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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
State
State

At room temperature, estrone exists as a solid.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.00
Boiling point (Celsius)
545.70
Boiling point (Kelvin)
818.90
General information
Molecular weight
270.37g/mol
Molar mass
270.3670g/mol
Density
1.2300g/cm3
Appearence

Estrone is a white to off-white crystalline powder. It is odorless and tasteless.

Comment on solubility

Solubility Insights

The compound (8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione exhibits interesting solubility behavior influenced by its structural characteristics.

Key points regarding its solubility include:

  • Polarity: The presence of hydroxyl groups usually increases solubility in polar solvents, such as water, although the overall large hydrophobic structure may limit this effect.
  • Solvent Compatibility: It is likely more soluble in organic solvents like ethanol, acetone, or chloroform due to its non-polar decahydrocyclopenta component excitedly interacting with non-polar solvation environments.
  • Temperature Effects: Solubility often improves with increased temperature, so heating the solvent may enhance dissolution.

As a general rule, predicting solubility can be complex and is often evaluated experimentally. The phrase “like dissolves like” resonates well here, emphasizing the need for matching polarities between the solute and solvent for optimal solubility.

Therefore, while this compound has a structure that may naturally lean towards lower solubility in water, understanding its solubility demands careful consideration of the solvent types used and the functional groups present in the compound.

Interesting facts

Interesting Facts about (8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione

This complex compound, often referred to in scientific literature, serves as a fascinating example of intricate molecular architecture. Known for its biological significance, this compound plays a key role in various biochemical pathways:

  • Hormonal Activity: The compound is structurally related to steroid hormones, suggesting potential roles in hormonal regulation and function.
  • Potential Therapeutic Applications: Due to its unique structure, it has been studied for its potential in pharmaceuticals, particularly as it may influence cellular signaling pathways.
  • Natural Precursor: This compound is biosynthetically related to natural products found in certain plants, making it a candidate for natural product synthesis and drug development.

From a synthetic chemist's perspective, the complexity of this molecule poses both a challenge and an opportunity:

  • Complex Synthesis: Synthesizing this compound requires advanced techniques and a deep understanding of organic reaction mechanisms.
  • Research Value: Its intricate structure provides a rich subject for studies into stereochemistry and molecular interactions.

As one researcher wisely stated, "In every complex molecule, there lies a universe of potential waiting to be explored." Such compounds underscore the importance of interdisciplinary studies in chemistry, biology, and medicine, linking the fundamental aspects of molecular science with practical health applications.

In summary, examining the properties and implications of (8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione not only broadens our understanding of chemical compounds but also enhances our appreciation for the intricate connections within the biological sciences.

Synonyms
5419-48-7
U-4407
0WN7771B1H
17beta-Hydroxy-17alpha-methylandrost-4-en-3,11-dione
17beta-Hydroxy-17-methylandrost-4-ene-3,11-dione
NSC 9722
BRN 3158705
NSC-9722
Androst-4-ene-3,11-dione, 17-hydroxy-17-methyl-, (17beta)-
17beta-Hydroxy-17-methyl-4-androstene-3,11-dione
17-beta-Hydroxy-17-methyl-4-androstene-3,11-dione
Androst-4-ene-3,11-dione, 17beta-hydroxy-17-methyl-
ANDROST-4-ENE-3,11-DIONE, 17-beta-HYDROXY-17-METHYL-
Androst-4-ene-3,11-dione, 17-hydroxy-17-methyl-, (17.beta.)-
UNII-0WN7771B1H
CHEBI:34181
Androst-4-ene-3,11-dione, 17-hydroxy-17-methyl-, (17-beta)-
(8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
Q27115878
17.BETA.-HYDROXY-17-METHYLANDROST-4-ENE-3,11-DIONE
17.BETA.-HYDROXY-17.ALPHA.-METHYLANDROST-4-EN-3,11-DIONE
ANDROST-4-ENE-3,11-DIONE,17.BETA.-HYDROXY-17-METHYL-