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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(8S,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
State
State

At room temperature, estradiol is in a solid state.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
445.80
Boiling point (Kelvin)
718.95
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1700g/cm3
Appearence

Estradiol appears as a white or almost white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of (8S,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol

The solubility of the compound C18H24O2 can be influenced by several factors, particularly its unique molecular structure, which includes both hydrophobic and hydrophilic components. Here are some key points to consider:

  • Hydrophobic Regions: The presence of a large hydrophobic hydrocarbon framework contributes to low solubility in polar solvents like water.
  • Hydrophilic -OH Group: The hydroxyl (-OH) functional group can enhance solubility in polar solvents to some extent due to hydrogen bonding.
  • Solvent Interaction: In non-polar solvents (such as hexane), the compound is likely to dissolve well due to its hydrophobic nature.
  • Temperature Effects: Solubility may increase with temperature, as increased kinetic energy can enhance solvation processes.

Overall, the conflicting hydrophobic and hydrophilic characteristics suggest that while the compound may have limited water solubility, it can readily dissolve in organic solvents.

As stated in the realm of chemistry, "Like dissolves like." Therefore, understanding the compound's solubility is important for applications in various chemical environments.

Interesting facts

Interesting Facts about (8S,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol

This compound, a complex organic molecule, belongs to a class of steroids known for their potent biological activities. The structural intricacies of this compound underscore its significance in various fields, particularly in biochemistry and pharmacology.

Key Characteristics:

  • Unique Structure: The stereochemistry highlighted in its name indicates that this compound has multiple chiral centers, leading to a rich diversity of potential enantiomers and diastereomers, each with potentially different biological activities.
  • Natural Occurrence: Compounds with a similar structure are often found in natural sources such as plants and fungi, where they can serve as hormones or signaling molecules.
  • Biological Significance: The presence of hydroxyl (-OH) groups in cyclopenta[a]phenanthrenes has been associated with various physiological effects, including anti-inflammatory and anticancer properties.

In the realm of medicinal chemistry, this compound may offer a template for developing new therapeutic agents. As noted by researchers, "The intricate design of such steroids allows for targeted synthesis that can lead to novel treatments." The challenge lies in fully understanding its mechanism of action and potential side effects.

Furthermore, the study of compounds like this one invites an interdisciplinary approach, combining insights from organic chemistry, pharmacology, and even computational modeling to predict how modifications to its structure can enhance or diminish its biological efficacy.

Applications and Research:

  • Drug Development: This compound's complexity makes it an excellent candidate for drug design, particularly in the context of hormone-related therapies.
  • Research Tool: Its structure could serve as a starting point for synthesizing analogs that may reveal more about biological processes in cell signaling.
  • Environmental Studies: Understanding natural steroid compounds could also shed light on ecosystem dynamics and the role of plant-derived chemicals in ecological interactions.

In summary, (8S,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol is not just a compound of chemical interest; it opens doors to a myriad of scientific exploration, pushing the boundaries of our understanding of nature’s molecular machinery.

Synonyms
17-Deoxyestradiol
17-Desoxyestradiol
17-Deoxyestrone
Deoxoestrone
Estrone, 17-deoxy-
53-63-4
3-Hydroxyestra-1,3,5(10)-triene
17-Deoxyoestrone
ESTRA-1,3,5(10)-TRIEN-3-OL
17-deoxoestrone
17-Desoxyestrone
estra-1(10),2,4-trien-3-ol
OESTRA-1,3,5(10)-TRIEN-3-OL
CHEMBL261406
CHEBI:62844
73A01W88SP
NSC-57428
CCRIS 7204
NSC 57428
UNII-73A01W88SP
BIDD:ER0147
SCHEMBL712443
DTXSID1022471
Estra-1,5(10)-trien-3-ol
3-Hydroxyestra-1,5(10)-triene
NSC57428
estra-1,3,5(10)-triene-3-ol
BDBM50410523
(8S,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
Q27132230