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Guanosine

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Identification
Molecular formula
C10H13N5O5
CAS number
118-00-3
IUPAC name
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
State
State

Guanosine is typically found as a solid at room temperature. It is usually in the form of crystalline powder.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
792.00
Boiling point (Kelvin)
1 065.15
General information
Molecular weight
283.24g/mol
Molar mass
283.2410g/mol
Density
2.0500g/cm3
Appearence

Guanosine is a white to off-white crystalline powder. It is typically odorless and has a somewhat bitter taste. Its physical appearance might also vary slightly if hydrated.

Comment on solubility

Solubility of 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

The solubility characteristics of the compound with the formula C10H13N5O5 are intriguing and critical for understanding its potential applications. This complex structure leads to several noteworthy solubility aspects:

  • Polar Nature: The presence of multiple hydroxyl groups (–OH) in its structure enhances the compound's polar characteristics, which generally contribute to increased solubility in water.

  • Hydrophilic Interactions: The hydroxymethyl group and the tetrahydrofuran ring can engage in strong hydrogen bonding with water molecules, suggesting that the compound is likely to be quite soluble in aqueous environments.

  • Solvent Variability: While the compound demonstrates good solubility in polar solvents like water, its solubility may vary in non-polar solvents due to its structured nature. In fact, "as the polarity of the solvent decreases, solubility often diminishes."

  • Temperature Effects: The solubility may also be temperature-dependent. Generally, increased temperature tends to enhance solubility for most compounds, allowing for a broader understanding of how this compound performs under different conditions.

In summary, the solubility of 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one is anticipated to be favorable in polar solvents, primarily due to its polar functional groups and ability to engage in hydrogen bonding. This makes it a compound of interest in various biochemical applications and research avenues.

Interesting facts

Interesting Facts about 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

This compound is an intriguing member of the purine family, which plays a critical role in biochemistry, particularly in the structure of nucleic acids. Here are some remarkable insights about it:

  • Structure and Function: As a purine derivative, this compound is structurally related to nucleotides, the building blocks of DNA and RNA. Its unique sugar moiety contributes to its biological significance.
  • Biological Relevance: Compounds like this one are often involved in various biological processes, including energy transfer and cell signaling. They play a crucial role in the regulation of biochemical pathways.
  • Potential Applications: Researchers are exploring its potential as a pharmaceutical agent. Its ability to interact with specific biological targets positions it for roles in therapeutics, particularly in treating metabolic disorders.
  • Chirality and Stereochemistry: The compound's stereochemical configuration (as indicated by the (2R,3R,4S,5R) designation) suggests that it may exhibit unique interactions with enzymatic pathways due to its three-dimensional orientation.
  • Natural Occurrence: Many purine derivatives are naturally occurring, found in living organisms, and contribute to vital cellular processes.

It's captivating to consider how such small molecules can have such profound impacts on life. As one delves deeper into its chemistry, the twining stories of structure, function, and applications emerge, making it a riveting subject for further study.