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Tacrine

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Identification
Molecular formula
C13H14ClN
CAS number
321-64-2
IUPAC name
9-chloro-1,2,3,4-tetrahydroacridine
State
State

At room temperature, Tacrine is a solid.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
409.72
Boiling point (Kelvin)
682.87
General information
Molecular weight
213.69g/mol
Molar mass
213.6940g/mol
Density
1.3000g/cm3
Appearence

Tacrine is typically seen as an off-white to slightly yellow solid. It may appear as crystalline or powder form depending on its preparation and storage conditions.

Comment on solubility

Solubility of 9-chloro-1,2,3,4-tetrahydroacridine

9-chloro-1,2,3,4-tetrahydroacridine, with the chemical formula C13H12ClN, exhibits some interesting solubility characteristics. Understanding its solubility is crucial for its application in various fields, including pharmaceuticals and chemical research. Here’s what you should know:

  • Solvent Compatibility: This compound is generally soluble in organic solvents, such as ethanol and dichloromethane, due to its aromatic structure, which favors interaction with non-polar media.
  • Water Solubility: 9-chloro-1,2,3,4-tetrahydroacridine has limited solubility in water. This is primarily because of the presence of the hydrophobic acridine ring, which impedes extensive interactions with polar water molecules.
  • pH Dependence: Its basic nitrogen atom may also influence solubility in different pH environments, potentially improving solubility in acidic conditions.

In summary, while the solubility of 9-chloro-1,2,3,4-tetrahydroacridine in water is limited, its favorable solubility in various organic solvents makes it suitable for a range of applications. Remember, "the choice of solvent can significantly affect the behavior of the compound," so select wisely based on your specific needs!

Interesting facts

Interesting Facts about 9-Chloro-1,2,3,4-Tetrahydroacridine

The compound 9-chloro-1,2,3,4-tetrahydroacridine is gaining attention in the field of pharmaceuticals and organic chemistry due to its intriguing properties and potential applications. Here are some fascinating facts about this fascinating compound:

  • Structure & Reactivity: The unique structure of 9-chloro-1,2,3,4-tetrahydroacridine, which includes a bicyclic framework, contributes to its reactivity and allows for interesting chemical transformations. The presence of the chlorine atom can also impact its chemical behavior and interactions with other molecules.
  • Medical Implications: Research has suggested that compounds related to tetrahydroacridines have potential pharmacological effects, including neuroprotective properties. This makes 9-chloro-1,2,3,4-tetrahydroacridine a subject of interest for studies related to neurodegenerative diseases.
  • Natural Product Inspiration: This compound is inspired by several natural alkaloids, which often exhibit interesting biological activities. Studying synthetic analogs like 9-chloro-1,2,3,4-tetrahydroacridine can lead to the development of new therapeutic agents.
  • Synthetic Methodology: Synthesis of 9-chloro-1,2,3,4-tetrahydroacridine can involve various methods, including multi-step reactions that highlight the versatility of synthetic organic chemistry. This allows chemists to explore different pathways and optimize yields.
  • Research Opportunities: As a lesser-known compound, 9-chloro-1,2,3,4-tetrahydroacridine presents numerous opportunities for academic research. Its unique properties may lead to further discoveries in medicinal chemistry and material sciences.

In summary, 9-chloro-1,2,3,4-tetrahydroacridine stands at the intersection of organic chemistry and pharmacology, making it a compound worth exploring for its potential applications and contributions to scientific knowledge.

Synonyms
9-Chloro-1,2,3,4-tetrahydroacridine
5396-30-5
1,2,3,4-Tetrahydro-9-chloroacridine
ACRIDINE, 1,2,3,4-TETRAHYDRO-9-CHLORO-
NSC 1235
BRN 0147607
DTXSID40202248
5-20-07-00600 (Beilstein Handbook Reference)
DTXCID40124739
654-150-2
9-chloro-5,6,7,8-tetrahydroacridine
59YJK4BWG6
Acridine, 9-chloro-1,2,3,4-tetrahydro-
NSC-1235
9-Chloro-1,2,3,4-tetrahydro-acridine
NSC1235
MFCD00065216
9-chlorotetrahydroacridine
UNII-59YJK4BWG6
SCHEMBL1337681
CHEMBL3221003
IYPJWKLHPNECFJ-UHFFFAOYSA-N
KUC110914N
ALBB-006313
STK501220
9chloro-1,2,3,4-tetrahydroacridine
AKOS000265450
KSC-280-035
AC-17534
LS-02224
9-CHLORO-1,3,4-TETRAHYDROACRIDINE
DB-052441
CS-0069003