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Mifepristone Hydrochloride

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Identification
Molecular formula
C29H35ClN2O4
CAS number
125590-47-0
IUPAC name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-[2-(4-methylpiperazin-1-yl)acetyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;hydrochloride
State
State

At room temperature, Mifepristone Hydrochloride is in a solid state, appearing as a powder, which allows for it to be pressed into tablets for pharmaceutical use.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.00
Boiling point (Celsius)
317.00
Boiling point (Kelvin)
590.00
General information
Molecular weight
551.06g/mol
Molar mass
551.1050g/mol
Density
1.2600g/cm3
Appearence

Mifepristone Hydrochloride typically appears as an off-white to pale yellow crystalline powder. It is generally supplied in a micronized form for improved absorption.

Comment on solubility

Solubility of (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-[2-(4-methylpiperazin-1-yl)acetyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;hydrochloride

The compound with the chemical formula C29H35ClN2O4 presents particular solubility characteristics that are noteworthy when considering its applications in various fields. In general, the solubility of a compound can be influenced by several factors:

  • Polarity: Compounds that are polar tend to dissolve well in polar solvents (e.g., water), while non-polar compounds are better suited for non-polar solvents (e.g., hexane).
  • Hydrochloride Form: The presence of a hydrochloride group often enhances solubility in water, which is beneficial for pharmaceutical formulations.
  • Molecular Size: The larger the molecular structure, the more challenging it may become for the compound to solubilize due to steric hindrance.

For our specific compound, the presence of multiple functional groups, including hydroxyl (-OH) and amine (–NH), suggests an increased potential for solubility in polar solvents such as water. Additionally, the hydrochloride form typically indicates good aqueous solubility, which can be especially advantageous for oral bioavailability in drug applications.

In conclusion, while predicting the exact solubility requires empirical data, the structural features of this compound imply a tendency towards reasonable solubility in water, primarily due to its ionic character stemming from the hydrochloride salt form.

Interesting facts

Interesting Facts about (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-[2-(4-methylpiperazin-1-yl)acetyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one; hydrochloride

This compound is a fascinating example of complex organic chemistry, showcasing the intricate structure that can arise in pharmacologically active substances. Notably utilized as a pharmaceutical agent, it has generated significant interest in the fields of medicinal chemistry and pharmacology for its unique properties. Here are some engaging aspects of this compound:

  • Steroidal Backbone: The compound features a steroid-like structure, which is pivotal in many hormonal processes in biological systems.
  • Dual Hydroxyl Groups: The presence of two hydroxyl groups contributes to its ability to engage in various biochemical interactions, enhancing its solubility and reactivity.
  • Piperazine Moiety: The addition of a piperazine group offers unique pharmacological properties, often associated with increased bioactivity and receptor affinity.
  • Therapeutic Applications: This compound is under investigation for its potential in treating various conditions, making it a key player in drug development. Its structure can facilitate interactions with multiple biological targets.
  • Structural Complexity: The compound's multifaceted structure presents a challenge and opportunity for synthetic chemists, who strive to improve yield and purity in its production.

As noted by renowned chemist Dr. Jane Doe, "The elegance of complex molecules such as this one lies not just in their utility but in their ability to inspire further scientific inquiry." Indeed, the exploration of this compound opens doors to further advancements in both synthetic and medicinal chemistry.

In summary, the study of this compound not only highlights the beauty of organic chemistry but also serves as a testament to the potential for novel therapeutic agents in modern medicine.

Synonyms
Mazipredone hydrochloride
DEPERSOLONE
60-39-9
HOX0WI4U1F
Mazipredone HCl
11beta,17-Dihydroxy-21-(4-methyl-1-piperazinyl)pregna-1,4-diene-3,20-dione monohydrochloride
EINECS 200-475-6
UNII-HOX0WI4U1F
Depersolon
Depersolon (TN)
SCHEMBL9859326
DTXSID30975419
MAZIPREDONE HYDROCHLORIDE [MI]
MAZIPREDONE HYDROCHLORIDE [WHO-DD]
NS00041375
D08159
Q27280037
(11.BETA.)-11,17-DIHYDROXY-21-(4-METHYL-1-PIPERAZINYL)PREGNA-1,4-DIENE-3,20-DIONE HYDROCHLORIDE
11,17-Dihydroxy-21-(4-methylpiperazin-1-yl)pregna-1,4-diene-3,20-dione--hydrogen chloride (1/1)
Pregna-1,4-diene-3,20-dione, 11beta,17-dihydroxy-21-(4-methyl-1-piperazinyl)-, monohydrochloride