Spanish]
UNII-P53R4420TR
BRN 5756203
CHEBI:35018
P53R4420TR
ESTRA-4,9,11-TRIEN-3-ONE, 17-beta-HYDROXY-
RU-2341
Estra-4,9,11-trien-3-one, 17-hydroxy-, (17-beta)-
17beta-Hydroxyestra-4,9,11-trien-3-one
Trenbolonum (INN-Latin)
Trembolona (INN-Spanish)
(17beta)-17-hydroxyestra-4,9,11-trien-3-one
trienolone
9,10,11,12-Dehydro-19-nortestosterone
estra-4,9,11-trien-17beta-ol-3-one
trenbolona
17beta-Trenbolone
DTXSID0034192
Trenbolone (INN)
TRENBOLONE [INN]
(8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one
DTXCID8014192
(8S,13S,14S,17S)-17-hydroxy-13-methyl-1,2,6,7,8,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
Trenbolone (1.0 mg/mL in Acetonitrile)
CAS-10161-33-8
Trenbolone [INN:BAN]
17B-Trenbolone
Estra-4,9,11-trien-3-one, 17-hydroxy-, (17b)-
TRENBOLONE [MI]
TRENBOLONE [WHO-DD]
SCHEMBL141915
(+)-Trenbolone;|A-Trenbolone
CHEMBL3182355
Estra-4,9,11-trien-3-one, 17-hydroxy-, (17.beta.)-
BCP12545
Trenbolone, 1mg/ml in Acetonitrile
Tox21_200539
Tox21_303654
MFCD00214395
AKOS015894852
MSK2275-1000M
Trenbolone 1.0 mg/ml in Acetonitrile
CS-1417
DB11551
3-oxo-estra-4,9,11-triene-17b-ol
NCGC00248686-01
NCGC00257511-01
NCGC00258093-01
HY-17433
Trenbolone 100 microg/mL in Acetonitrile
17-b-Hydroxyestra-4,9,11-trien-3-one
17beta-Hydroxyestr-4,9,11-trien-3-one
NS00007300
Trenbolone Solution in Methanol, 1000ug/mL
D08627
Q904833
Trenbolone, analytical standard, for drug analysis
Estra-4,9,11-trien-3-one, 17-hydroxy-, (17.beta)-