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Cortisone

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Identification
Molecular formula
C21H28O5
CAS number
53-06-5
IUPAC name
(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State
Cortisone is generally found as a solid under standard conditions of temperature and pressure.
Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
540.32
Boiling point (Kelvin)
813.47
General information
Molecular weight
360.44g/mol
Molar mass
360.4440g/mol
Density
1.3000g/cm3
Appearence

Cortisone appears as a white crystalline powder. It is known for its characteristic structure that does not readily melt, and has a mild odor.

Comment on solubility

Solubility Characteristics

The compound (8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one exhibits specific solubility traits that are important to consider in various applications.

Key Solubility Aspects

  • Polarity: The presence of multiple hydroxyl (−OH) groups typically increases polar character, suggesting a higher likelihood for solubility in polar solvents like water.
  • Hydrophobic Components: The extensive hydrocarbon framework contributes to hydrophobic interactions, which can reduce solubility in water.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents such as ethanol or methanol, where similar hydrophobic regions can interact favorably.
  • Temperature Influence: Generally, solubility may increase with temperature, allowing for higher concentrations at elevated conditions in suitable solvents.

In summary, while the compound displays potential for solubility in polar environments due to its hydroxyl groups, the significant hydrophobic sections may limit its solubility in water. It is essential to select appropriate solvents based on the intended use to maximize dissolving capabilities.

Interesting facts

Interesting Facts about 11,17-Dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This complex compound, derived from the phenanthrene family, holds a fascinating place in the realm of organic chemistry. Its intricate structure acts as a great example of how subtle variations in molecular configuration can lead to diverse biological activities. Here are some intriguing aspects of this compound:

  • Natural Hormonal Influence: The compound is structurally similar to steroid hormones, potentially impacting various biological processes, including growth and metabolism.
  • Potential Therapeutic Applications: Research indicates that compounds of this type may exhibit anti-inflammatory properties, making them candidates for the development of therapeutic agents.
  • Biological Variability: The presence of multiple stereocenters in its composition hints at the possibility of various stereoisomers, each potentially exhibiting unique biological activities.
  • Environmental Stability: Due to its robust and stable structure, compounds like this may be resistant to environmental degradation, thus persisting longer in biological samples.
  • Synthetic Challenges: The synthesis of such intricate compounds often poses significant challenges, calling for advanced techniques in organic synthesis and purification.

As scientists continue to explore the potential of this compound, it serves as a reminder of the complexity and beauty in organic chemistry. With each new discovery, we thrill at the possibility of uncovering new applications that can benefit society and enhance our understanding of biochemical interactions.

Synonyms
1043-10-3
Testosterone, 11beta-hydroxy-17-methyl-
11beta,17beta-Dihydroxy-17-methylandrost-4-en-3-one
U 5437
U-5437
17-alpha-Methyl-11-beta,17-dihydroxy-4-androsten-3-one
CHEBI:34140
408KJY51K3
NSC-3359
NSC-11677
(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Testosterone, 11.beta.-hydroxy-17-methyl-
Androst-4-ene-3-one, 11,17-dihydroxy-17-methyl-, (11-beta,17-beta)-
11,17-Dihydroxy-17-methylandrost-4-ene-3-one, (11-beta,17-beta)-
NSC 3359
11-BETA-HYDROXY-17-METHYL-TESTOSTERONE
EINECS 213-871-9
NSC 11677
BRN 3214017
UNII-408KJY51K3
BA 51-08943
17alpha-Methyl-11beta,17-dihydroxy-4-androsten-3-one
Androst-4-en-3-one, 11beta,17beta-dihydroxy-17-methyl-
4-08-00-02056 (Beilstein Handbook Reference)
CHEMBL486288
SCHEMBL6804668
DTXSID60146377
NSC3359
ANDROST-4-EN-3-ONE, 11-beta,17-beta-DIHYDROXY-17-METHYL-
NSC11677
Androst-4-en-3-one, 11,17-dihydroxy-17-methyl-, (11beta,17beta)-
11beta-Hydroxy-17alpha-methyltestosterone
NS00023294
Q27115842
(11-beta,17-beta)-11,17-dihydroxy-17-methylandrost-4-ene-3-one
ANDROST-4-EN-3-ONE,11.BETA.,17.BETA.-DIHYDROXY-17-METHYL-