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Cariprazine

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Identification
Molecular formula
C21H32F3N3
CAS number
839712-12-8
IUPAC name
9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole
State
State

Cariprazine is typically found in a solid state at room temperature, due to its application in medicinal formulations as a stable solid compound.

Melting point (Celsius)
169.50
Melting point (Kelvin)
442.65
Boiling point (Celsius)
530.50
Boiling point (Kelvin)
803.65
General information
Molecular weight
426.54g/mol
Molar mass
426.5400g/mol
Density
1.2300g/cm3
Appearence

Cariprazine is a white to off-white powder with no significant odor. It is typically used in the form of solid oral capsules in pharmaceuticals.

Comment on solubility

Solubility of 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole

The solubility of 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole can be quite complex due to its unique structure. Factors influencing its solubility include:

  • Polarity: With the presence of a trifluoromethyl group and a piperazine moiety, the compound exhibits both polar and non-polar characteristics.
  • Hydrogen Bonding: The piperazine ring can participate in hydrogen bonding, potentially enhancing solubility in polar solvents.
  • Size and Shape: The bulky carbazole structure may hinder solubility in certain solvents due to steric factors.

In general, this compound may be expected to have better solubility in:

  • Polar solvents like dimethyl sulfoxide (DMSO) and ethanol due to polar interactions.
  • Organic solvents such as methanol and acetonitrile, where its structure can align with solvent molecules.

However, *lower solubility* may be observed in:

  • Non-polar solvents like hexane and benzene due to incompatibility with the polar sections.

Ultimately, the precise solubility will be influenced by specific environmental conditions and the presence of other solutes. Therefore, experimental data is crucial for verifying solubility in various solvents.

Interesting facts

Exploring 9-[3-(4-Methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole

This fascinating chemical compound falls within the category of tetrahydrocarbazole derivatives, which are known for their significant biological activity. Here are some intriguing aspects of this compound:

  • Pharmaceutical Potential: The unique structure of this compound makes it a candidate for research in drug development, particularly in the field of neuropharmacology.
  • Structural Features: The presence of both trifluoromethyl and piperazine moieties enhances the compound's ability to interact with biological targets, possibly improving its pharmacokinetic properties.
  • Research Applications: Compounds of this class are often studied for their effects on the central nervous system, including neuromodulation, making this compound a topic of interest for those researching antidepressants or anxiolytics.
  • Fluorine Chemistry: The incorporation of trifluoromethyl groups is known to significantly alter the lipophilicity of compounds, which is crucial for drug-like properties and bioavailability.
  • Analog Compounds: Many analogs of tetrahydrocarbazole have been synthesized, showcasing a variety of substitutions that can lead to compounds with differing pharmacological effects.

As researchers continue to investigate compounds like 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole, they uncover a greater understanding of how small changes in molecular structure can lead to significant differences in biological activity. This highlights the beauty and complexity of medicinal chemistry in the quest for new therapeutic agents.