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Hydrocortisone

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
(8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, hydrocortisone is typically in a solid state.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
560.20
Boiling point (Kelvin)
833.35
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.2800g/cm3
Appearence

Hydrocortisone appears as a white to practically white, odorless, crystalline powder.

Comment on solubility

Solubility Insights

The compound (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta+phenanthren-3-one presents intriguing considerations regarding its solubility.

Factors Influencing Solubility

Several factors can affect the solubility of this complex organic molecule:

  • Molecular Structure: The multiple chiral centers and the presence of functional groups can significantly influence solubility in different solvents.
  • Polarity: Generally, compounds that are polar tend to dissolve well in polar solvents, while nonpolar compounds are more soluble in nonpolar solvents.
  • Temperature: Increasing temperature tends to enhance solubility for most solid solutes.
  • pH and Ionic Strength: These parameters can also influence solubility, especially in cases where ionizable functional groups are present.

Solubility Characteristics

In general, for molecules like this one:

  • They may demonstrate limited solubility in water due to hydrophobic characteristics.
  • They are likely to be more soluble in organic solvents such as dichloromethane, ethyl acetate, or alcohols.
  • The presence of the acetyl group may enhance solubility in certain nonpolar solvents.

Understanding the solubility of this compound not only aids in practical applications but also paves the way for exploring its potential reactivity and interactions with other molecules in various environments.

Interesting facts

Interesting Facts about (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

This intriguing compound, often found in the realm of synthetic organic chemistry, is noteworthy for its complex structure and unique properties. Here are some impressive facts about it:

  • Stereochemistry: The detailed stereochemical specifications indicate that this compound possesses multiple asymmetric centers, which contribute to its potential optical activity. The arrangement of these configurations could influence its biological interactions significantly.
  • Biological Relevance: Compounds of this type can exhibit important pharmacological properties, making them valuable in medicinal chemistry. They might serve as potential leads in drug development for various therapeutic areas such as oncology or hormonal therapies.
  • Synthetic Pathways: The synthesis of this compound may involve intricate multi-step organic reactions, showcasing the creativity and precision of chemists. Understanding the reaction mechanisms behind this compound can provide insights into reaction conditions and methods of functional group manipulation.
  • Structural Features: The presence of the acetyl group suggests that this compound could be involved in acetylation reactions, which are critical in modifying the activity of various molecules, particularly in biological contexts.
  • Potential Applications: Given its structure, this compound could be investigated for its potential use in designing new materials or in biochemical applications, such as serving as a probe in biological imaging.

As a student of chemistry, delving into compounds like this can enhance your appreciation for the vast diversity and complexity found within organic molecules. Exploring their properties and reactions not only builds a solid foundation of knowledge but also sparks curiosity for future research and applications. Remember, every unique arrangement and functional group could pave the way for innovative discoveries!

Synonyms
dydrogesterone
152-62-5
Isopregnenone
Hydrogesterone
Duphaston
Hydrogestrone
Gynorest
Gestatron
Diphaston
Dufaston
Duvaron
Prodel
Retrone
Terolut
10alpha-Isopregnenone
Didrogesterone
Dydrogesteronum
Retro-6-dehydroprogesterone
delta(6)-Retroprogesterone
Didrogesterone [DCIT]
didrogesterona
6-Dehydro-retro-progesterone
Dydrogesterona
delta(sup 6)-Retroprogesterone
Dydrogesteronum [INN-Latin]
Dydrogesterona [INN-Spanish]
9beta,10alpha-Pregna-4,6-diene-3,20-dione
Retroprogesterone, 6-dehydro-
NSC 92336
6-Dehydro-9beta,10alpha-progesterone
CCRIS 9069
HSDB 3321
6-Dehydroretroprogesterone
(8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
EINECS 205-806-8
UNII-90I02KLE8K
NSC-92336
9-beta,10alpha-Pregna-4,6-diene-3,20-dione
90I02KLE8K
DTXSID1022974
(9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione
CHEBI:31527
Pregna-4,6-diene-3,20-dione, (9beta,10alpha)-
(9beta,10alpha)-pregna-4,6-diene-3,20-dione
9-beta,10-alpha-Pregna-4,6-diene-3,20-dione
MLS002153947
DTXCID702974
Dehydrogesterone
NSC92336
Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-
Dydrogesterone [USAN:USP:INN:BAN:JAN]
Dydrogesteronum (INN-Latin)
Dydrogesterona (INN-Spanish)
DYDROGESTERONE (MART.)
DYDROGESTERONE [MART.]
DYDROGESTERONE (USP-RS)
DYDROGESTERONE [USP-RS]
DYDROGESTERONE (EP MONOGRAPH)
DYDROGESTERONE [EP MONOGRAPH]
DYDROGESTERONE (USP MONOGRAPH)
DYDROGESTERONE [USP MONOGRAPH]
Duphaston (TN)
Gynorest (TN)
CAS-152-62-5
Dydrogesterone (USAN:USP:INN:BAN:JAN)
6-Dehydro-9 beta-10 alpha-progesterone
MLS002695106
dibrogesterone
6 Dehydro 9 beta 10 alpha progesterone
Dydrogesterone; 9beta,10alpha-Pregna-4,6-diene-3,20-dione
Dydrogesterone?
NCGC00016413-01
10alpha-pregna-4,6-diene-3,20-dione
Dehydro-retroprogesterone
6-Dehydro-9.beta.,10.alpha.-progesterone
Prestwick0_000671
Prestwick1_000671
Prestwick2_000671
Prestwick3_000671
Dydrogesterone (Standard)
DYDROGESTERONE [MI]
Pregna-4,6-diene-3,20-dione, (9b,10a)-
.DELTA.6-Retroprogesterone
DYDROGESTERONE [INN]
DYDROGESTERONE [JAN]
SCHEMBL37703
BSPBio_000761
DYDROGESTERONE [HSDB]
DYDROGESTERONE [USAN]
SPBio_002682
BPBio1_000839
GTPL2878
HY-B0257AR
DYDROGESTERONE [WHO-DD]
CHEMBL1200853
HY-B0257A
9.beta.,6-diene-3,20-dione
G03DB01
Dydrogesterone (JP17/USP/INN)
HMS1570G03
HMS2097G03
HMS2230C10
HMS3714G03
9-.beta.,6-diene-3,20-dione
BCP12878
DYDROGESTERONE [ORANGE BOOK]
Tox21_110429
s4097
AKOS015895532
Tox21_110429_1
CCG-220671
DB00378
FD22631
GS-6735
NCGC00179445-01
NCGC00179445-03
NCGC00179445-04
SMR001233286
AB00513884
NS00009687
D01217
H10151
Pregna-4,20-dione, (9.beta.,10.alpha.)-
AB00513884_04
EN300-19767791
SR-01000841256
Q4161380
SR-01000841256-2
BRD-K68620903-001-03-1
BRD-K68620903-001-09-8
BRD-K68620903-001-11-4
PREGNA-4,6-DIENE-3,20-DIONE, (9beta,10alpha)
PREGNA-4,6-DIENE-3,20-DIONE, (9.BETA.,10.ALPHA.)
(9b,10a)-Pregna-4,6-diene-3,20-dione;6-Dehydroretroprogesterone;Retrone
(1R,2S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,8-dien-5-one
(1S,3aS,3bS,9aS,9bR,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
205-806-8