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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
9-(4-isopropylpiperazin-1-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-one
State
State

At room temperature, Clozapine is typically in a solid state. It is stable under normal conditions and should be stored in a dry environment to prevent degradation.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
589.60
Boiling point (Kelvin)
862.80
General information
Molecular weight
327.83g/mol
Molar mass
326.8320g/mol
Density
1.2800g/cm3
Appearence

Clozapine appears as a pale yellow, crystalline powder. It is notable for its fine texture and can form clumps when exposed to moisture. In pure form, it is nearly odorless.

Comment on solubility

Solubility of 9-(4-isopropylpiperazin-1-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-one

The solubility of 9-(4-isopropylpiperazin-1-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-one is an intriguing aspect to consider for its potential applications. Understanding solubility can provide insight into how this compound may be utilized in various environments. Here are some key points regarding its solubility:

  • Polarity: The structure of this compound incorporates both polar and nonpolar functional groups, which can lead to variable solubility in solvents.
  • Solvent Compatibility: It may exhibit solubility in organic solvents such as ethanol or DMSO, while being less soluble in water due to its complex structure.
  • Temperature Dependence: As with many compounds, solubility can be temperature-dependent, potentially increasing in higher temperatures.
  • pH Influence: The solubility could also be influenced by the pH of the solution, especially if it interacts with acids or bases.

In summary, the solubility of this compound can be highly variable depending on various chemical environments. Therefore, conducting specific solubility tests in relevant solvents is crucial for understanding its behavior in practical applications.

Interesting facts

Exploring 9-(4-isopropylpiperazin-1-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-one

This intriguing compound, known for its complex structure, belongs to a class of organic compounds that often exhibit interesting biological activities. The versatility of its molecular architecture allows for various applications, particularly in the field of medicinal chemistry.

Structural Highlights

  • Tricyclic Framework: The compound contains a unique tricyclo structure that contributes to its stability and reactivity.
  • Piperazine Moiety: The presence of a piperazine ring enhances its pharmacological properties, making it a candidate for further studies in therapeutic settings.
  • Polyunsaturated System: The heptaenal chain suggests potential interactions with various biological targets, indicating that it could serve as a base for designing new drugs.

Biological Activity

Compounds similar to this one have demonstrated a range of biological activities, including:

  • Antidepressant properties: Many piperazine derivatives are known for their efficacy in treating mood disorders.
  • Antipsychotic effects: The structural characteristics can allow for interaction with neurotransmitter pathways.
  • Anti-cancer potential: The unique arrangement of atoms may provide a foundation for innovative cancer therapies.

Chemistry in Action

As a scientist or a chemistry student, one might find it interesting to explore the various synthetic pathways to achieve this compound. Understanding how to manipulate the reaction conditions, such as:

  • Choosing the right catalysts
  • Optimizing solvent systems
  • Controlling temperature and pressure

could lead to novel variants with improved properties.

In summary, 9-(4-isopropylpiperazin-1-yl)tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-one stands as a testament to the complexity and beauty of organic chemistry, presenting opportunities for exploration in both research and practical applications. Its varying biological activities open doors for innovative solutions in health sciences.

Synonyms
RMI 60881
BRN 0897031
5H-DIBENZO(a,d)CYCLOHEPTEN-5-ONE, 10-(4-ISOPROPYL-1-PIPERAZINYL)-
16270-56-7
10-(4-Isopropyl-1-piperazinyl)-5H-dibenzo(a,d)cyclohepten-5-one
DTXSID60167441
5H-Dibenzo(a,d)cyclohepten-5-one, 10-(4-(1-methylethyl)-1-piperazinyl)-
DTXCID5089932