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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

Corticosterone is a solid at room temperature.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
553.00
Boiling point (Kelvin)
826.15
General information
Molecular weight
346.46g/mol
Molar mass
346.4630g/mol
Density
1.3000g/cm3
Appearence

Corticosterone is typically found as a white crystalline powder.

Comment on solubility

Solubility of the Compound

The compound (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one demonstrates intricate solubility characteristics due to its complex structure. The solubility of this compound is influenced by several factors:

  • Molecular Structure: The presence of multiple hydroxyl (-OH) groups tends to enhance solubility, particularly in polar solvents like water.
  • Hydrophobic Regions: The dodecahydrocyclopenta[a]phenanthren moiety may introduce hydrophobic characteristics, potentially reducing solubility in highly polar solvents.
  • pH Dependency: The solubility can vary with pH levels, as the presence of hydroxy groups may result in ionization in different pH conditions.

Considering these factors, the overall solubility of the compound can be described as:

  • More soluble in polar solvents due to hydrogen bonding capabilities.
  • Less soluble in non-polar solvents owing to its hydrophobic regions.
  • Subject to variability based on temperature and solvent composition.

In conclusion, the solubility of this compound can be characterized as moderate to high in polar solvents, with notable decreases in lipophilic environments.

Interesting facts

Interesting Facts about (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

This complex compound, often referred to in scientific circles for its intricate structure, is a fascinating example of molecular architecture. Here are some key points of interest:

  • Structural Complexity: The compound features a multi-ring system, showcasing a dodecahydrocyclopenta[a]phenanthrene core. This intricate arrangement is a prime example of nature's ability to create complex molecules from simple building blocks.
  • Biological Relevance: Compounds with similar structures are often investigated in pharmacology and biochemistry for their potential therapeutic effects. Their unique configurations can interact in specific ways with biological systems, leading to various biological activities.
  • Functional Groups: The presence of diverse functional groups, such as hydroxyl and hydroxyacetyl, indicates potential sites for reactivity. These groups are known for their role in enhancing the solubility and bioactivity of organic compounds.
  • Stereochemistry: The multiple stereocenters in this compound contribute to its specific three-dimensional arrangement, which is crucial in drug design and development. Stereochemistry plays a significant role in how compounds interact with biological targets.
  • Research Applications: Scientists may explore this compound for its potential in treating various diseases, including hormonal disorders and cancers, due to its structural similarities to known bioactive molecules.

In summary, the study of (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one not only enriches our understanding of complex organic compounds but also opens avenues for potential therapeutic innovations. As noted by chemists, "the more we understand about life’s molecular tapestry, the more we can innovate for health and well-being."

Synonyms
18-HYDROXYCORTICOSTERONE
11beta,18,21-Trihydroxypregn-4-ene-3,20-dione
UNII-4U5T0O9SI3
4U5T0O9SI3
EINECS 209-221-9
11beta,18,21-trihydroxy-pregn-4-ene-3,20-dione
CHEBI:16485
DTXSID80897516
11b,18,21-trihydroxy-pregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 11,18,21-trihydroxy-, (11.beta.)-
Pregn-4-ene-3,20-dione, 11,18,21-trihydroxy-, (11beta)-
PREGN-4-ENE-3,20-DIONE, 11.BETA.,18,21-TRIHYDROXY-
11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo(8.7.0.02,7.011,15)heptadec-6-en-5-one
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta(a)phenanthren-3-one
18 Hydrocorticosterone
18-Hydrocorticosterone
Hydroxycorticosterone, 18
18 HYDROXYCORTICOSTERONE
DTXCID601326871
(11beta)-11,18,21-Trihydroxypregn-4-ene-3,20-dione
PREGN-4-ENE-3,20-DIONE, 11BETA,18,21-TRIHYDROXY-
vpjhrehkrniydb-tzgxilgrsa-n
561-65-9
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
(8S,9S,10R,11S,13R,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
18-hydroxy corticosterone
SCHEMBL142427
HFSXHZZDNDGLQN-ZVIOFETBSA-N
EX-A10383
LMST02030091
18-Hydroxycorticosterone, 97% (CP)
AKOS027320497
AS-6177
CS-W013895
FH08456
HY-W013179
PD099481
NS00042786
4-Pregnene-11beta,18,21-triol-3,20-dione
C01124
Q3597767