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Tacrine

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Identification
Molecular formula
C13H14CIN3
CAS number
321-64-2
IUPAC name
9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine
State
State

At room temperature, Tacrine is typically a solid.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.20
Boiling point (Celsius)
418.30
Boiling point (Kelvin)
691.50
General information
Molecular weight
287.39g/mol
Molar mass
287.3850g/mol
Density
1.2830g/cm3
Appearence

Tacrine typically appears as a white to off-white powder. It is known to be crystalline in nature.

Comment on solubility

Solubility Insights on 9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine

The solubility of 9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine can be complex, influenced by several factors including its chemical structure and the polarity of the solvent. Here are some key considerations:

  • Polarity: This compound features both hydrophobic and hydrophilic portions, making it potentially soluble in a variety of solvents.
  • Solvent Interaction: It is likely to exhibit good solubility in polar solvents like water and alcohols due to the presence of the piperazine ring, which can engage in hydrogen bonding.
  • pH Dependence: Solubility may vary with pH, as ionization can occur with changes in acidity or basicity, significantly impacting its ability to dissolve.
  • Temperature Effects: As with many compounds, increased temperature may enhance solubility, allowing for better interactions with the solvent.

As a general trend, it is often stated that "like dissolves like," meaning the solubility will be greater in solvents with similar polarity to that of the compound.

In summary, while specific solubility data for 9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine might not be extensively documented, understanding its structural nuances provides a clearer picture of its potential solubility characteristics.

Interesting facts

Interesting Facts about 9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine

9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine is a fascinating compound with intriguing properties and potential applications. Here are some noteworthy points about this compound:

  • Structural Complexity: The structure of this compound features a unique acridine skeleton, which is a nitrogen-containing aromatic compound. This structural complexity is key to its activities.
  • Biological Relevance: Compounds like this one are often studied for their potential biological activities, including effects on the central nervous system. Some derivatives have been investigated for their role in neuroprotective strategies and as potential treatments for neurodegenerative diseases.
  • Drug Design: Due to its structural attributes, this compound serves as a promising scaffold in medicinal chemistry, particularly in the design of novel therapeutics targeted towards diseases like Alzheimer's.
  • Functional Groups: The presence of the 4-methylpiperazine moiety is significant. This group is known for enhancing the bioavailability and solubility of compounds, making them more effective in biological systems.
  • Research Potential: Ongoing research into this compound could unveil more about its pharmacological properties, including its potential to affect cholinergic and dopaminergic pathways, which are crucial for cognitive function.

As a compound that bridges both organic chemistry and pharmacology, 9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine represents a prime example of how structural novelty can lead to significant advancements in medical science.

Synonyms
7032-38-4
ACRIDINE, 1,2,3,4-TETRAHYDRO-9-(4-METHYL-1-PIPERAZINYL)-
NSC 107312
BRN 0813117
2XPD445AJ7
NSC-107312
UNII-2XPD445AJ7
4-(4-Methyl-1-piperazinyl)-2,3-tetramethylenequinoline
Acridine, 9-(4-methyl-1-piperazinyl)-1,2,3,4-tetrahydro-
Piperazine, 1-(1,2,3,4-tetrahydro-9-acridinyl)-4-methyl-
DTXSID40220604
5-23-03-00082 (Beilstein Handbook Reference)
1,2,3,4-Tetrahydro-9-(4-methyl-1-piperazinyl)acridine
DTXCID30143095
9-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroacridine
NSC107312
DS-006391
Acridine,2,3,4-tetrahydro-9-(4-methyl-1-piperazinyl)-