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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purin-6-one
State
State

At room temperature, Tenofovir is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.15
Boiling point (Celsius)
574.50
Boiling point (Kelvin)
847.70
General information
Molecular weight
287.22g/mol
Molar mass
287.2150g/mol
Density
1.5000g/cm3
Appearence

Tenofovir typically appears as a white to off-white crystalline powder. It is known for its low aqueous solubility and high stability.

Comment on solubility

Solubility of 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purin-6-one

The solubility of the compound 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purin-6-one is intriguing and may vary significantly depending on various factors.

Factors Affecting Solubility:

  • Polarity: The presence of multiple hydroxyl groups and dioxaphosphinin structures can enhance polarity, potentially increasing solubility in polar solvents.
  • Temperature: Higher temperatures generally increase solubility as solute molecules gain kinetic energy.
  • pH Levels: The solubility of compounds with functional groups can be significantly influenced by the pH of the solvent, with certain groups being more soluble under acidic or basic conditions.

Additionally, it is essential to note that while many compounds may dissolve well in solvents such as water or ethanol, others might exhibit poor solubility in conventional solvents, thus necessitating the use of co-solvents or surfactants to achieve desired solubility levels.

In summary, the solubility of this compound is not strictly defined and warrants consideration of both chemical structure and environmental conditions to predict its behavior in various solvents effectively.

Interesting facts

Interesting Facts about 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purin-6-one

This compound is a fascinating example of complex organic chemistry, particularly within the field of pharmacology and biochemistry. Here are some interesting aspects to consider:

  • Structure and Complexity: The name itself reveals a highly intricate structure, representative of a class of molecules that combines elements of both purines and phosphonates. The presence of multiple functional groups emphasizes its potential for a variety of chemical reactions!
  • Biological Relevance: Compounds of this type often exhibit significant biological activity. They might play roles in cellular pathways, particularly in energy transfer and signal transduction, owing to their purine structure.
  • Pharmacological Potential: Researchers have been intrigued by the therapeutic potentials of such formulations. Similar compounds have been investigated for their roles in treating diseases such as cancer or viral infections.
  • Chirality: The compound features several chiral centers, which can have a profound impact on its biological activity and pharmacokinetics. This aspect makes stereochemistry a vital consideration in any related research.
  • Environmental Applications: Emerging studies suggest that analogs of this compound could have applications in environmental chemistry, aiding in the development of biodegradable pesticides or herbicides.

With ongoing research, compounds like this are constantly being revisited, unveiling new avenues for study and potential application. Engaging with these complex structures not only enriches our understanding of chemical science but also opens the door to innovations in medicine and beyond!