Skip to main content

Citalopram dihydrochloride

ADVERTISEMENT
Identification
Molecular formula
C20H23F3N2 · 2HCl
CAS number
59729-32-7
IUPAC name
9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole;dihydrochloride
State
State

At room temperature, citalopram dihydrochloride is typically in a solid state.

Melting point (Celsius)
180.50
Melting point (Kelvin)
453.65
Boiling point (Celsius)
380.70
Boiling point (Kelvin)
653.85
General information
Molecular weight
414.40g/mol
Molar mass
414.4010g/mol
Density
1.2206g/cm3
Appearence

Citalopram dihydrochloride is generally found as a white to off-white crystalline powder.

Comment on solubility

Solubility of 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole; dihydrochloride

The solubility of 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole; dihydrochloride is significant when considering its application in various biochemical contexts. This compound, possessing a complex organic structure, is often examined for its solubility in different solvents. Here are some key points regarding its solubility:

  • Polar Solvents: The presence of hydrochloride indicates a tendency for high solubility in polar solvents such as water, enhancing its bioavailability and potential therapeutic use.
  • Organic Solvents: It may exhibit reasonable solubility in organic solvents, although this can vary based on the solvent’s polarity and the compound's hydrophobic regions.
  • pH Dependence: The solubility can also be influenced by the pH of the solution, with variations observed in acidic and basic environments.

Overall, the solubility characteristics of this compound are essential for its effective use in pharmaceutical formulations and research applications. Understanding these solubility properties helps in predicting its behavior in biological systems and facilitates the optimization of drug delivery methods.

Interesting facts

Interesting Facts About 9-[3-(4-Methylpiperazin-1-yl)propyl]-5-(Trifluoromethyl)-1,2,3,4-tetrahydrocarbazole; Dihydrochloride

This fascinating compound, a member of the tetrahydrocarbazole family, has garnered significant interest in medicinal chemistry due to its potential therapeutic applications. Here are some noteworthy facts:

  • Pharmacological Potential: Compounds like this one are often investigated for their effects on the central nervous system. They may exhibit properties similar to those of antipsychotic or anxiolytic medications.
  • Structural Diversity: The presence of a 4-methylpiperazine moiety contributes to the compound's dynamic structure, potentially enhancing its binding affinity at various receptor sites.
  • Trifluoromethyl Group: The trifluoromethyl group in this structure is known for its ability to increase lipophilicity, which can enhance the compound's permeability across biological membranes, improving its efficacy.
  • Synthesis Challenges: Synthesizing such compounds often involves multi-step processes that require careful control of reaction conditions, showcasing the complexity of organic chemistry.
  • Research Horizons: Ongoing research in the field highlights the compound's promise in treating conditions such as depression and anxiety which have become increasingly important in modern medicine.

In summary, 9-[3-(4-methylpiperazin-1-yl)propyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazole; dihydrochloride represents a remarkable intersection of organic synthesis and pharmacology, reflecting the endless possibilities that await in the realm of drug discovery.

Synonyms
29465-21-2
Carbazole, 1,2,3,4-tetrahydro-9-(3-(4-methyl-1-piperazinyl)propyl)-5(or 7)-(trifluoromethyl)-,dihydrochloride
DTXSID10183671
RefChem:333249
DTXCID50106162