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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, corticosterone is in a solid crystalline state.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
346.46g/mol
Molar mass
346.4610g/mol
Density
1.3025g/cm3
Appearence

Corticosterone typically appears as a white crystalline powder. It is odorless and stable under normal conditions.

Comment on solubility

Solubility of (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound C21H30O4 can present a fascinating profile influenced by various factors. Here are some key points regarding its solubility:

  • Polar and Non-polar Characteristics: The presence of hydroxyl (–OH) groups suggests that the compound has some polar characteristics, which may enhance solubility in polar solvents such as water. However, the larger hydrocarbon structure tends to contribute to non-polar solubility.
  • Solvent Choice: Given its structure, the compound is likely more soluble in organic solvents like ethanol, methanol, and acetone, while having limited solubility in water.
  • Temperature Influence: Generally, solubility can increase with temperature. Thus, heating may improve the dissolution of this compound in appropriate solvents.

As stated, "solubility is a key factor in determining the potential applications and effectiveness of chemical compounds." Hence, understanding the solubility of C21H30O4 is crucial for its utilization in various chemical processes and industries.

In summary, when exploring the solubility aspects of this compound, it is important to consider its structural characteristics, the choice of solvent, and external conditions such as temperature. Overall, its solubility can be complex and warrants careful investigation.

Interesting facts

Interesting Facts about (8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

This fascinating compound has garnered significant attention in the fields of natural products and medicinal chemistry due to its complex structure and potential biological activities. Here are some intriguing aspects of this molecular entity:

  • Source: The compound is structurally related to steroidal compounds, which often reflect nature’s elaborate mechanisms for creating biologically active substances.
  • Biological Activity: Preliminary studies have indicated that compounds with similar frameworks may exhibit important pharmacological properties, including anti-inflammatory and anticancer activities.
  • Structure-Activity Relationship: The specific stereochemistry denoted by the (S) and (R) notations in the name suggests that this compound's configuration is critical in determining its activity and interactions at the molecular level.
  • Research Applications: Compounds like this one are essential in drug design and discovery, allowing scientists to fine-tune their chemical structures for improved efficacy.

Moreover, understanding the intricate details of such a compound requires a multidisciplinary approach, combining aspects of organic chemistry, biochemistry, and pharmacology. As the renowned chemist Linus Pauling once said, “The best way to have a good idea is to have a lot of ideas.” This aphorism holds true in the ongoing exploration of novel compounds and their potential impacts on health and disease.

As research continues, the dual focus on structural understanding and biological implications promises a bright future for analogous compounds, paving the way for innovative therapeutic strategies.

Synonyms
CORTICOSTERONE
50-22-6
17-Deoxycortisol
Kendall's compound B
Reichstein's substance H
Corticosteron
11beta,21-Dihydroxyprogesterone
Reichstein's B
11-Hydroxycorticoaldosterone
(11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
11beta,21-Dihydroxy-4-pregnene-3,20-dione
4-Pregnene-11beta,21-diol-3,20-dione
11Beta,21-dihydroxypregn-4-ene-3,20-dione
NSC-9705
11,12-Dihydroxyprogesterone
11,21-Dihydroxyprogesterone
CCRIS 6753
Compound B nach Kendall
CHEBI:16827
11-beta,21-Dihydroxypregn-3,20-dione
11-beta,21-Dihydroxyprogesterone
Substanz H nach Reichstein
4-Pregnene-11-beta,21-diol-3,20-dione
NSC 9705
EINECS 200-019-6
BRN 2339601
Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-
DTXSID6022474
Pregn-4-ene-3,20-dione, 11-beta,21-dihydroxy-
(11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
NSC9705
W980KJ009P
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CORTICOSTERONE [MI]
MLS000028536
CHEMBL110739
DTXCID702474
4-Pregnene-11.beta.,21-diol-3,20-dione
11.beta.,21-Dihydroxyprogesterone
(11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione
11-b,21-Dihydroxypregn-3,20-dione
NCGC00022472-05
SMR000058318
Corticosterone 100 microg/mL in Acetonitrile
Preg-4-ene-3,20-dione,11-b,21-dihydroxy-
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
SR-01000075748
Cortico
UNII-W980KJ009P
Compd B
CAS-50-22-6
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one
Prestwick_672
Kendalls Compound B
MFCD00037715
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11b)-
Reichsteins Substance H
21-dihydroxyprogesterone
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE
Opera_ID_1519
Prestwick0_000432
Prestwick1_000432
Prestwick2_000432
Prestwick3_000432
Corticosterone (Standard)
Corticosterone, >=92%
11-.beta.,20-dione
bmse000669
Epitope ID:152207
BIDD:PXR0063
Lopac0_000220
SCHEMBL22612
BSPBio_000444
4-Pregnene-11 Corticosteron
MLS001074095
MLS001424305
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11.beta.)-
BIDD:ER0495
SPBio_002383
BPBio1_000490
GTPL2869
HY-B1618R
Corticosterone, BRN 2339601
4-Pregnene-11.beta.,20-dione
HMS1569G06
HMS2052G21
HMS2090A08
HMS2096G06
HMS2231F16
HMS3260L21
HMS3713G06
HMS3885H22
Corticosterone, 1mg/ml in Methanol
HY-B1618
Tox21_110879
Tox21_201366
Tox21_303642
Tox21_500220
BDBM50170653
CMC_13412
HB2808
HSCI1_000383
LMST02030186
s4752
STL564760
Corticosterone, >=98.5% (HPLC)
AKOS016008541
Tox21_110879_1
CCG-101146
CS-5105
DB04652
FC20555
LP00220
NC00396
SDCCGSBI-0050208.P002
SMP1_000079
NCGC00022472-06
NCGC00022472-07
NCGC00022472-08
NCGC00022472-10
NCGC00022472-17
NCGC00091029-01
NCGC00256539-01
NCGC00258918-01
NCGC00260905-01
11|A
AS-75743
DA-52062
11,21-Dihydroxypregn-4-ene-3,20-dione
11-.beta.,21-Dihydroxypregn-3,20-dione
11b,21-Dihydroxy-4-pregnene-3,20-dione
Pregn-4-ene-3, 11.beta.,21-dihydroxy-
4-Pregnen-11.beta.,21-diol-3,20-dione
EU-0100220
NS00000569
C 2505
C02140
D94656
11.beta.,21-dihydroxypregn-4-ene-3,20-dione
Corticosterone, VETRANAL(TM), analytical standard
Q422543
SR-01000000082
Pregn-4-ene-3,20-dione, 11.beta.,21-dihydroxy-
SR-01000000082-3
SR-01000075748-1
SR-01000075748-4
WLN: L E5 B666 OV MUTJ A1 CQ E1 FV1Q
(11beta)-11,21-Dihydroxypregn-4-ene-3,2 0-dione
BRD-K73589401-001-04-6
BRD-K73589401-001-23-6
Pregn-4-ene-3, 11,21-dihydroxy-, (11.beta.)-
(9beta,11alpha)-11,21-dihydroxypregn-4-ene-3,20-dione
11,21-Dihydroxypregn-4-ene-3,20-dione, (11.beta.)- #
4793EB71-D789-498E-B641-C5C1C377B9FF
17-Deoxycortisol;11,21-Dihydroxyprogesterone;Kendall's compound B
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-beta)- (9CI)
Kendall's Compound B; 4-Pregnene-11beta,21-diol-3,20-dione; Reichstein's Substance H
(11b)-11,21-Dihydroxy-pregn-4-ene-3,20-dione;11,21-Dihydroxyprogesterone;17-Deoxycortisol
200-019-6