Carbamazepine | Solubility of Things

Identification

Molecular formula

C₁₅H₁₄N₂O

CAS number

298-46-4

IUPAC name

9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one

State

Carbamazepine is in a solid state at room temperature. It is typically used in tablet or capsule form as a medication, reflecting its stability and solid-state properties.

Melting point (Celsius)

189.00

Melting point (Kelvin)

462.15

Boiling point (Celsius)

665.15

Boiling point (Kelvin)

938.30

General information

Molecular weight

236.28g/mol

Molar mass

236.2780g/mol

Density

1.2300g/cm³

Appearence

Carbamazepine is a white to off-white crystalline powder. It is tasteless and odorless, making it relatively easy to handle in pharmaceutical preparations.

Comment on solubility

Solubility of 9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one

The solubility of 9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one can be rather complex due to its molecular structure. This compound exhibits certain characteristics that influence its solubility in various solvents:

Polar Solvents: It generally shows better solubility in polar solvents due to the presence of the dimethylamino group, which can interact favorably with polar molecules.
Non-Polar Solvents: Solubility in non-polar solvents might be limited because the bulkier aromatic structure can hinder interaction with less polar environments.
pH Dependency: The solubility can also vary with pH – most notably, the basic amine can ionize, leading to increased solubility in acidic conditions.
Temperature Effects: An increase in temperature may enhance solubility, allowing for more effective dissolution in suitable solvents.

Overall, it is crucial to consider the specific solvent environment, temperature, and pH when determining the solubility of this compound. Experimentation and empirical data play a significant role in understanding its behavior in different chemical contexts.

Interesting facts

Interesting Facts about 9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one

The compound 9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one belongs to the class of carbazole derivatives, which are known for their fascinating chemical properties and biological activities. Here are some intriguing points about this compound:

Structure and Flexibility: The unique structure of this compound includes a carbazole ring that offers a planar configuration, enhancing its ability to interact with various biological targets.
Pharmacological Significance: Many carbazole derivatives exhibit potential therapeutic properties, including anti-inflammatory, anti-cancer, and antioxidant activities. The addition of a dimethylamino group can modify the pharmacokinetics and improve the efficacy of such compounds.
Research Potential: Due to its complex structure, this compound serves as a scaffold in medicinal chemistry for the development of new drugs. Researchers are investigating how modifications can fine-tune its biological activity.
Applications in Organic Electronics: Compounds like this one may also play a role in organic electronic devices. Their electron-donating properties can be harnessed in organic photovoltaics and light-emitting diodes (OLEDs).
Inspiring Nature: The exploration of carbazole derivatives is often inspired by natural products found in plants. These natural compounds frequently display remarkable bioactivities, prompting further synthetic exploration.

As noted by many chemists, "The beauty of organic synthesis lies in the ability to transform simple building blocks into complex molecules." This compound embodies that idea, highlighting the interplay between structure and function in chemical research.

In conclusion, 9-[3-(dimethylamino)propyl]-3,4-dihydro-2H-carbazol-1-one showcases the vast potential of carbazole chemistry, merging the realms of medicinal chemistry with materials science in an inspiring journey of discovery.