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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one
State
State

At room temperature, tenofovir is typically in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
1.4951g/cm3
Appearence

Tenofovir typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility Characteristics

The solubility of the compound 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one can be a fascinating topic due to its unique structural components. This compound contains multiple functional groups which significantly influence its solubility behavior.

Factors Influencing Solubility

  • Hydroxyl Groups: The presence of hydroxyl (-OH) groups typically enhances solubility in polar solvents, such as water. This is due to the ability to form hydrogen bonds.
  • Purine Structure: The purine base also adds to the polar characteristics of the molecule, potentially improving solubility in aqueous environments.
  • Phosphinic Group: The phosphinic moiety may contribute to the compound's interaction with water, possibly aiding solubility through coordination effects.

However, it is crucial to note that the overall solubility is also dependent on other factors such as temperature, pH, and the presence of other ions or solvents in the solution.

General Observations

In conclusion, while the compound's complex structure suggests potential for good solubility, empirical testing is necessary to determine the precise solubility characteristics. As a rule of thumb, compounds exhibiting a balance of polar and non-polar characteristics will show limited solubility in pure solvents but may dissolve effectively in mixed solvent systems. Therefore, further studies are warranted to fully elucidate its solubility profile.

Interesting facts

Interesting Facts about 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one

This fascinating compound belongs to a unique class of biologically active molecules that showcase the wonders of medicinal chemistry. Its complex structure, which features both purine and phosphorus-containing moieties, makes it a subject of great interest in various areas of biological research.

Biological Significance

  • Nucleotide Analogs: The purine component indicates that this compound could serve as an analog to natural nucleotides, potentially influencing DNA and RNA synthesis.
  • Enzyme Inhibition: The dioxaphosphinin segment suggests that it may interact with enzymatic activity, providing a potential pathway for drug development against various diseases.
  • Pharmacological Implications: Its multifaceted structure lends it potential applications in treating cancer and viral infections by disrupting fundamental biological processes.

Structural Complexity

The intricate arrangement of atoms in this compound is emblematic of the challenges faced in modern chemistry:

  • Chirality: The presence of asymmetric carbon centers means that the compound can exist in multiple stereoisomeric forms, which may exhibit different biological activities.
  • Functional Groups: The hydroxyl groups embedded in its structure are often crucial for the compound's reactivity and interaction with biological targets.
  • Tetrahydrofuran Rings: These ring structures contribute significantly to the compound’s stability and solubility characteristics.

Research Opportunities

Future studies on this compound may focus on:

  • Synthetic Pathways: Exploring new methods of synthesis could lead to even more effective derivatives.
  • Biological Testing: Understanding its mechanism of action could pave the way for novel therapeutic strategies.
  • Target Identification: Investigating its specific biological targets will be essential for harnessing its potential effectively.

In summary, this compound is more than just a chemical entity; it represents the intersection of chemistry and biology, presenting numerous opportunities for research and application in the pharmacological realm.