Interesting facts
Interesting Facts About the Compound
This compound, known for its complex structure and significant biological activity, is a member of the steroid family. It features a fully saturated cyclopenta[a]phenanthrene framework, which is integral to its function in biological systems. Here are some intriguing aspects of this compound:
- Structural Complexity: The intricate stereochemistry and numerous chiral centers contribute to its unique configuration, with specific stereoisomers often exhibiting varying biological activities.
- Pharmacological Importance: This molecule is studied for its potential medicinal properties, particularly in the realms of hormone replacement therapy and treatment of certain cancers. Compounds with similar frameworks are often found in pharmaceuticals.
- Mechanism of Action: It operates through the modulation of hormone receptors, affecting gene expression and cellular function. This action is particularly pertinent in the study of endocrine-related disorders.
- Natural Occurrence: Interestingly, many compounds related to this structure are derived from natural sources, demonstrating nature's remarkable ability to produce complex organic molecules that can interact with biological systems.
- Research Significance: Researchers continue to explore this compound as a lead for the development of more effective therapeutic agents, thanks to its fascinating properties and potential as a scaffold for synthetic modifications.
In conclusion, the exploration of this compound extends beyond its chemical formula. Its structural characteristics and biological implications make it a captivating subject of research within the chemical and pharmaceutical sciences.
Synonyms
CLOBETASOL PROPIONATE
25122-46-7
Clobetasol 17-propionate
Clobex
Dermovate
Temovate
Embeline
Cormax
Olux
Embeline E
Temovate E
Olux-E
Impoyz
Psorex
CCI 4725
GR 2/925
clobetasol 17-propanoate
Olux E
[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Clarelux
Dovate
Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)-
Clobetasol propionate gel
CCI-4725
IMPEKLO
CLOBETASOL PROPIONATE (EMOLLIENT)
DTXSID6045907
CHEBI:31414
NSC-758634
DTXCID4025907
779619577M
GR-2/925
21-chloro-9-fluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
Clobetavix
Clobaderm
Etrivex
Clodan
Dermovate nn
((8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta(a)phenanthren-17-yl) propanoate
RefChem:5696
Clobetasol 17 Propionate
Clobetasol Propionate ANDA
Clobetasol Propionate Cream
Tovet (emollient formulation)
Clobetasol Propionate, Hydrocolloid
Clobetasol Propionate USP, 0.05%
Clobetasol Propionate Cream, 0.05%
Clobetasol Propionate Ointment, 0.05%
Clobetasol Propionate Cream USP, 0.05%
Clobetasol Propionate Emollient Formulation
Clobetasol Propionate Ointment USP, 0.05%
Clobetasol Propionate Cream, 0.05% Clobetasol Propionate Cream, 0.05%
Clobetasol Propionate Cream USP, 0.05% Clobetasol Propionate Cream USP, 0.05%
21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propanoate
C25H32ClFO5
MFCD00058499
Clobetasol-17-propionate
21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
MLS000028708
SMR000058745
MLS001076345
Clobesol
Dermoxinale
Butavate
Dermoval
Yugofin
Clobetasolpropionate
CGP 9555
EINECS 246-634-3
NCGC00095078-01
Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11.beta.,16.beta.)-
clobetasol-propionate
CAS-25122-46-7
Clobex (TN)
Cormax (TN)
UNII-779619577M
Clobestasol propionate
Clobetasol propionate [USAN:USP:JAN]
Olux (TN)
Clobetasol propionate E
Opera_ID_1470
SCHEMBL3997
21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-
cid_32798
GTPL7062
CHEMBL1159650
Clobetasol propionate (Standard)
BDBM39347
MSK2237
CBGUOGMQLZIXBE-XGQKBEPLSA-N
CLOBETASOL PROPIONATE [MI]
HMS2090A04
HMS2230H08
HMS3259A10
HMS3714M04
Clobetasol propionate (JP17/USP)
CLOBETASOL PROPIONATE [JAN]
BCP04125
CLOBETASOL PROPIONATE [USAN]
Tox21_111414
CLOBETASOL PROPIONATE [VANDF]
HY-13600R
s2584
CLOBETASOL PROPIONATE [MART.]
AKOS015951278
CLOBETASOL PROPIONATE [USP-RS]
CLOBETASOL PROPIONATE [WHO-DD]
Tox21_111414_1
BCP9000539
CCG-220781
CLOBETASOL 17-PROPIONATE [MI]
DB01013
FC20489
NC00551
NSC 758634
21-Chloro-9-fluoro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
NCGC00023373-03
NCGC00023373-04
AC-17990
AS-12555
Clobetasol propionate, analytical standard
CPD000058745
HY-13600
Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate
SY060191
BCP0726000094
CLOBETASOL PROPIONATE [ORANGE BOOK]
CLOBETASOL PROPIONATE [USP IMPURITY]
C2612
CLOBETASOL PROPIONATE [USP MONOGRAPH]
NS00000111
D01272
D94623
AB00383081-10
AB00383081_11
EN300-7480850
122C467
Q421637
SR-01000000280
SR-01000000280-4
BRD-K10799896-001-10-6
BRD-K10799896-001-24-7
BRD-K10799896-001-26-2
Clobetasol propionate, European Pharmacopoeia (EP) Reference Standard
Clobetasol propionate, United States Pharmacopeia (USP) Reference Standard
Clobetasol for peak identification, European Pharmacopoeia (EP) Reference Standard
Clobetasol Propionate, Pharmaceutical Secondary Standard; Certified Reference Material
(11?,16?)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
(11b,16b)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
(1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-1-(2-chloroacetyl)-9b-fluoro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
(8alpha,11beta,14beta,16alpha,17alpha)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate
CGP9555 pound>> CCl 4725 pound>>CGP 9555 pound>> CCl4725 pound>>CGP-9555 pound>> CCl-4725
Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11|A,16|A)-
XRD
Solubility of the Compound
The solubility of the compound [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate can vary based on several factors:
In conclusion, predicting the solubility behavior of such a complex compound often requires experimental determination, considering the interplay between its structural characteristics and the solvent environment. As with many organic compounds, like dissolves like serves as a useful guideline, with polar solvents favored for solubilizing polar compounds.